Dongun Lee's research while affiliated with Gachon University and other places
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Publications (12)
Lysosomes are responsible for protein degradation and clearance in cellular recycling centers. It has been known that the lysosomal chloride level is enriched and involved in intrinsic lysosomal function. However, the mechanism by which chloride levels can be sensed and the chloride-mediated lysosomal function is unknown. In this study, we verified...
PyK2 is a member of the proline-rich tyrosine kinase and focal adhesion kinase families and is ubiquitously expressed. PyK2 is mainly activated by stimuli, such as activated Src kinases and intracellular acidic pH. The mechanism of PyK2 activation in cancer cells has been addressed extensively. The up-regulation of PyK2 through overexpression and e...
The ubiquitin–proteasome system (UPS) is the main proteolytic pathway by which damaged target proteins are degraded after ubiquitination and the recruit of ubiquitinated proteins, thus regulating diverse physiological functions and the maintenance in various tissues and cells. Ca2+ signaling is raised by oxidative or ER stress. Although the basic f...
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Estrogen therapy has used to prevent bone loss in postmenopausal women. Although therapeutically enhanced estrogen levels have been suggested, patients are exposed to greater risks of nephrolithiasis and cancer. It has been known that oxalate or bicarbonate transporter SLC26A6 is involved in oxalate homeostasis and its deletion results in kidney...
Metastatic features of breast cancer in the brain are considered a common pathology in female patients with late-stage breast cancer. Ca2+ signaling and the overexpression pattern of Ca2+ channels have been regarded as oncogenic markers of breast cancer. In other words, breast tumor development can be mediated by inhibiting Ca2+ channels. Although...
Applications of nanoparticles in various fields have been addressed. Nanomaterials serve as carriers for transporting conventional drugs or proteins through lysosomes to various cellular targets. The basic function of lysosomes is to trigger degradation of proteins and lipids. Understanding of lysosomal functions is essential for enhancing the effi...
The bicarbonate ion has a fundamental role in vital systems. Impaired bicarbonate transport leads to various diseases, including immune disorders, cystic fibrosis, tumorigenesis, kidney diseases, brain dysfunction, tooth fracture, ischemic reperfusion injury, hypertension, impaired reproductive system, and systemic acidosis. Carbonic anhydrases are...
Nanoparticles (NPs) have been studied as therapeutic drug-delivery agents for promising clinical trial outcomes. Nanomaterial-based drugs can transfer conventional drugs to target lesions, such as tumors, with increasing efficiency by enhancing drug-cell interaction or drug absorption. Although they are favorable as efficient drug transfer systems,...
Secretory glands including salivary glands by many hormonal inputs produce and secrete biological fluids determined by variety of ion transporters. Spinophilin is a multifunctional scaffolding protein, which involved in receptor signaling and regulation of anion exchangers AE2 activity. We found that spinophilin expressed in salivary glands. The ro...
The cholinergic receptor agonist carbachol (1 μM)-evoked intracellular Ca2+ signals with and without BAPTA-AM (BAPTA, 10 μM) in SMG acini (A) and ductal (B) cells. Arrows represent the applied time of agents. (C) The effect of acute carbachol with and without BAPTA-AM (10 μM) on CBE activities of SMG ductal cells. (D) Bars indicate the means ± SEM...
The pH calibration curve for (A) HEK293T, (B) A549, and primary isolated SMG (C) acini and (D) ductal cells at pH 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, and 8.5.
Expression of NBCe1 (red) and NKCC1 (red) in isolated SMG cells. The polyclonal NBCe1 antibody can recognize shared epitope on the NBCe1-A, -B, and -C isoform. (B) The interaction between NBCe1-B and SPL. Input blots were for loading control. (C) The interaction between NKCC1 and SPL. Input blots were for loading control. (D,E) The slope of pHi mea...
Citations
... The ubiquitinproteasome system (UPS), involved in SMC inflammation and phenotypic switch, is important in the common pathogenesis of aneurysms [50] and BS [80]. MLCK also intervenes in UPS regulation [81]. ...
... The DGKH gene has been identified previously as differentially expressed in sarcoidosis [66]; however, it has not been found in association with severe COVID-19. SLC26A6 is translated into a protein that regulates the concentrations of multiple anions in the cell [67,68], and may be affected during oxidative stress [69]. ...
... Ca 2+ signaling is deregulated in several types of cancers [5,6]. In different types of cancers including breast cancer, changes in the expression and activity of entities, such as ion channels, transporters, and their regulators [7,8] have been proposed as tumorigenic events that lead to malignancy. Altered Ca 2+ homeostasis increases cell motility and invasion, proliferation, apoptosis resistance, and changes in gene transcription (as reviewed by Monteith et al. (2017) [6]). ...
... This will inhibit the growth and proliferation of the parasite. Several studies described that the subtle pH changes in other acidic organelles, such as the lysosome caused the significant decrease in lysosomal enzyme activities, thus causing various pathological alterations (54)(55)(56). The increase of only a few tenths of a pH unit might have a major impact on the lysosomal function, whereas the organelle needs to maintain its acidic pH condition as in the digestive vacuole for the optimal activity of proteases (57). ...
... Hwang et al. demonstrated that cancer cell migration was regulated by extracellular modulation through bicarbonate transporters, including anion exchanger 2 (AE2) and sodium bicarbonate cotransporter-n1 (NBCn1) [42,43]. Bicarbonate plays a role in intracellular pH maintenance to regulate physiological functions [44]. The activation of AE2 or NBCn1 transports bicarbonate ions, and the electrolyte flux was reported to induce ...
... Several studies have documented that the acute neurotoxic effect of aluminaNPs was attributed to their ability to cause mitochondrial dysfunction and disruption of brain energy homeostasis, such as Na + , K + -ATPase activity [87], which play key roles in metabolism in neurons and postsynaptic calcium response [88]. These results imply that aluminaNP-induced ATPase dysfunction has profound effects on the modulation of neuronal plasticity and NMDA-evoked currents [89,90]. Specifically, aluminaNP-induced reactive oxygen species can modify the biological properties of the membrane [71,91,92], impair normal cellular function [93,94], and generate new oxidized products that can damage other macromolecules [93,95,96], thus leading to neuronal hyperactivity and synaptic dysfunction. ...
... In this study, although attenuation of SPL protein did not modulate expression of EMT proteins, reduced tight junctional protein ZO-1 and enhanced NBC activity were observed. We previously reported that SPL did not modulate NBC activity (Lee et al., 2018). NBCn1 has been reported to function as the migratory machinery in cancer cells (Hwang et al., 2020). ...
