Danielle Herbert’s research while affiliated with University of Edinburgh and other places

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Publications (1)


The mental health impact of perinatal loss: A systematic review and meta-analysis
  • Literature Review
  • Full-text available

October 2021

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475 Reads

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58 Citations

Journal of Affective Disorders

Danielle Herbert

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Maria Pietrusińska

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Perinatal loss can pose a significant risk to maternal mental health. There is limited data on the strength of association between perinatal loss and subsequent common mental health disorders (CMHD) such as anxiety, depression and post-traumatic symptoms (PTS). A systematic review and meta-analysis identified studies with control groups, published between January 1995 and March 2020 reporting validated mental health outcomes following perinatal loss. We identified 29 studies from 17 countries, representing a perinatal loss sample (n=31,072) and a control group of women not experiencing loss (n = 1,261,517). We compared the likelihood of increased CMHD in both groups. Random-effects modelling on suggested that compared to controls, perinatal loss was associated with increased risk of depressive (RR = 2.14, 95% CI = 1.73-2.66, p < .001, k = 22) and anxiety disorders (RR = 1.75, 95% CI = 1.27-2.42, p < .001, k = 9). Compared to controls, Perinatal loss was also associated with increased depression (SMD = 0.34, 95% CI = 0.20-0.48, p < .001, k =12) and anxiety scores (SMD = 0.35, 95% CI = 0.12-0.58, p < .003, k = 10). There were no significant effects for post-traumatic stress (PTS) outcomes (k=3). Our findings confirm that anxiety and depression levels following perinatal loss are significantly elevated compared to “no loss” controls (live-births, non pregnant from community, or difficult live births). Elevated depression and anxiety rates were also reported for those who experienced loss during later stages of pregnancy. Assessing mental health following loss is a maternal health priority.

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Citations (1)


... Pregnancy is a sensitive period in a woman's life when psychological distress can have negative consequences for the mother and fetus. Many studies have shown that prolonged and intensified symptoms of anxiety and depression increase the risk of miscarriage, premature birth, low APGAR score, postpartum depression, and increased incidence of prenatal infections [1][2][3]. Mothers who have experienced high levels of stress during pregnancy give birth to children who are at increased risk of developing mental illnesses later in life [4,5]. Additionally, Sabbagh et al. showed in their retrospective cohort study that stressful life events during pregnancy, along with an family history of congenital disabilities, may be the risk factor for the development of non-syndromic orofacial clefts [6]. ...

Reference:

The Serbian version of the Pandemic-Related Pregnancy Stress Scale (PREPS-SRB)–A validation study
The mental health impact of perinatal loss: A systematic review and meta-analysis

Journal of Affective Disorders