Dimitrios Laskaris's research while affiliated with Netherlands Cancer Institute and other places

Publications (2)

Article
Full-text available
The morphology and functionality of the epithelial lining differ along the intestinal tract, but tissue renewal at all sites is driven by stem cells at the base of crypts1–3. Whether stem cell numbers and behaviour vary at different sites is unknown. Here we show using intravital microscopy that, despite similarities in the number and distribution...
Article
Full-text available
Direct targeting of the downstream mitogen-activated protein kinase (MAPK) pathway to suppress extracellular-regulated kinase (ERK) activation in KRAS and BRAF mutant colorectal cancer (CRC) has proven clinically unsuccessful, but promising results have been obtained with combination therapies including epidermal growth factor receptor (EGFR) inhib...

Citations

... Aberrant activation of the ERK pathway is involved in the progression of a variety of tumors and affects several cellular processes such as cell proliferation, cell survival, and metastasis. [42][43][44][45] DUSP2 primarily functions to inactivate ERK via direct dephosphorylation of threonine and tyrosine residues. 46,47 In fact, the lack of DUSP2 expression and the activation of ERK signal has been proved in many types of cancer, however, the molecular mechanism is not clear. ...