Dheeraj Bisht’s research while affiliated with Kumaun University and other places

... Research into these plants has also emphasized the need for clinical validation of their efficacy in managing cardiometabolic risk factors, particularly those associated with obesity and CVD. The development of therapeutic strategies utilizing Lamiaceae plants holds promise for addressing these health concerns [7,12]. Ongoing studies and patent analyses are essential to uncover the full potential of these plants in naturopathic and biomedical applications [13]. ...

Reference:

Lamiaceae Plants and Cardiovascular Health: A Patent-Driven Path to Functional Foods

... shown that P. attenuatum exhibits antibacterial, anticancer, antidiabetic, anti-inflammatory, antipyretic, diuretic, hepatoprotective, and hyperlipidemic activities [7]. ...

Reference:

IL-6 Inhibitory Compounds from the Aerial Parts of Piper attenuatum and Their Anticancer Activities on Ovarian Cancer Cell Lines

... The reliance on visible tumor characteristics renders conventional approaches like magnetic resonance imaging, biopsy, and ultrasound insufficient for the initial diagnosis of cancer [2]. Development and advancement of tumours are linked to a complex range of genetic or epigenetic abnormalities that interfere with cellular signaling, resulting in the formation of tumours and malignancy [3]. The National Cancer Institute (NCI) defines a biomarker as a biological molecule present in blood, other bodily fluids, or tissues that indicates a normal or abnormal process, condition, or disease. ...

Reference:

Recent Advancements in Photodynamic Therapy and Cancer Biosensor using Natural Products

... For the next steps, the peak areas of both the standard curcumin and the sample curcumin were measured at 422 nm. This wavelength is aligned with those used in previous studies, which ranges from 415 to 430 nm (Oglah et al. 2020;Sogi et al. 2010;Wikara et al. 2016;Gantait et al. 2011;Gangal et al. 2023;Kushwaha et al. 2021). ...

Reference:

A Validated TLC-Densitometric Analysis of Curcumin in Eight Important Zingiberaceae Rhizomes and Their ATR-FTIR Fingerprint Profiles

... It is broadly classified into organic and inorganic nanocarrier systems based on composition (NCs). Organic NCs are widely used to increase the drug solubility, permeability, and bioavailability of antiviral medications, along with lipid carriers, metallic nanoparticles, nanoemulsion, polymeric nanoparticles, etc., [27][28][29][30][31][32][33][34][35][36]. The inorganic NCs have dimensions smaller than organic NCs, i.e., 1-100 nm, and comprise metallic nanoparticles, quantum dots, and plasmonic nanoparticles [37]. ...

Reference:

An Updated Review on the Alarming Epidemic of the Monkeypox Virus

... In the context of increasing antibiotic resistance attributed to the overuse of synthetic drugs, the need for alternative treatments is crucial. X. strumarium, which circulates in Iraq, has been reported to exhibit a range of pharmacological activities [45]. Its effectiveness against diseases Various parts of plants, especially fruits and roots, are used as treatments. ...

Reference:

Phytochemical Profiling and Antibacterial Dynamics of Xanthium strumarium L Extract: Unlocking Potential Therapeutic Pathways

... Materials like polycaprolactone (PCL), polyglycolic acid (PGA), and poly-L-lactic acid (PLLA) are used to produce biodegradable also bioresorbable implants and devices. [37] Hydrogels Hydrogels, which can contain a high-water content, are utilized in 3D bioprinting to form soft tissues and organoids for pharmaceutical research and regenerative medicine, [38] Nanoparticles Nanoparticles loaded with drugs can be incorporated into 3D-printed structures to achieve controlled drug release. [39] Silicone In 3D Printing, silicone materials are used to produce medical devices such as prosthetics, catheters, and seals. ...

Reference:

3D PRINTING IN PHARMACEUTICAL MANUFACTURING: AN OVERVIEW

... Recent investigations have focused on improving the well-being of patients during and after receiving chemotherapy (including those using Dox) and radiotherapy, by testing different treatments formulations, prodrugs, nanoforms, targeted forms, and organ protection strategies [11,[35][36][37] , highlighting the pressing need for improved, efficient, and less toxic approaches to oncology treatments. A c c e p t e d M a n u s c r i p t ...

Reference:

Preliminary investigation of organ-protective effects of fullerenol in vivo in acute toxicity during doxorubicin therapy in healthy pigs

... The outcomes demonstrated that PTX was delivered intracellularly with efficiency and that it significantly promoted CD44+ cell death in vitro. 175 Nanostructured lipid carriers: nanostructured lipid carriers (NLCs) showed their effectiveness in treating cancer as innovative medication carriers. Extensive use as carriers attributed to NLCs special properties that include improved drug integration, long-term chemical and physical stability of integrated active moiety, surface modifications and site-specific targeting. ...

Reference:

Navigating the Potential of Natural Products through Nano-enabled Drug Deliveries in Mitigation of Cancer: A Review

... Probiotic bacteria (Arya et al., 2022) participate in potent immunomodulatory activity by enhancing their host's antibody production, modulating NF-kB, inhibiting proteasome activity, and inducing regulatory T-cell repertoire (Jijon et al., 2004). Gut barrier integrity is one of the most critical conditions preventing the onset of gut-related diseases. ...

Reference:

Role of functional foods and nutraceuticals for depression, post-traumatic stress disorder, and suicidal behaviors