Dilipkumar Pal’s research while affiliated with Guru Ghasidas Vishwavidyalaya and other places

Secondary metabolites present in different natural resources possess multiple biological activities. Diabetes is one of the leading disease all over the world in current time, and higher in numbersthan the deadliest cancer disease. According to the WHO about 422 million people are suffering from diabetes and most of them are even unaware that they are living with the condition. In recent times research in natural medicinal plants has achieved a great success in the management of different diseases and disorders. Moringa oleifera is one of the most common medicinal and nutritious plant among the family of moringaceae, found in almost all over India. The tree with it's almost every edible part makes it a versatile natural medicinal source. The secondary metabolites present within it make this plant a rich biological resource. Among various classes of secondary metabolites alkaloids, flavonoids, glycosides, terpenoids, sterols etc. are present in moringa tree. The principle potent compound responsible for emerging antidiabetic property of Moringa is 4-(α-Lrhamnopyranosyloxy) benzyl glucosinolate. In this review we summarise specifically the antidiabetic activity of this multipurpose natural plant and it's phytochemistry. Since ancient times this plant has been used as anti-diabetic agent in sub continental regions. Mostly phytoconstituents obtained from leaves are responsible for its outstanding antidiabetic property. Research on antidiabetic property of M. oleifera by different scientists proved that Moringa is one of the finest natural medicinal plants in the management of diabetes with least toxicity.

In modern times, researches on cancer are increasing at a huge rate focusing to prevent and treat cancer by natural resources. There are so many healthy fruits that belong to different families having good nutritional effects as well as potency to control different health issues. Apple and honey peach fruits belong to Rosaceae family subsumed their name in the management of cancer due to antiproliferative properties of their seeds. This book chapter elaborately describes the morphology, chemistry, antiproliferative properties, and toxicity of apple and honey peach seeds. Morphological and chemical analysis revealed significant differences in the two seed types. Both seeds were found to contain high levels of polyphenolic compounds, with apple seeds containing higher levels of flavonoids and honey peach seeds containing higher levels of phenolic acids. In vitro studies showed that both apple and honey peach seeds exhibited significant antiproliferative activity against several cancer cell lines. However, toxicity studies revealed that the seeds could cause cytotoxic effects on normal cells at high concentrations. These findings suggest that apple and honey peach seeds may have potential as sources of natural compounds with anticancer properties, but further research is needed to assess their safety and efficacy for therapeutic use.

Papaya seeds (PSs) are healthy, delicious, and rarely used. Moderate consumption of these tiny, spherical seeds is beneficial for menstruation pain, cancer, and weight loss. Heart-friendly too. PSs cleanse, hydrate, reduce inflammation, and improve digestion. PSs contain fiber, protein, and fat. Minerals and vitamins abound. Carotenoids, glucosinolates, isothiocyanates, and tocopherol are extensively studied as antiproliferative agents against cancerous cells and for modifying cell signaling, preventing proliferation, inducing apoptosis, and preventing migration, invasion, and angiogenesis. Papaya seed chemicals initially boost Th1-type cytokine production. Papaya suppresses hematopoietic cells such as Jurkat, ARH77, Raji, Karpas-299, and HL-60. Papaya decreases renal cell cancer. Papaya extracts affect cancer cells. PSs inhibit IL-6, TNF-α, PC-3, and MCF-7 cancer cells. PSs were effective against colon, leukemia, lung, liver, breast, and prostate cancer.. Papaya extract destroys cancer cells in vitro. This chapter highlights PSs’ plant-based compounds and antiproliferative properties on cancer cell lines.

Since the dawn of time, medicinal plants have been the foundation of health care around the world. Large-scale dietary changes have been observed recently due to the homogeneity and urbanization of eating behaviors, which has led to a reduction in the diversity of our global food system. The way we think about the food system has changed, and now we prioritize more food at cheaper rates. It is crucial to realize that dietary diversity ensures a balanced supply of the missing nutrients in the diet, supporting optimum nutrition. Life requires carbohydrates, fats, fiber, and protein. The fruit intake recommendations can be easily met by eating prunes and dates. The distinct range of phenolics, flavonoids, anthocyanins, and minerals included in prunes and dates may contribute to their positive impact on human health. The proximate composition, mineral, vitamin, and phytochemical contents of prunes and dates are critical for determining their nutritional relevance. The chemical composition of the feed determines its potential nutritive value as well as feed quality. Because many medical plant species are also consumed as food in addition to their medicinal effects, determining their nutritional significance can aid in determining their value. Moreover, in vitro and in vivo evaluation have been justified to validate prunes and dates as efficient foods for the purpose of preventing and treating cancer. The fruit and seeds of prunes and dates are rich in antioxidant elements, but they have not yet been thoroughly evaluated as potential functional food ingredients for antiproliferative agents.

This investigation was conducted to evaluate the antimicrobial effectiveness of the agar disc diffusion method and to determine the inhibition zone of Curcuma amada (CA) rhizome extracts (petroleum ether, dichloromethane, and chloroform) against 12 bacterial species and 4 fungal species. The inhibition zones of the extracts were compared to those of Ciprofloxacin and Griseofulvin for antibacterial and antifungal activities, respectively. The findings revealed that the organisms under examination showed significant inhibition of bacterial as well as fungal development during the experiment and that the typical form of C. amada rhizome can be used to treat bacterial and fungal illnesses. So, this plant could be used to find natural compounds that are bioactive and could be used to make new medicines.