Doron Todder's research while affiliated with Ben-Gurion University of the Negev and other places
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Publications (43)
In the wild, animals face a highly variable world full of predators. Most predator attacks are unsuccessful, and the prey survives. According to the conventional perspective, the fear responses elicited by predators are acute and transient in nature. However, the long-term, non-lethal effects of predator exposure on prey behavioral stress sequelae,...
Sleep figures in numerous ancient texts, for example, Epic of Gilgamesh, and has been a focus for countless mystical and philosophical texts. Even in the present century, sleep remains one of the most complex behaviors whose function still remains to be further explored. Current hypotheses suggest that among other functions, sleep contributes to me...
MDMA (3,4-methylenedioxymethamphetamine), a synthetic ring-substituted amphetamine, combined with psychotherapy has demonstrated efficacy for the treatment of chronic posttraumatic stress disorder (PTSD) patients. This controlled prospective study aimed to assess the bio-behavioral underpinnings of MDMA in a translational model of PTSD. Rats expose...
The present study investigates whether predator scent-stress (PSS) shifts the microglia from a quiescent to a chronically activated state and whether morphological alterations in microglial activation differ between individuals displaying resilient vs. vulnerable phenotypes. In addition, we examined the role that GC receptors play during PSS exposu...
Exposure to high ambient temperature is a stressor that influences both biological and behavioral functions and has been previously shown to have an extensive impact on brain structure and function. Physiological, cellular and behavioral responses to heat-stress (HS) (40–41 °C, 2 h) were evaluated in adult male Sprague-Dawley rats. The effect of HS...
Endocannabinoids play a role in adaptation to stress and regulate the release of glucocorticoids in stressed and unstressed conditions. We recently found that basal corticosterone pulsatility may significantly impact the vulnerability for developing post-traumatic-stress-disorder (PTSD), suggesting that the endocannabinoid system may contribute to...
Previously, we found that basal corticosterone pulsatility significantly impacts the vulnerability for developing post-traumatic stress disorder (PTSD). Rats that exhibited PTSD-phenotype were characterized by blunted basal corticosterone pulsatility amplitude and a blunted corticosterone response to a stressor. This study sought to identify the me...
Background and Objectives: Mild cognitive impairment (MCI) is often a precursor of dementia, and in particular of Alzheimer's Disease (AD) which is the most common cause of dementia. Individuals with amnestic MCI are several-fold more likely to develop AD than the general population. Therefore, MCI comprises a well-detectable, early stage time-poin...
These authors contributed equally to this work. All other authors are listed in reverse alphabetical order. Neurofeedback has begun to attract the attention and scrutiny of the scientific and medical mainstream. Here, neurofeedback researchers present a consensus-derived checklist that aims to improve the reporting and experimental design standards...
Given the interest in improving executive functions, the present study examines a promising combination of two training techniques: neurofeedback training (NFT) and working memory training (WMT). NFT targeted increasing the amplitude of individual’s upper Alpha frequency band at the parietal midline scalp location (Pz), and WMT consisted of an esta...
Neurofeedback has begun to attract the attention and scrutiny of the scientific and medical mainstream. Here, neurofeedback researchers present a consensus-derived checklist that aims to improve the reporting and experimental design standards in the field.
Background:
Negative symptoms of schizophrenia show limited response to both typical and atypical antipsychotics. Repetitive transcranial magnetic stimulation applied over the prefrontal cortex (PFC) has been proposed as an adjuvant to pharmacological treatment of negative symptoms in schizophrenia, but whether the improvements obtained are specif...
Mild cognitive impairment (MCI) is a syndrome characterized by a decrease in cognitive abilities, while daily function is maintained. This condition, which is associated with an increased risk for the development of Alzheimer’s disease, has no known definitive treatment at present. In this open-label pilot study we explored the possible benefits of...
This checklist is intended to encourage robust experimental design and clear reporting for clinical and cognitive-behavioural neurofeedback experiments.
