Di Wu's research while affiliated with Sun Yat-Sen University Cancer Center and other places

... Precisely, PRMT1 and PRMT7 interact with YY1 to regulate the expression of specific genes [33,56]. Besides, YY1 could transcriptionally activate PRMT5 and aid in proliferation and invasion in laryngeal cancer cells [57]. With our observation on the close association between PRMT5 and YY1, it would be worthwhile in future to study the association of YY1 with other distinct methyl transferases during mycobacterial infection. ...

... Silver staining was performed using the Fast Silver Stain Kit (Beyotime) and mass spectrometry was carried out by Novogene, in Beijing, China. Immunoblotting assay was performed as previously described [17]. Antibodies specific to human proteins were anti-PRMT5 (ab109451, Abcam), anti-G3BP2 (16276-1-AP; Proteintech and ab86135; Abcam), anti-Flag (9A3; Cell Signaling Technology), anti-α-Tubulin (T6074, MilliporeSigma), anti-USP7 (4833 S, Cell Signaling Technology), anti-ACLY (4332, Cell Signaling Technology), anti-FASN (3180, Cell Signaling Technology), anti-PPARγ (33436 M, Bioss Antibodies), anti-SCD1 (3787 R, Bioss Antibodies), anti-nSREBP1 (ab159577, Abcam) anti-ELOVL6 (ab69857, Abcam), anti-ACSL3 (ab151959, Abcam) and anti-methy-G3BP2 was a custom-made polyclonal antibody. ...

... Other redox-sensitive linkages include diselenide bonds (Se-Se), succinimidethioether linkage, and trimethyl-locked benzoquinone [186,193,194]. Though most of these formulations are used to deliver a single drug, a few multi-drug-loaded nano-carriers have been prepared [195][196][197]. For example, Sun et al. developed a redox-responsive immunostimulatory polymeric prodrug carrier (PSSN10) by conjugating an immune checkpoint blocker NLG919 (IDO inhibitor) with a (butyoxycarbonyl) cystamine-based polymer through a redox-responsive linkage [56]. ...

... Radiotherapy (RT), either for curative or palliative purposes, is administered to about 80% of HNC patients. Irradiation of the primary or secondary HNC, like any other tumor site, has been linked to an increase in the prevalence of secondary HNCs (5)(6)(7). A sizable proportion of patients suffer from severe radiation-related complications despite significant improvements in RT planning and delivery methods (8). ...

... Reliable diagnosis and effective targeted therapy are important; therefore, multifunctional nanotherapeutic agents show great potential for therapeutic and diagnostic applications in various diseases [75]. Interestingly, the fluorescence properties of drug delivery systems enable the simultaneous tracking and monitoring of drugs, which is very promising for drug delivery and targeted therapy [76]. ...

... Uma reconstrução ideal fornece um retalho flexível e que pode substituir a pele da face com uma boa combinação de cor, textura e ser capaz de cobrir tanto pele mais delicada quanto defeitos profundos 1 , além de garantir qualidade em relação à vascularização do tecido doado. Dentre as principais vantagens, podem ser destacados fatores relacionados à cicatriz de área doadora inconspícua, técnica simples e reprodutível, tempo cirúrgico curto, uso em pacientes com diversas comorbidades, retalho fino e glabro, cor semelhante da vizinhança a ser reconstruída 6,7,8,9,10,11,12,13 . Apresentamos um caso em que a paciente foi submetida à reconstrução facial utilizando tecido supraclavicular pré-estendido pós fasceíte necrotizante na face. ...

... PTK6 expression was found to be at a lower level in laryngeal squamous cell carcinoma tissues than in the neighboring noncancerous epithelial laryngeal tissues, and survival experiments demonstrated that PTK6 expression was a possible predictive factor for survival in laryngeal squamous cell carcinoma patients. Patients with laryngeal squamous cell carcinoma who had high expression levels of PTK6 had an overall and disease-free survival rate that was more favorable [33]. On the other hand, the roles of PTK6 in BC remained unknown for the most part. ...

... Posttraumatic defects of the facial skeleton, or bone defects following tumor removal are usually associated with soft tissue support deficit, resulting in facial asymmetry, enophthalmos, lagophthalmos with secondary conjunctivitis, the loss of tooth-bearing segments, and speech impairment (1). All lead to a lower quality of life for the patient. ...

... This finding directly indicates that TLR activation can promote megakaryocyte maturation and platelet formation through the downstream pathways. When TLR4 is activated by its natural agonist LPS, it leads to the activation of JAK-2 and STAT-5 and induces macrophages to secrete the inflammatory cytokine IL-6, which is also a positive regulator of megakaryocyte formation [109,110]. In addition, TLR2 activation can also stimulate Meg01, which can promote the activation of the TLR downstream pathways and subsequent megakaryocyte maturation [64]. When Dami cells were treated with heat-killed lactic acid bacteria HKL (1 g/mL), another TLR2 ligand, for 24 h, their expression levels were detected by qPCR, which showed that the expression of TLR in the stimulated group increased 5-fold, and the expression of megakaryocyte maturation markers CD41 and CD61 also increased [54]. ...

... c-Mpl-k possesses an alternate intracellular domain and c-Mpl-tr is a prematurely truncated isoform, with potentially both acting as dominantnegative isoforms of the receptor [23,26]. Previous studies also have shown that the c-Mpl-del isoform which encompasses a 24 amino acid deletion between exons 8 and 9 in the extracellular region was detected in CD34+ cells, megakaryocytes, and F. Li et al. platelets isolated from healthy donors and essential thrombocythemia (ET) patients as well as megakaryocytic leukemia cells [27][28][29]. The presence of c-Mpl-del might reflect the stable adaptive regulation for megakaryocyte development and abnormal expansion of hematopoietic cells by having different roles in physiological and pathological functions. ...