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January 1984
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1,060 Reads
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4,404 Citations
Archives of Toxicology
A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is described. Using this, it is possible to obtain with 13 experimental animals adequate information on the acute toxicity and on the LD50. This method has no limitations and applies to drugs, agricultural and industrial chemicals. It can be used for every route of administration.
... The oral acute toxicity of Z. gilletii was assessed using the Lorke (1983) method. In the initial phase, mice (n=3) were administered graded doses (10, 100, and 1,000 mg/kg) of Z. gilletii extract, while in the phase-2, mice (n=1) were treated with higher doses (1,600, 2,900, and 5,000 mg/kg) of the extract. ...
January 1984
Archives of Toxicology
