January 2025
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Publications (7)
December 2024
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10 Reads
Asian Journal of Chemistry
Novel antimicrobial drugs are required to fight the serious global health challenge of antibiotic resistance. In this study, 12 hybrids ofdiarylsulfide (DAS) piperazine-amide 8a-l were synthesized. All the 12 compounds were assessed for the antibacterial study againstGram-positive and Gram-negative bacteria. Antibacterial structure-activity relationship (SAR) analysis revealed that disubstitutedcompounds, particularly 8h (3,4-dinitro) and 8j (2,4-dichloro), exhibited superior antibacterial activity and also states that ortho-substitutedcompounds performing better than para-substituted ones. Molecular docking studies further strengthened antibacterial efficacy ofdisubstituted compounds 8h (-7.58 kcal/mol) and 8j (7.14 kcal/mol) exhibited the highest binding affinity to the DNA gyr. A enzyme,interacting with essential residues critical for bacterial DNA replication. It was concluded that strong binding, alongside favourable lowerRMSD values, allows these compounds to effectively inhibit DNA gyrase. Therefore, these DAS piperazine-amide compounds representpromising lead compounds for further study as antibacterial agents.
October 2024
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5 Reads
January 2023
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129 Reads
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1 Citation
RASAYAN Journal of Chemistry
In pursuit of a biodynamically potent molecule, we have attempted to synthesize derivatives of piperazine by incorporating them into the Rosuvastatin intermediate. The reason behind this is that heterocyclic compounds with nitrogen atoms in their ring structure, such as pyrimidine, have great potential as drug design scaffolds. By doping piperazine into the Rosuvastatin intermediate, a series of new derivatives made up of aryl-amides, acetamides, and sulfonamides were produced. These derivatives were then assessed for their antimicrobial activity, with a few showing promising results.
December 2022
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39 Reads
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1 Citation
Aim: Cholinesterase inhibitors and radical scavengers have been recognized as powerful symptomatic anti-Alzheimer's disease agents. Hence, the present study aimed to develop new triazineamides as potent anticholinesterase and antioxidant agents. Methods: Triazineamide (7a–i) derivatives were synthesized using cyanuric chloride via nucleophilic substitution followed by condensation. Ellman assay, 2,2-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) radical scavenging assay and molecular docking studies with Autodock 4.2.3 program were conducted. Results: Triazineamide 7c was assessed as a potent, selective and mixed-type dual inhibitor of acetylcholinesterase, with and IC 50 of 5.306 ± 0.002 μM, by binding simultaneously with the catalytic active and peripheral anionic sites of acetylcholinesterase, and it had strong 2,2-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) radical scavenging abilities. Conclusion: These results suggest that triazineamides may be of interest to establish a structural basis for new anti-Alzheimer's disease agents.
May 2022
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318 Reads
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5 Citations
Pharmaceutical and Biomedical Research
Background: Since time immemorial, humans have identified several herbs to treat various ailments. With the advancement of science and state-of-the-art technologies, different herbal extracts and chemical constituents of herbs were identified as therapeutic targets. Cyperus rotundus, also called mustaka, is one of the most ancient herbs widely distributed in tropical and subtropical regions across the globe. The tuberous and aerial parts of the herb were identified to possess various pharmacological properties. Objectives: This review focuses on the various phytocompounds of mustaka and how these compounds exert pharmacological effects and their mode of action. The molecular and cellular effects of mustaka were also discussed based on the preclinical and clinical reports available using an array of in vitro, in vivo, and ex vivo methodologies. Methods: The information from Google Scholar, Science direct, PUBMED, were reviewed with a special focus on the mode of action of C. rotundus from the data on animal and preclinical experiments to treat various diseases. Conclusion: Based on the literature available on C. rotundus in Google Scholar, Science Direct, and PubMed, the pharmacological properties of mustaka were reviewed with a particular focus on its neuropharmacological activities. The mode of action of C. rotundus and its bioactive metabolites at the molecular biology level were demonstrated based on animal and preclinical experiments to cure various ailments. These diverse effects prove C. rotundus as a valuable traditional medicine for treating various disorders.
