Debbie Penava's research while affiliated with The University of Western Ontario and other places

Publications (8)

Article
Full-text available
Background Assessment of fetal adipose tissue gives information about the future metabolic health of an individual, with evidence that the development of this tissue has regional heterogeneity.Objective To assess differences in the proton density fat fraction (PDFF) between fetal adipose tissue compartments in the third trimester using water-fat ma...
Article
Objective: This study sought to determine whether obese pregnant women undergo cesarean sections without an adequate trial of labour. This may affect future birth and pregnancy outcomes. Methods: A retrospective analysis was done on 526 parturients at Victoria Hospital in London, Ontario. Women were categorized according to parity and pre-pregna...
Article
Preeclampsia is a serious pregnancy condition defined as new-onset hypertension and proteinuria, commonly characterized as either early, ‘placental’, or late onset, ‘maternal’, using a cut-off of 34 weeks gestation. However, it may be more useful to differentiate between the vascular remodelling and placental invasion vs. inflammation and metabolic...
Article
This study assessed the strength of the association between socioeconomic status (SES) and low birth weight (LBW) and preterm birth (PTB) in Southwestern Ontario. Utilizing perinatal and neonatal databases at the London Health Science Centre, maternal postal codes were entered into a Geographic Information System to determine home neighbourhoods. N...
Article
One in four Canadian adults is obese, and more women are entering pregnancy with a higher Body Mass Index (BMI) than in the past. Pregnant women who are overweight or obese have a higher risk of pregnancy-related complications than women of normal weight. Gestational weight gain (GWG) is also associated with childhood obesity. Although the factors...

Citations

... Although not yet clinical, there are ongoing attempts to perform fetal and neonatal CSE MRI for assessment of liver PDFF as well as other body compartments [24]. Performing this technique in the fetus offers particularly unique challenges, including very small size of the liver, low signal-to-noise ratio, and motion artifacts (e.g., due to both maternal and fetal movement). ...
... These findings are consistent with prior research. 19,20 Differences by maternal age, BMI, and parity signal important directions for future study that might also examine whether maternal age modifies the relationship between first stage labour duration and BMI. 12 Given repeated evidence that normal labour durations vary widely, 15 that each labouring individual has multiple health and demographic characteristics, and that the effect of these characteristics varies, in turn, by other characteristics, unless future nomograms become exceedingly individualized, greater patience in labour, with less focus on time, may be prudent. A strength of this study is the sample, which provided the opportunity to study labour progress in a large, contemporary, low-risk, and undisturbed cohort. ...
... The role of sFlt-1 and PLGF in the identification of women with preeclampsia has been largely reported, and during pregnancy, the placenta secretes large amounts of PlGF and sFlt-1. As a decoy receptor for VEGF and PlGF, increased sFlt-1 binds to free VEGF and PlGF in maternal circulation and inhibits the biological actions of their membrane receptor (23)(24)(25). Studies by Cui et al. (26) showed that PlGF and sFlt-1 are important biomarkers for predicting the occurrence of preeclampsia and its complications. In addition, the result also showed that the sFlt-1/PlGF ratio is a useful triage tool for the pregnancy outcome of patients with PE, and its predictive performance is better than the individual marker. ...
... Socio-economic determinants have been consistently identified as distal risk factors associated with preterm birth. Socio-economic status (SES) is an important predictor of health disparities, since socio-economically underprivileged groups tend to have worse health outcomes 14 . The economic dimension, represented in particular by family income, education and occupation, plays an important role in the determination, and adverse results of pregnancy 15 . ...
... Suggestions for potential ways to handle the increasing rate of childhood obesity has been to include more professionals in health care and different parts of the community (Dalrymple et al., 2018). It has also been suggested that it is necessary to reach a larger target population, including the whole family, and to carry out the interventions multiprofessionally throughout the whole health care chain (Campbell et al., 2016). The becoming father, the spouse or a relative often joins the woman on her visits to antenatal care and was welcome to participate also on the extra visits concerning the project, but only a few used this possibility. ...