Daniel Tranel's research while affiliated with University of Iowa and other places

Publications (415)

Article
Social network size has been associated with complex socio-cognitive processes (e.g., memory, perspective taking). Supporting this idea, recent neuroimaging studies in healthy adults have reported a relationship between social network size and brain volumes in regions related to memory and social cognition (e.g., hippocampus, amygdala). Lesion-defi...
Preprint
Inhibitory control is one of the most important control functions in the human brain. Much of our understanding of its neural basis comes from seminal work showing that lesions to the right inferior frontal cortex (rIFC) increase stop-signal reaction time (SSRT), a latent variable that expresses the speed of inhibitory control. However, recent work...
Article
Objectives: This study investigated academic skills outcomes after brain injury and identified the influence of age and injury factors across the lifespan. Method: Our sample included 651 participants with focal brain lesions. Math, reading, and spelling data from the Wide Range Achievement Test (WRAT) were used as the academic skills outcomes....
Article
This research aimed to broaden understanding of learning verbal material in participants with left- and right-sided mesial temporal lobe epilepsy (MTLE). We modeled word list-learning to determine how anterior temporal lobe resection affects verbal learning. Verbal learning (across trials) was assessed using the first five trials of the Rey Auditor...
Article
Traumatic brain injury (TBI) and stroke both have the potential to cause significant damage to the brain, with resultant neuropsychological impairments. How these different mechanisms of injury influence cognitive and behavioral changes associated with brain damage, however, is not well understood. Moreover, previous research directly comparing TBI...
Chapter
The study under discussion sought to investigate the hemispheric laterality of musical emotions: Is one hemisphere of the brain preferentially involved in recognizing emotions in music? The authors took a neuropsychological approach to answer this question by studying emotional judgments of music in people with brain damage to either hemisphere. Th...
Article
Clinicians and scientists alike have long sought to predict the course and severity of chronic post-stroke cognitive and motor outcomes, as the ability to do so would inform treatment and rehabilitation strategies. However, it remains difficult to make accurate predictions about chronic post-stroke outcomes due, in large part, to high inter-individ...
Article
“Frontal lobe syndrome” is a term often used to describe a diverse array of personality disturbances following frontal lobe damage. This study’s guiding premise was that greater neuroanatomical specificity could be achieved by evaluating specific types of personality disturbances following acquired frontal lobe lesions. We hypothesized that three a...
Chapter
Trust is essential for establishing and maintaining cooperative behaviors between individuals and institutions in a wide variety of social, economic, and political contexts. This book explores trust through the lens of neurobiology, focusing on empirical, methodological, and theoretical aspects. Written by a distinguished group of researchers from...
Article
BACKGROUND Chiari Malformation Type I (CM-I) is defined as cerebellar tonsil displacement more than 5 mm below the foramen magnum. This displacement can alter cerebrospinal fluid flow at the cervicomedullary junction resulting in Valsalva-induced headaches and syringomyelia and compress the brainstem resulting in bulbar symptoms. However, little is...
Article
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Hubs in the human brain support behaviors that arise from brain network interactions. Previous studies have identified hub regions in the human thalamus that are connected with multiple functional networks. However, the behavioral significance of thalamic hubs has yet to be established. Our framework predicts that thalamic subregions with strong hu...
Article
Little is known about the role of declarative memory in the ongoing perception of one’s personality. Seven individuals who developed a rare and severe type of anterograde amnesia following damage to their medial temporal lobes were identified from our neurological patient registry. We examined the stability of their personality ratings on the Big F...
Article
Objective Post operative cognitive dysfunction (POCD) has been widely observed after major surgery, particularly in elderly patients with general anesthesia (GA). However, a specific unanswered question is whether different approaches to anesthetic managements are associated with different cognitive outcomes after endovascular treatments for unrupt...
Article
Although lesion-deficit case studies are foundational in cognitive neuroscience, published papers presenting single lesion cases are declining. In this review, we argue that there is a valuable place for single-case lesion-deficit research, especially when combined with functional neuroimaging methods, such as functional magnetic resonance imaging...
