Diana L Glennie's research while affiliated with McMaster University and other places

Publications (7)

Article
The ability to monitor changes in the concentration of hemoglobin in the blood of the skin in real time is a key component to personalized patient care. Since hemoglobin has a unique absorption spectrum in the visible light range, diffuse reflectance spectroscopy is the most common approach. Although the collection of the diffuse reflectance spectr...
Article
Full-text available
The measurement of changes in blood volume in tissue is important for monitoring the effects of a wide range of therapeutic interventions, from radiation therapy to skin-flap transplants. Many systems available for purchase are either expensive or difficult to use, limiting their utility in the clinical setting. A low-cost system, capable of measur...
Article
Background: The time until maximal cutaneous vasoconstriction after injection of lidocaine with epinephrine is often given in textbooks and multiple choice examinations as 7 to 10 minutes. However, in our experience, there is significantly less cutaneous bleeding if one waits considerably longer than 7 to 10 minutes after injection of local anesth...
Article
Purpose: To quantitatively characterize the time sequence of skin erythema in head and neck patients undergoing intensity modulated radiation therapy(IMRT)treatments using optical reflectance spectroscopy. The overall goal is to identify patients who will develop extreme skin responses earlier than is possible by visual inspection alone. Methods: T...
Article
The prescribed radiant exposures for photodynamic therapy (PDT) of superficial skin cancers are chosen empirically to maximize the success of the treatment while minimizing adverse reactions for the majority of patients. They do not take into account the wide range of tissue optical properties for human skin, contributing to relatively low treatmen...
Article
The treatment of superficial skin cancers with photodynamic therapy (PDT) relies on uniformly covering the treatment target with sufficient light fluence using an externally applied source. Incorporating an integrating sphere into the treatment procedure makes this easier to achieve. A prototype sphere was characterized using a 1% Intralipid phanto...

Citations

... However, simulation studies have shown that within the 520-580 nm region, the error in measurements by not accounting for scattering of light is very small. 29 Our technology offers an additional advantage to overcome the impact of skin colour (melanin) during the estimation process. We have validated our algorithm to account for melanin effect on Hb measurements. ...
... En este trabajo se utilizó la aproximación propuesta por Glennie et Al. [323] para determinar el Indice del Eritema de Dawson a partir de mediciones de DRS. Este parámetro se calcula como elárea bajo la curva del negativo del logaritmo base 10 del espectro de la reflectancia difusa (conocido como la absorbancia aparente y expresado por la ecuación 4.6 en un rango de 650 − 700nm, y de igual forma que para el indice de melanina, descartando las contribuciones de la deoxy-Hb y la oxy-Hb. ...
... In radiation therapy, erythema reactions resulting from skin exposure to ionizing radiation also known as radiation dermatitis is a common limiting factor. Unchecked, severe radiation dermatitis can lead to intense pain, skin ulcers and tissue necrosis resulting in treatment interruptions and reduced quality of life [8][9][10][11]. Early assessment of radiation induced erythema can facilitate more timely interventions; it may help reduce patient discomfort, increase compliance with treatment and improve treatment outcomes [10]. ...
... In our cohort, excessive intraoperative bleeding was not a common occurrence. As described by McKee et al, 9 delaying the procedure by 25e30 minutes after epinephrine administration minimized bleeding and provided adequate hemostasis. Gauze may also be inserted into the canal to wick away bleeding and permits the surgeon to continue the operation safely with adequate visualization. ...
... 28,38 In summary, it has a low demand for computing power and thus provides fast convergence for a wide range of applications. For example, it has been applied successfully to real-time light dosimetry during photodynamic therapy (PDT) of superficial skin cancers, 39,40 differentiation between pigmented skin lesions (including malignant melanoma), 41 and to determine blood oxygen saturation levels faster, and over a larger area than existing methods with equivalent reliability. 42 However, it suffers from a number of limitations, in part because it relies upon approximate solutions to an equation that itself represents an approximation to the equation of RTT. ...