David G. Cory’s research while affiliated with Institute for Quantum Computing and other places

Amyloidosis is a protein misfolding disease caused by the deposition of large, insoluble aggregates (amyloid fibrils) of protein in a tissue, which has been associated with various conditions, such as lymphoid disorders, Alzheimer's disease, diabetes mellitus type 2, chronic inflammatory processes, and cancers. Amyloid fibrils are commonly diagnosed by qualitative observation of green birefringence from Congo red stained biopsy tissue samples under polarized light, a technique that is limited by lack of specificity, dependence on subjective interpretation, and technical constraints. Studies emphasize the utility of quantitative polarized light microscopy (PLM) methodology to diagnose amyloid fibrils in Congo red stained tissues. However, while Congo red enhances the intrinsic birefringence of amyloid fibrillar structures, there are significant disadvantages such as the appearance of multiple non-green colors under polarized light and binding to other structures, which may result in misdiagnoses with Congo red dye and inconclusive explanations. In this work, we present an improved PLM methodology for quantitative detection of amyloid fibrils without requiring Congo red staining. We perform PLM measurements on four tissues: abdominal subcutaneous tissue biopsy, duodenal biopsy, thyroid biopsy, and breast biopsy, both with Congo red stain and H\&E stain, and through Fourier analysis quantify birefringence, birefringent axis orientation, dichroism, optical activity, and relative amyloid density. These results emphasize a quantitative analysis for amyloid diagnosis rooted in Fourier signal harmonics that does not require Congo red dye and paves the way for rapid, simple, and accurate diagnosis of amyloid fibrils.

Methods to prepare and characterize neutron helical waves carrying orbital angular momentum (OAM) were recently demonstrated at small-angle neutron scattering (SANS) facilities. These methods enable access to the neutron orbital degree of freedom which provides new avenues of exploration in fundamental science experiments as well as in material characterization applications. However, it remains a challenge to recover phase profiles from SANS measurements. We introduce and demonstrate a novel neutron interferometry technique for extracting phase information that is typically lost in SANS measurements. An array of reference beams, with complementary structured phase profiles, are put into a coherent superposition with the array of object beams, thereby manifesting the phase information in the far-field intensity profile. We demonstrate this by resolving petal-structure signatures of helical wave interference for the first time: an implementation of the long-sought recovery of phase information from small-angle scattering measurements.

Understanding the flow, loss, and recovery of the information between a system and its environment is essential for advancing quantum technologies. The central spin system serves as a useful model for a single qubit, offering valuable insights into how quantum systems can be manipulated and protected from decoherence. This work uses the stimulated echo experiment to track the information flow between the central spin and its environment, providing a direct measure of the sensitivity of system/environment correlations to environmental dynamics. The extent of mixing and the growth of correlations are quantified through autocorrelation functions of the noise and environmental dynamics, which also enable the estimation of nested commutators between the system/environment and environmental Hamiltonians. Complementary decoupling experiments offer a straightforward measure of the strength of the system Hamiltonians. The approach is experimentally demonstrated on a spin system.

Hybrid quantum systems consisting of a collection of N spin-1/2 particles uniformly interacting with an electromagnetic field, such as one confined in a cavity, are important for the development of quantum information processors and will be useful for metrology, as well as tests of collective behavior. Such systems are often modeled by the Tavis-Cummings model and having an accurate understanding of the thermal behaviors of this system is needed to understand the behavior of them in realistic environments. We quantitatively show in this work that the Dicke subspace approximation is at times invoked too readily, in specific we show that there is a temperature above which the degeneracies in the system become dominant and the Dicke subspace is minimally populated. This transition occurs at a lower temperature than priorly considered. When in such a temperature regime, the key constants of the motion are the total excitation count between the spin system and cavity and the collective angular momentum of the spin system. These enable perturbative expansions for thermal properties in terms of the energy shifts of dressed states, called Lamb shifts herein. These enable efficient numeric methods for obtaining certain parameters that scale as $O(\sqrt{N})$, and is thus highly efficient. These provide methods for approximating, and bounding, properties of these systems as well as characterizing the dominant population regions, including under perturbative noise. In the regime of stronger spin-spin coupling the perturbations outweigh the expansion series terms and inefficient methods likely are needed to be employed, removing the computational efficiency of simulating such systems. The results in this work can also be used for related systems such as coupled-cavity arrays, cavity mediated coupling of collective spin ensembles, and collective spin systems.

Psychophysical discrimination of structured light (SL) stimuli may be useful in screening for various macular disorders, including degenerative macular diseases. The circularly-oriented macular pigment optical density (coMPOD), calculated from the discrimination performance of SL-induced entoptic phenomena, may reveal a novel functional biomarker of macular health. In this study, we investigated the potential influence of eye dominance and testing order effects on SL-based stimulus perception, factors that potentially influence the sensitivity of screening tests based on SL technology. A total of 28 participants (aged 18-38 years) were selected for the study after undergoing a comprehensive eye examination. A psychophysical task was performed where various SL-based entoptic images with multiple azimuthal fringes rotating with a specific temporal frequency were projected onto the participants' retinas. By occluding the central areas of entoptic images, we measured the retinal eccentricity (R) of the perceivable area of the stimuli. The slope of the coMPOD profile (a-value) was calculated for each participant using a spatiotemporal sensitivity model that takes into account the perceptual threshold measurements of structured light stimuli with varying spatial densities and temporal frequencies. The Pearson correlation coefficient between eye dominance and testing order effects was r=0.8 ($p<0.01$). The Bland-Altman plots for both factors indicated zero bias. The results indicate repeatable measurements for both eyes, implying minimal impact from eye dominance and testing order on SL-based stimulus perception. The results provide a foundation for future studies exploring the clinical utility of SL tools in eye health.

