Diego Montenegro's research while affiliated with City University of New York - Hunter College and other places

Publications (4)

Article
Full-text available
Background: Angelica sinensis is a medicinal plant known for a variety of biological effects, including its ability to stimulate innate immune cells in humans. Recent studies indicate that the immunostimulatory activity of A. sinensis arises from microbe-associated molecular patterns (MAMPs) of plant-associated bacteria. However, it is unknown whic...
Article
Juzen-taiho-to (JTT) is an immune-boosting formulation of ten medicinal herbs. It is used clinically in East Asia to boost the human immune functions. The active factors in JTT have not been clarified. But, existing evidence suggests that lipopolysaccharide (LPS)-like factors contribute to the activity. To examine this possibility, JTT was subjecte...
Article
Juzen-taiho-to is an immunostimulatory herbal formulation that is clinically used in East Asia for cancer patients undergoing chemotherapy and radiation. The formulation stimulates various leukocytes, including T, B, and NK cells and macrophages. Although Juzen-taiho-to is known to contain numerous compounds with various pharmacological activities,...
Article
The tetrahydrofuran (THF) containing annonaceous acetogenins (AAs) are attractive candidates for drug development because of their potent cytotoxicity against a wide range of tumors and their relatively simple and robust structures. Replacement of the THF segment with a sugar residue may deliver analogues with improved tumor selectivity and pharmac...

Citations

... This supports previous research where Pugh et al. (2008) attributed the majority of immune enhancing botanicals' in vitro macrophage activating properties to the presence of both LPS and bacterial lipoproteins acting through TLR4 and TLR2, respectively [43]. In addition, extracts from specific botanicals, including Angelica sinensis, Ashwaganda, and Echinacea purpurea have been shown to have immune stimulatory activity linked to plant-associated bacteria [44,[84][85]. Furthermore, there may be other synergistic ...
... However, while vegetable leaves are well populated with bacteria including potential probiotic acting Lactobacillus strains [34][35][36][37], so far, plant-derived produce has only been considered as vehicles of probiotic cultures [38,39]. A detailed understanding of how probiotic bacteria colonize leafy vegetables or herbs would enable future approaches to enrich these tissues with the respective bacterial strains to elevate vegetable leaves beyond their basic nutritional values. ...
... Many studies observed that plant extracts stimulated matured DCs to increase Tcell proliferation and production of immunostimulatory cytokines such as the T helper cytokines (Th1) IL-12 and IFN-γ [49], which are shown in Table 3. The extract of the Kurosengoku Japanese soybean initiates the production of IFN-γ and IL-12 from DCs [50]. Another group found that the active component galactomannan isolated from the Caesalpinia spinosa plant gives rise to the maturation of DCs and also increases mRNA levels of proinflammatory cytokines [51]. ...
... However, the studies on competitive inhibition showed that the core modification led to a different mechanism of action, even though the mitochondrial complex I remained the target [86]. One of the interesting novelties in the synthesis method described above is the incorporation of an aryloxy group at the end of the chain instead of γ-butyrolactone, something that had been previously tested on both sides of the chain by the same research group, which synthesized a bullatacin mimic structure without relevant results with regard to the inhibition of the mitochondrial complex I [87]. On the other hand, the introduction of biotin instead of aryloxy groups exhibited comparable IC50 inhibition values of the same mitochondrial complex, with 3.9 nM of the mimic versus 1.8 nM of the actual bullatacin [88]. ...