David B. Church’s research while affiliated with Royal Veterinary College and other places

Little information has been published on the recorded disorders of pet chelonia. This cohort study aimed to report on demography, commonly recorded disorders and mortality recorded in chelonia under UK primary veterinary care in 2019. Electronic health records on a random sample of chelonia in VetCompass during 2019 were reviewed to extract species, recorded disorder and mortality data. Of 2,040 chelonia reviewed, 1,923 (94.26%) were recorded as tortoises, 74 (3.63%) terrapins and 43 (2.11%) turtles. Of the 811 (42.17%) tortoises with species information recorded, the most common species were Hermann’s tortoises (Testudo hermanni) (311, 38.35%), Horsfield’s tortoises (Testudo horsfieldii) (259, 31.94%) and Mediterranean spur-thighed tortoises (154, 18.99%). The most commonly recorded disorders were beak abnormalities (16.72%), overgrown nails (11.47%) and shell abnormalities (9.80%). The most common recorded causes of death were “disorder undiagnosed” (44.55%), dog bite (5.45%) and anorexia (3.96%). Of 178 deaths with age recorded, the median age at death was 7.32 years (IQR 2.50-15.14). Short temporal windows within the clinical records and often limited clinical workups were a frequent limitation to the precision of the recorded disorder terms. This is the largest study of chelonia to date. It has highlighted the most commonly recorded disorders of chelonia of which many are often linked to husbandry.

Background Beagles are a popular companion animal dog breed and are generally stated to be a healthy breed. This VetCompass study aimed to report the demography, common disorders and mortality of Beagles under primary veterinary care in the UK. Anonymised clinical records within VetCompass were followed over time to extract disorder and mortality data during 2019 on Beagles under primary veterinary care in the UK. Results Beagles comprised 19,906 (0.88%) of the 2,250,417 dogs in the study population. Annual proportional birth rates showed an increasing breed popularity from 0.41% of all dogs born in 2005 and peaking at 1.06% in 2012, followed by a decrease to 0.90% in 2019. The median adult bodyweight was 18.19 kg (IQR 15.68–21.07). From a random sample of Beagles (3,729/19,906, 18.73%), the most diagnosed disorders were obesity (24.27%, 95% CI: 22.89–25.65), periodontal disease (17.78%, 95% CI: 16.55–19.01), overgrown nail(s) (11.61%, 95% CI: 10.58–12.64), otitis externa (11.18%, 95% CI: 10.17–12.19) and anal sac impaction (10.59%, 95% CI 9.60-11.58). Once disorders were grouped by pathology, the most common group-level disorders were obesity (24.27%, 95% CI: 22.89–25.65), dental disorders (21.48%, 95% CI: 20.16–22.80), ear disorders (13.62%, 95% CI: 12.52–14.72), claw/nail disorders (13.14%, 95% CI: 12.06–14.22) and anal sac disorders (11.10%, 95% CI: 10.09–12.11). The median age at death was 11.28 years (IQR 9.32–13.08) for 322 deaths recorded during the study period. The most common causes of death at group level were neoplasia (19.26%, 95% CI: 14.76–23.75), mass (13.18%, 95% CI: 9.32–17.03), poor quality of life (12.84%, 95% CI: 9.03–16.65), and brain disorders (6.76%, 95% CI: 3.90–9.62). Conclusions Their disorder profile suggests the Beagle breed should not be considered to have an extreme conformation. Owners and veterinary teams should put special emphasis on care related to bodyweight control and dental hygiene in Beagles. Their median age at death of 11.70 years suggests reasonable overall health but neoplasia is a common biomedical cause of death in Beagles.

Background Domestic rabbit breeds vary substantially from the wild rabbit body type. However, little is known about how the conformation of pet rabbits influences their health. Methods Data were extracted from VetCompass anonymised clinical records of rabbits under UK primary veterinary care during 2019. Results The study included 162,107 rabbits. Based on 88,693 rabbits with relevant breed information recorded, skull shape was classified as brachycephalic (79.69%), mesaticephalic (16.80%) and dolichocephalic (3.51%). Based on 83,821 rabbits with relevant breed information recorded, ear carriage was classified as lop‐eared (57.05%) and erect‐eared (42.95%). From a random sample of 3933 rabbits, the most prevalent disorders recorded overall were overgrown nail(s) (28.19%), overgrown molar(s) (14.90%) and obesity (8.82%). Compared to those with a mesaticephalic skull shape, brachycephalic rabbits had lower odds of obesity, anorexia and gastrointestinal stasis and higher odds of perineal faecal impaction, tear duct abnormality and haircoat disorder. Compared to erect‐eared rabbits, lop‐eared rabbits had higher odds of perineal faecal impaction and tear duct abnormality. Limitation A large proportion of records with incomplete breed information hindered full analysis for breed‐related and conformation‐related attributes. Conclusion Limited evidence for major links between skull shape or ear carriage conformations and overall disorder risk suggests that factors such as husbandry or even just living life as a domesticated species may be bigger drivers of common health issues in pet rabbits in the UK.

There is growing evidence supporting clinically important associations between age at neutering in bitches and subsequent urinary incontinence (UI), although much of this evidence to date is considered weak. Target trial emulation is an innovative approach in causal inference that has gained substantial attention in recent years, aiming to simulate a hypothetical randomised controlled trial by leveraging observational data. Using anonymised veterinary clinical data from the VetCompass Programme, this study applied the target trial emulation framework to determine whether later-age neutering (≥ 7 to ≤ 18 months) causes decreased odds of early-onset UI (diagnosed < 8.5 years) compared to early-age neutering (3 to < 7 months). The study included bitches in the VetCompass database born from January 1, 2010, to December 31, 2012, and neutered between 3 and 18 months old. Bitches were retrospectively confirmed from the electronic health records as neutered early or later. The primary outcome was a diagnosis of early-onset UI. Informed from a directed acyclic graph, data on the following covariates were extracted: breed, insurance status, co-morbidities and veterinary group. Inverse probability of treatment weighting was used to adjust for confounding, with inverse probability of censoring weighting accounting for censored bitches. The emulated trial included 612 early-age neutered bitches and 888 later-age neutered bitches. A pooled logistic regression outcome model identified bitches neutered later at 0.80 times the odds (95% CI 0.54 to 0.97) of early-onset UI compared with bitches neutered early. The findings show that later-age neutering causes reduced odds of early-onset UI diagnosis compared with early-age neutering. Decision-making on the age of neutering should be carefully considered, with preference given to delaying neutering until after 7 months of age unless other major reasons justify earlier surgery. The study is one of the first to demonstrate successful application of the target trial framework to veterinary observational data.