This checklist is intended to encourage robust experimental design and clear reporting for clinical and cognitive-behavioural neurofeedback experiments. Available at https://psyarxiv.com/nyx84
Objective:
Dissociation refers to a disintegration between psychological elements; common manifestations are embodied in "absorption and imaginative involvement", a propensity for being immersed in a stimulus while oblivious to the environment, and acting without awareness. Trait dissociation was hypothesized to relate to lower EEG signal connecti...
Objective:
Studies have shown that transcranial direct current stimulation (tDCS) has immediate effects on brain activity. The aim of this study was to investigate the potential use of tDCS to regulate obsession-induced anxiety immediately after symptom provocation in patients with refractory obsessive-compulsive disorder (OCD).
Methods:
Twelve...
Resting-state electroencephalogram (rsEEG) has been found to be associated with psychopathology, intelligence, problem solving, academic performance and is sometimes used as a supportive physiological indicator of enhancement in cognitive training interventions (e.g. neurofeedback, working memory training). In the current study, we measured rsEEG s...
We report reduced repetitive behaviors similar to obsessive compulsive disorder and improved emotional recognition and cognitive abilities in two young patients diagnosed with high-functioning Autism as a result of deep transcranial magnetic stimulation (dTMS). The patients received daily high-frequency (5 Hz) dTMS with HAUT-coil over the medial pr...
Task control is an executive control mechanism that facilitates goal-directed task selection by suppressing irrelevant automatic “stimulus-driven” behaviors. In the current study, we test the hypothesis that less efficient task control in individuals diagnosed with obsessive-compulsive disorder (OCD) is associated with OCD symptoms, and specificall...
Optimizing performance of aviators while minimizing risks arising from the exposure to extreme environment, both external and internal, is one of the principles guiding the Israeli Air Force. Young cadets in particular are considered an “at risk” population due to the fact that they have no experience in flight in the first stages of training and a...
Introduction:
Noninvasive brain stimulation is a growing field of treatment for many neuropsychiatric problems. In this review, several of the more common brain stimulation devices are presented. Specifically, we will review Transcranial Magnetic Stimulation (TMS), Transcranial Direct Current Stimulation (tDCS), Alternating Current Stimulation (AC...
Background:
The most common cause of dementia is Alzheimer's disease. The major manifestation of the disease is the cognitive impairment which appears at the onset of the disease. In addition to the cognitive impairment there are behavioral dysfunctions such as apathy, anxiety, depression and sleep disturbances. The treatment for the manifestation...
Introduction:
The Beer Sheva Mental Health Center is the second largest mental health hospital in Israel and provides acute and chronic in-patient services for the entire population of the Southern District of Israel, from Ashdod to Eilat (about 1.2 million people) from adolescence to the elderly. The outpatient services include a variety of regio...
Purpose: Neurofeedback (NFB) training has demonstrated significant potential in achieving symptoms reduction in children with Autism Spectrum Disorder (ASD). However, children with low-functioning ASD are often uncooperative with the treatment. To evaluate whether NFB can eventually be administrated during sleep, a safety and feasibility pilot stud...
Background:
Patients diagnosed with Alzheimer disease (AD) show severe cognitive deficits. Decline in memory, language, and executive function have repeatedly been reported. Although AD affects 60% to 80% of demented elderly patients, there is currently no cure and limited treatment alternatives.
Objectives:
The aim of the study was to evaluate...
Electroencephalography source localization neurofeedback, i.e Standardized Low-Resolution Tomography (sLORETA) neurofeedback are non-invasive method for altering region specific brain activity. This is an improvement over traditional neurofeedback which were based on recordings from a single scalp-electrode. We proposed three criteria clusters as a...
The benefits of clinical neurofeedback training are well known, however, its adverse side-effects are less studied. This research focuses on the transient adverse side effects of neurofeedback training via a double-blind, sham/controlled methodology. Thirty healthy undergraduate students volunteers were randomly divided into three treatment groups:...
