Debbie C. Crans's research while affiliated with Colorado State University and other places

Publications (8)

Article
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A major problem with patient treatments using anticancer compounds is accompanying bacterial infections, which makes more information on how such compounds impact bacterial growth desirable. In the following study, we investigated the growth effects of an anticancerous non-toxic Schiff base oxidovanadium(V) complex (N-(salicylideneaminato)-N′-(2-hy...
Article
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Menaquinones are a class of isoprenoid molecules that have important roles in human biology and bacterial electron transport, and multiple methods have been developed for their synthesis. These compounds consist of a methylnaphthoquinone (MK) unit and an isoprene side chain, such as found in vitamin K1 (phylloquinone), K2, and other lipoquinones. T...
Article
This review focuses on cytotoxic rhenium compounds in terms of IC 50 values, their mode of action in biological systems and their status in clinical trials. Biological studies of different rhenium compounds ordered by the oxidation state of rhenium are presented. Numerous rhenium complexes are reported, with the greatest number of compounds contain...
Article
Vanadium compounds have been known to have beneficial therapeutic properties since the turn of the century, but it was not until 1965 when it was discovered that those effects could be extended to treating cancer. Some vanadium compounds can combat common markers of cancer, which include metabolic processes that are important to initiating and deve...
Article
Full-text available
Oncolytic viruses (OV) are an emerging class of anticancer bio-therapeutics that induce antitumor immunity through selective replication in tumor cells. However, the efficacy of OVs as single agents remains limited. We introduce a strategy that boosts the therapeutic efficacy of OVs by combining their activity with immuno-modulating, small molecule...
Article
Full-text available
Vanadate and vanadium compounds exist in many environmental, biological and clinical matrices, and despite the need only limited progress has been made on the analysis of vanadium compounds. The vanadium coordination chemistry of different oxidation states is known, and the result of the characterization and speciation analysis depends on the subse...

Citations

... They concluded that catecholate Schiff base vanadium complexes are more effective than free catecholates as a result of the combination of catechol properties, including toxicity, hydrophobicity, and steric factors. Northcote-Smith et al. [3] reported polypyridyl and naphthol Schiff base copper complexes that are active against breast cancer stem cells by elevating the level of intracellular reactive oxygen species. The mixed ligands are 1,10-phenanthoroline and a tridentate (O, N, S) coordinated naphthol Schiff base ligand. ...
... It acts as cofactor for the γ-carboxylase enzyme. It exists in two forms, VK1 or phylloquinone and VK2/MK-n or menaquinones [16]. VK1 is found in plant sources, including green leafy vegetables and vegetable oils, while VK2 is abundant in animal-based and fermented products [17]. ...
... We would like to pay attention to the recently obtained first nitroxide-substituted derivative of cyrhetrene [41], that actually opened the opportunity of developing theranostics medicines on their basis. The therapeutic effect of radiological treatment with 186/188 Re [42,43] isotopes in such compounds can be combined with monitoring and diagnosis by magnetic resonance imaging (MRI), where a paramagnetic organic fragment acts as a contrast agent [44,45]. In this regard, the development of methods for the synthesis and study of the corresponding nitroxide-substituted cymantrene derivatives becomes of essential importance. ...
... By interfering with several phases of the cell cycle, β-carotene and lycopene have been shown to decrease tumor cell growth (Singh et al. 2012;Sliwinski et al. 2009;Cheng et al. 2021;Zhang et al. 2020a, b;Costello and Franklin 2014) Vanadium Breast, renal, liver, lung and GIT Inhibition of cellular tyrosine phosphatases and/or activation of tyrosine phosphorylases protects genomic instability. Both actions activate signal transduction pathways that lead to apoptosis and/or the activation of tumor suppressor genes DNA breakage and fragmentation as well as plasma membrane lipoperoxidation, can cause cell-cycle arrest and/or cytotoxicity (Singh et al. 2012;Crans et al. 2018Crans et al. , 2019Evangelou 2002) Magnesium Colorectal, liver and esophageal, breast, prostate and ovarian cancer Mg forms complexes with ATP, ADP and GTP and is required for the action of the glycolysis enzymes glucokinase, phosphofructokinase, and pyruvate kinase, which is known to be the preferred route for neoplastic cells to produce energy. Mg interacts with DNA polymerase, ribonucleases, adenyl cyclase, phosphodiesterase's, guanylate-cyclase, ATPases, and GTPases, and is therefore involved in nucleic acid and protein metabolism as well as signal transmission. ...
... This expands the scope of OVs to include the originally resistant tumors, further potentiating this promising therapy. In another study, investigators found that vanadium compounds can potentiate oncolytic immunotherapy though multiple mechanisms [304]. The compounds work by subverting the antiviral type I IFN response toward a death-inducing and pro-inflammatory type II IFN response, leading to improved OV spread, increased bystander killing of cancer cells, and enhanced antitumor immunity [304]. ...
... In the steel industry, vanadium/phosphate systems are used as corrosion inhibitors instead of hexavalent chromium [1]. Large amounts of vanadium are released into the environment and vanadium compounds have been shown to have deleterious effects on the circulatory system, can disrupt human metabolism, and lower dietary glucose, cholesterol and triglycerides in diabetic rats [2][3][4]. Therefore, vanadium is considered as a potentially dangerous contaminant. It has been included in the list of candidate pollutants by the EPA (Environmental Protection Agency of United States) [5,6]. ...
... Over the past several decades, tremendous scientific and technological progress has been made in the area of metal nanoparticles research. [1][2][3][4][5][6][7] Thanks to their small-size, large surface-to-volume ratio, and discrete energy levels, metal nanoparticles show bizarre physical and chemical properties and hold potential applications in a wide range of fields such as catalysis, magnetic sensing, optical detection, medical diagnosis, etc. Singularly, size, shape, and composition dependence of their properties offer key principles for tailoring and gauging their specific physical or chemical performances and technological functionalities. [2][3][4][5][6] Nevertheless, our knowledge about metal nanoparticles is still limited or incomplete. ...