Dunja Maroeska W.M. Te Loo's research while affiliated with Radboud University Medical Centre (Radboudumc) and other places

Publications (9)

Article
6-mercaptopurine (6-MP) is the mainstay in pediatric acute lymphoblastic leukemia (ALL) maintenance treatment. Variants in genes coding for thiopurine S-methyl transferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are known to influence 6-MP metabolism. We determined TPMT and ITPA genotype and enzyme activity and the mean 6-MP doses du...
Article
In osteosarcoma, large variation is observed in the efficacy and toxicity of chemotherapeutic drugs among similarly treated patients. Treatment optimization using predictive factors or algorithms is of importance, because there has been a lack of improvement of treatment outcome and survival for decades. The outcome of cancer treatment is influence...
Article
Objective: Irreversible hearing loss is a frequent side effect of the chemotherapeutic agent cisplatin and shows considerable interpatient variability. The variant rs1872328 in the ACYP2 gene was recently identified as a risk factor for the development of cisplatin-induced ototoxicity in children with brain tumors. We aimed to replicate this findi...

Citations

... S-adenosylmethionine (SAM) is an active methyl donor for TPMT and COMT mediate most of these reactions as the main methyltransferases. TPMTs catalyze the S-methylation of aromatic and heterocyclic sulfur-containing compounds, such as 6-mercaptopurine (6 MP), azathioprine and 6-thioguanine, used in clinical disease treatment (Kouwenberg et al., 2020). COMTs are the phase II enzymes responsible for the transfer of a methyl group from S-adenosylmethionine to its substrate. ...
... 8 In OS, increased expression of APE1 and MDR1 was shown to be associated with poorer OS prognosis. 9,10 In addition, a risk signature of three survival-associated genes, MYC, CPE, and LY86, could discriminate between low-and high-mortality risk in OS patients. 11 Unfortunately, data on prognostic biomarkers for OS remain unsatisfactory for any clinical use. ...
... Particular genotype distributions were found for 9 SNPs. Five SNPs that had been reported in association with CDDP-related ototoxicity, ACYP2 rs1872328 [7], ABCC2 rs17222723 [8], TPMT rs12201199, rs1142345, and rs1800460 [9][10][11], were present only in the wild-type status in all cell lines. Two SNPs, ABCC2 rs717620 and GSTP1 rs1695, were found as homozygous wild-type or heterozygous but not as homozygous variant. ...