The dichroic macular pigment in the eye acts as a natural radial polarization filter and enables humans to directly perceive polarization-related entoptic phenomena. Linearly polarized blue light induces a subtle bowtie-like pattern known as Haidinger’s brush in the central point of vision. The clarity and shape of this perceived pattern are directly linked to the health of the macula, rendering Haidinger’s brush a potential diagnostic marker in research on early-stage age-related macular degeneration (AMD) and central field visual dysfunction. However, due to the faint nature of this signal, integrating the perception of Haidinger’s brush into modern clinical methods remains a challenge. Here we review some advances in techniques to increase the strength of the perceived signal by employing polarization coupled orbital angular momentum states. We successfully achieved the creation of stimuli with higher numbers of azimuthal fringes, enabling the perception and discrimination of Pancharatnam-Berry phases, measuring the visual angle of entoptic phenomena, retinal imaging using structured light, and the creation of radially varying entoptic stimuli. Our current studies are focusing on applying the structured light methods that we developed to subjects that suffer from ocular diseases such as AMD.

The development of advanced spintronics materials necessitates novel characterization tools with the ability to analyze nanometer-scale spin textures. Neutrons, with their angstrom-sized wavelengths, electric neutrality, and controllable spin states, are uniquely suited for this task. Recent research has prioritized expanding the capabilities of the “neutron toolbox” to effectively characterize emerging materials. This involves the development of holographic and tomographic techniques for 3D characterization of bulk spin textures, alongside methods for creating structured neutron beams with specific spin-orbit states like helical and skyrmion configurations. Here we provide a concise overview of these advancements, exploring their potential future applications.

Perfect-crystal neutron interferometry, which is analogous to Mach-Zehnder interferometry, uses Bragg diffraction to form interfering neutron paths. The measured phase shifts can be used to probe many types of interactions whether it be nuclear, electromagnetic, gravitational, or topological in nature. For a perfect-crystal interferometer to preserve coherence, the crystal must possess a high degree of dimensional tolerance as well as being relatively defect-free with minimal internal stresses. In the past, perfect-crystal neutron interferometers have been produced by a two-step process. First, a resin diamond wheel would be used to remove excess material and shape the interferometer. Afterword, the crystal would be etched to remove surface defects and elevate strains. This process has had limitations in terms of repeatability and in maximizing the final contrast, or fringe visibility, of the interferometer. We have tested various fabrication and post-fabrication techniques on a single perfect-crystal neutron interferometer and measured the interferometer's performance at each step. Here we report a robust, nonetching fabrication process with high final contrast. For the interferometer used in this work, we achieved contrasts of greater than 90% several times and ultimately finished with an interferometer that has 92% contrast and a uniform phase distribution. Published by the American Physical Society 2024

Bipartite entangled states between a qubit and macroscopically distinct states of a mesoscopic system, known as micro-macro entangled states, are emerging resources for quantum information processing. One main challenge in generating such states in the lab is their fragility to environmental noise. We analyze this fragility in detail for single particle noise by identifying what factors play a role in the robustness and quantifying their effect. There is a trade-off between the macroscopicity of a micro-macro entangled state and the robustness of its bipartite entanglement to environmental noise. We identify symmetric micro-macro entangled states as the most robust states to single particle noise. We show that the robustness of bipartite entanglement of such states to single particle noise decreases as the second order of macroscopicity, which identifies a regime where the bipartite entangled state is both robust and macroscopic. Our result is a step towards retaining quantum characteristics on large scales and experimental realization of micro-macro entangled spin states and their use for connecting separated qubits. Moreover, it advances our understanding of quantum to classical transition.

The macular pigment (MP) in the radially-oriented Henle fibers that surround the foveola enables the ability to perceive the orientation of polarized blue light through an entoptic phenomena known as the Haidinger's brush. The MP has been linked to eye diseases and central field dysfunctions, most notably age-related macular degeneration (AMD), a globally leading cause of irreversible blindness. Recent integration of structured light techniques into vision science has allowed for the development of more selective and versatile entoptic probes of eye health that provide interpretable thresholds. For example, it enabled the use of variable spatial frequencies and arbitrary obstructions in the presented stimuli. Additionally, it expanded the 2{\deg} retinal eccentricity extent of the Haidinger's brush to 5{\deg} for a similar class of fringe-based stimuli. In this work, we develop a spatiotemporal sensitivity model that maps perceptual thresholds of entoptic phenomenon to the underlying MP structure that supports its perception. We therefore selectively characterize the circularly-oriented macular pigment optical density (coMPOD) rather than total MPOD as typically measured, providing an additional quantification of macular health. A study was performed where the retinal eccentricity thresholds were measured for five structured light stimuli with unique spatiotemporal frequencies. The results from fifteen healthy young participants indicate that the coMPOD is inversely proportional to retinal eccentricity in the range of 1.5{\deg} to 5.5{\deg}. Good agreement between the model and the collected data is found with a Pearson $\chi^2$ fit statistic of 0.06. The presented techniques can be applied in novel early diagnostic tests for a variety of diseases related to macular degeneration such as AMD, macular telangiectasia, and pathological myopia.