David Adlersberg's research while affiliated with Mount Sinai Hospital and other places

Publications (76)

Article
Histochemical and chemical studies of the acid mucopolysaccharide content of the aorta were made in rabbits fed cholesterol for up to seven months. Colloidal iron staining suggested an increase in acid mucopolysaccharide content of the aortas with mild atheromatous lesions but not when severe lesions were present. Chemical determination, however, r...
Article
The low incidence of atherosclerosis in premenopausal women and the effects of gonadal extracts on serum lipids indicate the desirability of further clinical and biochemical studies. Ethinyl estradiol was administered to 12 persons with idiopathic hyperlipemia or idiopathic hypercholesteremia. Medication was given for an average period of 16 months...
Article
Serum phospholipid levels were determined in 1,067 healthy persons aged 2 to 77 years. Phospholipid levels increased with age but in a different way for each of the sexes. The age-sex changes of serum phospholipids were similar to those observed for serum cholesterol. Correlation coefficients in members of 156 families indicated that the genetic fa...
Article
Serum cholesterol levels of 1,236 healthy persons, including 775 members of 201 families, were analyzed in the investigation of the genetic control of serum cholesterol. It was concluded that there is an important genetic component in the determination of this level in healthy persons, that the gene is probably not sex-linked, and that environmenta...
Article
Studies of serum proteins, lipoproteins, and "glycoproteins" by paper electrophoresis have been performed in 10 patients with idiopathic hyperlipemia and 8 patients with idiopathic hypercholesteremia diagnosed by established clinical criteria and chemical analysis of serum lipids. Idiopathic hyperlipemia was characterized by an increase in alpha-2...
Article
Starch electrophoresis was employed for the study of the lipoprotein patterns in inborn errors of lipid metabolism. Idiopathic hyperlipemia was characterized by marked increases of cholesterol and phospholipid in the alpha-2-lipoprotein fraction of the serum whereas idiopathic hypercholesteremia showed an increase of these lipids in the beta-lipopr...
Article
• Chemical determinations of serum cholesterol and phospholipid values were made in 1,200 specimens of blood obtained from healthy males and females between the ages of 2 and 77 years. The sample represented a particular geographic group with certain sociological characteristics. In 38 men of the 28 to 32 year age group, the average serum cholester...
Article
Previous investigations have established the normal lipid partition and lipoprotein profile in man, dog and rabbit (1, 2). Elevation of serum lipid fractions has been reported in patients treated with prolonged and large dosages of cortisone (3–5), and in rabbits and dogs receiving cortisone acetate or hydrocortisone acetate (6, 7). Hypercholestere...
Article
OVER 100 years ago Virchow described the development of endarteritis deformans, a term used by him for atherosclerosis, and observed the alteration of the tissue ground substance in the evolution of this condition. Research in this field has been greatly influenced by the observation that feeding cholesterol resulted in the production of severe ath...
Article
Cortisone has a retarding effect on atherogenesis in cholesterol-fed rabbits, despite higher plasma cholesterol levels. This effect of cortisone is prevented by administration of hyaluronidase. The latter intensifies atherosclerosis and deposition of cholesterol in the liver.
Article
Cortisone administration to dogs is followed by a selective rise in plasma alpha-2 globulin and fall in beta globulin which is independent of any associated lipid changes; this shift in globulin distribution has not been observed in humans or rabbits receiving cortisone.
Article
The chemical analysis of the lipids in serum or plasma yields data for total lipids, phosphatides, total and esterified cholesterol, and by subtraction, for neutral fat. Zone electrophoresis, for which experimental details are given, shows the distribution of the serum lipids between α-globulin, -globulin, and a fraction which does not move in the...
Article
The serum cholesterol of eighty-six patients with aortic stenosis, forty-three men and forty-three women, and of sixty-seven patients with chronic rheumatic valvular disease, twenty-two men and forty-five women, was determined. Using Keys' standards, 48.8 per cent of the females and 18.6 per cent of the males with aortic stenosis were hypercholeste...
Article
The serum cholesterol of eighty-six patients with aortic stenosis, forty-three men and forty-three women, and of sixty-seven patients with chronic rheumatic valvular disease, twenty-two men and forty-five women, was determined. Using Keys' standards, 48.8 per cent of the females and 18.6 per cent of the males with aortic stenosis were hypercholeste...
Article
Hypercholesteremia appears to be a common denominator for most patients with early coronary atherosclerosis. The frequency of the occurrence of this disorder and its possible genetic relationship become, therefore, important points in any studies designed to further our knowledge of coronary artery disease, particularly that occurring in the younge...
Article
In the field of disturbances of lipid metabolism certain inborn errors have long been known. The genetic mechanisms involved in these disorders are summarized, with special emphasis on primary cholesterol lipidosis (xanthomatosis). Genetic analysis supports the concept that this disturbance of cholesterol metabolism is inherited as an (incomplete)...
Article
This investigation indicates that cortisone produced well-characterized changes of serum lipids in man. The effects of ACTH on the serum lipids were less pronounced.
Article
THE LIPIDS OF BLOOD SERUM may be classified as follows: triglycerides, phosphatides (predominantly with a P/N ratio of 1:1), and cholesterol, in the free and in the esterifled form. There are in addition small amounts of free fatty acids, acetal phosphatides, phosphatidic acids, carotenoids, and lipid hormones and vitamins, which we shall, however,...
Article
1. A Carotene Tolerance Test employing 120 mg. of crystalline carotene in a vehicle of 24 gm. of butter was elaborated for the study of carotene metabolism in man. A test dose of 60 mg. carotene in 12 gm. of butter proved to be too small, while the higher dose of 180 mg. carotene in 36 gm. of butter offered no additional advantage. 2. The elevatio...

