Daniela Seixas's research while affiliated with University of Coimbra and other places

... For example, the Clarke score relies on experiences with severe hypoglycemia for scoring and IAH classification. 20 However, experiences with severe hypoglycemia may not be a good predictor of IAH given the widespread use of CGM, which reduces severe hypoglycemia events in individuals with IAH despite residual defects in glucose counterregulation. 21 Indeed, as reported by Sepúlveda et al, 20 with the increasing use of CGM technologies containing predictive and threshold alerts and alarms for detecting hypoglycemia, the Clarke score may not distinguish "technologic awareness" from "endogenous awareness" of hypoglycemia. ...

... 17 Harmonization initiatives have provided consensus reports for MRI in MS, moving toward standardization and dissemination of protocols that facilitate clinical translation and comparison of data across sites. [18][19][20][21][22] T 2 -weighted imaging is well established and frequently used for identification of white matter (WM) lesions, which have a hyperintense appearance. 5,23 Although being an important diagnostic criterion for MS, 24 the WM lesion load correlates only weakly with clinical disability because of its lack of specificity for lesion severity and the underlying pathophysiology. ...

... Accordingly, task based or resting-state functional studies have been performed to examine language and auditory sub-regions and their inter connections with other functional circuits (16)(17)(18)(19). The relation between functional connectivity (FC) and language (20,21) and auditory (22)(23)(24)(25) performance has been demonstrated using resting-state fMRI (rs-fMRI). Xiang et al. (26) showed that the topology of FC in 6 frontal sub-regions of perisylvian language network during rest, is consistent with the topology of language network of the brain. ...

... Additionally, due to the higher SNR, the temporal reliability of mapping is also improved, lending the technique a broader clinical range. For example, RS-fMRI at 7 T has been shown to enhance the temporal reliability of sensorimotor and language network detection in preoperative planning [45] and for mapping habenula restingstate networks involved in anxiety and addiction disorders [46]. ...

... Memory and executive function deficits seem to be more frequent as long as the disease progresses, although information processing speed tends to appear early and progress slowly (Brochet and Ruet, 2019). There is a higher prevalence of cognitive impairment in progressive forms of MS than in relapsing forms, consistent with pathological findings that highlight the major involvement of the gray matter in these phenotypes (Gouveia et al., 2017). ...

... The group of basal nuclei has certain functional features: The caudate nucleus is involved in the development of behavioral reactions, both as a part of the reward system and attention holding mechanism. Functional and structural disorders were described in the caudate and accessory nuclei in patients with multiple sclerosis and chronic pain syndrome (Seixas et al., 2016). These structures form close connections with the prefrontal cortex and participate in the development of behavioral reactions, planning of cognitive and motor acts, supporting the decision-making system (O'Doherty, 2004). ...

... Private label purchasers prioritized cheap pricing during purchase, while value-conscious shoppers preferred lower-priced options (Palazon and Delgado, 2009;Diallo and Siqueira, 2017;Steenkamp et al., 2010;Cho et al., 2015). As per Santos et al., (2016) cheap PLBs were more persuasive than expensive national brands. Price consciousness (PC) was linked to price sensitivity and affordability. ...

... Recent results have highlighted the importance of white matter structural disconnections in the disruption of functional connectivity 53 , and this disruption has been linked to behavioural and cognitive dysfunction 54,55 . Therefore, being able to identify these RSN white matter "highways" would propel our understanding of disconnection symptoms, improve recovery prognostics, and inform preoperative brain surgery planning 56 . To facilitate these efforts, we released the WhiteRest tool (as a module of the Functionnectome) that quantifies the presence of RSNs in a specific region of the brain's white matter. ...

... In this respect, neuropathic pain, which usually manifests as electric shocks, unpleasant perception of intense cold, and feelings of pressure or constriction, can occur at almost any site; it is generally chronic and, as such, can be extremely disabling. 3 Pain is one of the most common complaints of persons with multiple sclerosis (PwMS), 4 an autoimmune disease characterised by inflammation, selective demyelination and gliosis of central nervous system white matter. In particular, PwMS patients describe their pain as often widespread, chronic STRENGTHS AND LIMITATIONS OF THIS STUDY ⇒ Our novel study design will allow the characterisation of the physiological response to pain and its exploitation to assess the pain experience objectively. ...

... e most significant deficit in neurosurgical care exists in Southeast Asia, where nearly 2.5 million cases go undiagnosed. [2,4] In West Africa, just 84 MRI units serve a combined population of more than 300 million people. [11] Lack of equipment, such as an MRI machine, contributes to the inadequacy of diagnosis and essential neurosurgical care, which is why neurosurgical care in LMICs remains a luxury. ...