The relationships between memory processes and oscillatory electroencephalography (EEG) are well established. Neurofeedback training (NFT) may cause participants to better regulate their brain EEG oscillations. The present study is a double-blind sham-controlled design investigating the effect of NFT on memory. NFT included up-training upper alpha...
Unlabelled:
"Language is a form and not a substance" - Ferdinand de Saussure Objective: Analyses of speech processes in schizophrenia are invariably focused on words as vocal signals. The results of such analyses are, however, strongly related to content, and may be language- and culture-dependent. Little attention has been paid to a pure measure...
The main objective of this study was to evaluate the role of the concentration of solid air-suspended particles (SSP) in the incidence of mental disorders. The study is based on 1,871 cases, registered in the Beer-Sheva Mental Health Center (BS-MHC) at Ben-Gurion University (Israel) during a 16-month period from 2001 to 2002; 1,445 persons were hos...
The incidence of suicide attempts [Deliberate Self Harm (DSH); ICD-10: X60-X84] and psychotic attacks (PsA; ICD-10, F20-F29) in association with atmospheric states, typical for areas close to big deserts, was analyzed. A retrospective study is based on the 4,325 cases of DSH and PsA registered in the Mental Health Center (MHC) of Ben-Gurion Univers...
The aim of the study was to investigate the influence of escitalopram on peripheral body temperature (PBT) in panic disorder. In a 4 week case-control study (N = 12 female patients; N = 12 matched healthy controls), the daytime PBT declined compared to night time PBT in patients. The prospective relationship between PBT and panic disorder shows a d...
A PUBMED search for 'mathematical models in medicine' shows more than 15,000 articles covering almost every field of medicine. We designed a course with the goal of developing the students' skills in computerized data analysis and mathematical modelling, as well as enhancing their ability to read and interpret mathematical data analysis. The study...
Psychomotor retardation (PR) is among the most important features of depression. This study investigates the development of day- and night-time as well as intensity and quantity of circadian motor activity during a 4-week course of treatment among 27 patients with depression compared to 27 healthy controls. A diagnosis of major depression was made...
In order to effectively reduce the risk of developing long-lasting mental disorders in the aftermath of traumatic stress exposure, interventions must be offered early on. Therefore, access to expert assistance can have significant effects on prognosis. Rapid eye movements are part of the Eye Movement Desensitization and Reprocessing procedure that...
In order to effectively reduce the risk of developing acute stress disorder (ASD) and/or posttraumatic stress disorder (PTSD) in the aftermath of traumatic stress exposure, interventions must be offered early on. Therefore, access to expert assistance can have significant effects on prognosis. Conditions which compromise accessibility and prevent d...
This report describes a patient suffering from panic disorder who developed repeated suicidal ideation specifically due to the treatment with Venlafaxine. A first suicide attempt years ago occurred while being treated with Venlafaxine. Subsequent treatment with SSRIs or other antidepressants involved no suicidal ideation. Re-commencement of Venlafa...
This research assesses the development of the night-activity rhythm and quality of sleep during course of treatment among patients with unipolar or bipolar depression and receiving antidepressant treatment plus quetiapine. Twenty-seven patients with major depressive episode were included into a 4-week follow-up study and compared with 27 healthy co...
The use of atypical antipsychotic agents is associated with the induction of both an indolent progression to insulin-resistant diabetes and an idiosyncratic beta-cell toxicity presenting as diabetic ketoacidosis, both of which are usually reversible or improved subsequent to cessation of treatment. The underlying mechanisms are unclear at present....
Citations
... One line of research (Kuriyama et al., 2010;Porcheret, Holmes, Goodwin, Foster, & Wulff, 2015) hypothesizes that sleep-related consolidation mechanisms strengthen implicit memory processes, thereby facilitating intrusion development after trauma. Consequently, sleep deprivation during the night after trauma is proposed as a prevention strategy (Cohen et al., 2023). Another line of research (e.g., Kleim et al., 2016;Sopp, Brueckner, Schäfer, Lass-Hennemann, & Michael, 2019;Zeng, Lau, Li, & Hu, 2021) suggests that -by selectively strengthening explicit rather than implicit trauma memories -sleep may reduce intrusion development. ...