Citations

... Several hypotheses are available to account for lipid in the arterial wall: (1) in situ synthesis, 19 ' 25 (2) imbibition, either by passive filtration 32 or active pinocytosis, 9 and (3) fixation through chemical action of the connective tissue mucopolysaccharides. 20 The in situ synthesis of lipid in many respects reflects the universality of lipids in all living cells. The other 2 theories of lipidosis in the arterial wall are not incompatible with a unified concept. ...
... Much experimental and clinical research from the 1950s has shown relations between increased serum phospholipids and atherosclerosis, and thus cardiovascular disease 17,30,31 . The considerable presence of phospholipids in atheromatous plaques and their synthesis in the arterial wall have also been shown 32 . ...
... The canonical anterograde lipid-absorptive pathways within enterocytes have been extensively studied given their obvious physiologic importance. However, as early as the 1950s, evidence of reverse intestinal lipid trafficking -that is, transcellular efflux of cholesterol from the circulation into the intestinal lumenbegan to emerge [8][9][10][11][12]. The colocalization of cholesterol and triglycerides within lipoproteins naturally raises the question of a parallel pathway for fats -and, in fact, there is general agreement that intestinal epithelial cells take up circulating fat across their basolateral membrane. ...
... Hypercholesterolemia and hypertriglyceridemia, as predisposing factors for atherosclerosis and coronary heart disease (CHD), are of concern and have been intensively studied (Adlersberg, 1951;Albrink et al., 1961;Brown et al., 1965;Kannel et al., 1971;Epstein and Ostrander, 1971). Several workers have also investigated the associations of plasma cholesterol and lipoprotein concentrations with atherosclerosis. ...
... in human beings is well known (Bookman et al., 1953). Steroid elevates blood glucose level by increasing gluconeogenesis and inhibiting glucose uptake into muscles. ...
... Factors aggregating in case-families vs. comparison-families were identified as potential coronary heart disease (CHD) risk factors, including reports of increased total cholesterol in siblings of CHD patients. [2][3][4] Later studies reported elevated LDL-cholesterol in offspring of patients with premature myocardial infarction. 5-8 Community-based studies of unselected families found ...
... Moreover, in older subjects clearance of chylomicrons to fasted levels took nearly 24 h (11). In 1953, Herzstein et al. similarly found that clearance of total serum lipids was delayed in older (ages 51-71) compared to younger (ages 17-34) subjects after a fat-loaded meal (8). A more recent study by Vinagre et al. suggested that the delayed triglyceride clearance in older subjects is due, at least in part, to delayed clearance of remnant particles in the liver (12). ...
... 12 However, the first cases of AS in FH patients were published in the 1940s and 50s. [13][14][15][16] In the pre-statin era, supravalvular aortic stenosis (SVAS) was described as a feature in HoFH. The aim of the present study was to provide a systematic review of AS in HoFH patients and to examine the changing presentation of this condition over time. ...
... A normal volunteer maintained on a vitamin-C-deficient diet did not develop scurvy until he had been on this diet for 161 days (Crandon, Lund, and Dill, 1940). In a similar experiment performed upon himself in the eighteenth century, William Stark developed scurvy only after two months (Drummond and Wilbraham, 1935 (Wang, Janowitz, and Adlersberg, 1956;Schaffner and Scherbel, 1955) that the disease may be favourably influenced by steroids in its early stages. They reported on patients who showed improvement on corticoids over a follow-up period of 20 and 10 months respectively. ...
... The diagnosis depends upon (1) the finding of clear fasting serum, with raised concentrations of ,B-lipoprotein and cholesterol, and normal or only slightly raised levels of triglyceride; (2) the exclusion of other causes of hyper-P-lipoproteinaemia such as hypothyroidism and obstructive jaundice; and (3) the demonstration of hyper-P-lipoproteinaemia in other members of the family. The earliest age at which the diagnosis can be established with certainty is not known; in two children the finding of a high cholesterol level in umbilical cord blood has subsequently enabled the diagnosis to be made (Kaplan et al., 1957; Wolff, 1967a ...