February 2020
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125 Reads
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2 Citations
Humans experience different kinds of stress as a part of the day to day activity. The manifestation of stress will aggravate based on the physical conditions of individuals and due to their socio-economic situation of living. Herbal extracts have long been used in the traditional systems of medicine for the treatment of various ailments because of their potent antioxidant activity and lesser or no side-effects. Recently, there is a surge of interest toward the search of natural substances with diverse pharmacological activities, that can scavenge free radicals and protect cells from oxidative damage and apoptosis because of the adverse effects associated with the use of conventional medicines. Celastrus paniculatus is an endangered medicinal plant used from years in the traditional Ayurvedic system of medicine. The review presents the diverse chemical constituents of C. paniculatus and their pharmacological actions such as neuroprotective, memory-enhancing, anti-depressant, anxiolytic, anti-aging, hypolipidemic, anticancerous, analgesic, anti-inflammatory, antioxidant, anti-apoptotic, gastroprotective, anti-ulcerative properties at the cellular and molecular level based on the pre-clinical and clinical reports available. In the present review, we gathered the information from sources such as Google Scholar, Science direct, PUBMED, and reviewed with a special focus on the mode of action of C. paniculatus at molecular biology from the data on animal and preclinical experiments to cure various ailments. These diverse medicinal values of C. paniculatus demonstrates its value as traditional medicine as a cure for multiple maladies.
Citations (4)
... Because of their numerous potential uses in scientific fields like synthetic and medicinal chemistry, natural Chalcones and their synthetic derivatives have garnered a lot of interest. 1,2 These are useful intermediates in organic synthesis from a chemical perspective, and when basic catalysis is present, they can function as activated unsaturated systems in the conjugated addition reaction of carbanions. 3,4 Utilizing this kind of reaction could lead to the production of derivatives of cyclohexenone that are highly functionalized 5,6 Chalcones have a remarkable range of biological activities linked to them, such as blood platelet anti-aggregating activity and antitubercular, antiparkinson, antitubercular, anti-inflammatory, anticancer, antiasthmatic, antibacterial, and antihypertensive properties. ...
- Citing Article
- Full-text available
January 2023
RASAYAN Journal of Chemistry
... 37 Following the docking processes, the obtained poses were analyzed. 38,39 RESULTS AND DISCUSSION ...
- Citing Article
- Full-text available
December 2022
... The rhizomes of this plant are considered one of the best medicines in Ayurveda (ancient and ancient science) and its Ayurvedic name is Nagamotha [14]. This plant is used to treat stomach and intestinal disorders, inflammatory diseases, menstrual irregularities, cancer, aging, atherosclerosis, pain, cystitis (bladder inflammation), prostatitis (prostate inflammation), arthritis, malaria, seizures, obesity, diarrhea, diabetes mellitus, and allergies [15,16]. Since stress is one of the undesirable characteristics of current societies and the use of medicinal plants has increased due to their safety and effectiveness in preventing and treating chronic diseases, and due to the effect of C. rotundus on memory in traditional medicine and the lack of reports of side effects, the current study was conducted to investigate the impacts of hydroalcoholic extract of C. rotundus rhizome on memory impairment caused by elevated platform. ...
- Citing Article
- Full-text available
May 2022
Pharmaceutical and Biomedical Research
... The mortality in India due to CKD is approximately 0.2 million [4]. Several medicines and medical procedures are available Since the inception of human civilization, flora has been continuously exploited for numerous medicinal and nonmedicinal applications across the globe [5][6][7]. More than 80 % of the population from developing and under-developed countries still rely on medicinal plants for their primary health care needs (WHO) [8][9][10][11][12][13]. ...
- Citing Article
February 2020