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... However, even under mild training conditions, a small proportion of subjects might develop a maladaptive memory, allowing the adoption of cutoff behavioral criteria to segregate heterogeneous susceptible/resilient subpopulations (Cohen et al., 2003Daskalakis et al., 2013;Scott et al., 2022). Such strategies must be considered and could be adopted in protocols yielding either adaptive or maladaptive memories as an additional tool to evaluate biological mechanisms underlying vulnerability/resilience and associated outcomes (Brodnik et al., 2017;Dopfel et al., 2019;Tseilikman et al., 2020;Nahum et al., 2022;Blount et al., 2023). ...
... All behavioral tests were video-recorded using the ETHO-VISION program (Noldus), by an investigator blinded to the experimental protocol. Behaviors of specimens were assessed using OFT, EPM and ASR, as described previously [24][25][26]. Detailed protocols are described in Supplementary Information #3:1. ...
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... In response to the stress stimuli (e.g., heat, ischemia, heavy metals, and toxins), to repairing the damaged protein and prevent cell death protein shock proteins (HSPs) are overexpressed [46,47]. Tumor cells have a high heat tolerance, this action may ultimately cause PTT to be delayed or perhaps fail. ...
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... However, in participants belonging to racial/ ethnic minorities, 2-AG was significantly positively correlated with PTSD severity at the follow-up and AEA levels were significantly, negatively correlated with PTSD severity at hospitalization (deRoon-Cassini et al., 2022). In the overall sample, the findings from this study are similar to a recent animal study that found significantly higher 2-AG (but not AEA) concentrations in PTSD-phenotype rats 1 day but not 8-day poststress exposure, where endocannabinoid concentrations were lower (Danan et al., 2021), suggesting that extreme endocannabinoid responses to stress in the short term may be associated with later PTSD onset. ...
... The body of evidence implies that learning to control the activation of specific brain regions is related to improving cognitive functions and behavior (Sulzer et al., 2013;Acevedo et al., 2022). Some studies have reported the benefits of neurofeedback for attention deficit hyperactivity disorder (Lofthouse et al., 2012;Thibault et al., 2018), depressive disorder (Choi et al., 2011;Lee et al., 2019), posttraumatic stress disorder (Nicholson et al., 2020;Panisch and Hai, 2020), and MCI (Lavy et al., 2021;Acevedo et al., 2022; see review Trambaiolli et al., 2021). ...
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... It's important to note that the dysregulation of GC signaling in PTSD is complex and can vary among individuals. Further research is needed to elucidate the precise mechanisms involved in GC signaling dysregulation in PTSD and its implications for the development and maintenance of the disorder [14]. Alterations in glucocorticoid receptors (GR) have also been noted. ...
... The sample size is determined based on a heuristic justification (36) according to median recruits (n = 18) of fMRI neurofeedback (37). Moreover, given that this is a feasibility study with constraints on limited resources, a power calculation is not necessary according to the reporting and experimental design consensus in the NF field (38). ...
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... Finally, Kortteisto et al. (2010) uncovered that ATB, SN, and PBC were associated with the intentions of healthcare professionals to use clinical practice guidelines in the area of their specialization for decisions on patient care. As noted by Lyndon (2016), emotional exhaustion, cynical detachment, and physical fatigue impair the cognitive functions of nurses, threatening both the quality of healthcare and patient safety. O'Mahony (2011) also found that high emotional exhaustion and depersonalization are significantly related to the nature of the nurses' work environment. ...
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... Furthermore, we conducted 16 sessions of training, which might not have been a sufficient training period to examine changes in executive functions in healthy young adults. In a previous study, it has been demonstrated that studies with more than 20 sessions of training have resulted in significant changes [40,41], whereas those with fewer training sessions have not yielded significant results [42][43][44]. ...
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