Conference Paper
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Introduction Inflammation is an important mechanism of ischemic brain injury. It is characterized by inflammatory mediators and molecules including cytokines and interleukins. This inflammatory mechanism and its interaction among these Ischemic Stroke (IS) patients is still ambiguous. The aim of this investigation is to elucidate and characterize t...
Article
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Social cognition and emotion are ubiquitous human processes that recruit a reliable set of brain networks in healthy individuals. These brain networks typically comprise midline (e.g., medial prefrontal cortex) as well as lateral regions of the brain including homotopic regions in both hemispheres (e.g., left and right temporo-parietal junction). Y...
Article
Hubs are highly connected brain regions important for coordinating processing in brain networks. It is unclear, however, which measures of network “hubness” are most useful in identifying brain regions critical to human cognition. We tested how closely two measures of hubness—edge density and participation coefficient, derived from white and gray m...
Preprint
Hubs in the human brain support behaviors that arise from brain network interactions. Previous studies have identified hub regions in the human thalamus that are connected with multiple functional networks. However, the behavioral significance of thalamic hubs has yet to be established. Our framework predicts that thalamic subregions with strong hu...
Article
Introduction: Acute Ischemic Stroke (AIS) is one of the leading causes of disability and death in US. Although Endovascular Therapy (EVT) remains the mainstay therapy during acute phase for large vessel occlusions (LVOs), functional outcome varies among the treated patients. This ischemic injury results in an inflammatory response which plays an im...
Article
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The amygdala is a subcortical structure implicated in both the expression of conditioned fear and social fear recognition. Social fear recognition deficits following amygdala lesions are often interpreted as reflecting perceptual deficits, or the amygdala's role in coordinating responses to threats. But these explanations fail to capture why amygda...
Article
Full-text available
General cognitive ability – or general intelligence (g) – is central to cognitive science, yet the processes that constitute it remain unknown, in good part because most prior work has relied on correlational methods. Large-scale behavioral and neuroanatomical data from neurological patients with focal brain lesions can be leveraged to advance our...
Article
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There is controversy regarding the unique contributions of the right and left hemispheres for human cognition. The right hemisphere is thought to play an important role in “nonverbal” cognitive abilities, such as visuospatial processing. ¹ However, the necessity of the right hemisphere for other aspects of cognition has been challenged by the relat...
Article
Background: Research has indicated that individuals with Alzheimer's-type dementia (AD) can experience prolonged emotions, even when they cannot recall the eliciting event. Less is known about whether music can modify the emotional state of individuals with AD and whether emotions evoked by music linger in the absence of a declarative memory for t...
Article
The human thalamus has been suggested to be involved in executive function, based on animal studies and correlational evidence from functional neuroimaging in humans. Human lesion studies, examining behavioral deficits associated with focal brain injuries, can directly test the necessity of the human thalamus for executive function. The goal of our...
Preprint
Full-text available
The belief-default model contends that believing is inexorable during comprehension, and falsification is a subsequent, secondary process. By contrast, the Cartesian belief-fixation model argues that naïve propositions may be mentally represented without a truth or falsity stance. In the present research, data from four studies help adjudicate beli...
Article
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Defense mechanisms are mental functions which facilitate coping when real or imagined events challenge personal wishes, needs, and feelings. Whether defense mechanisms have a specific neural basis is unknown. The present research tested the hypothesis that interhemispheric integration plays a critical role in defense mechanism development, by study...
Article
Functional neuroimaging research has consistently associated brain structures within the default mode network (DMN) and frontoparietal network (FPN) with mind‐wandering. Targeted lesion research has documented impairments in mind‐wandering after damage to the medial prefrontal cortex (mPFC) and hippocampal regions associated with the DMN. However,...
Article
Full-text available
For the hemispheric laterality of emotion processing in the brain, two competing hypotheses are currently still debated. The first hypothesis suggests a greater involvement of the right hemisphere in emotion perception whereas the second hypothesis suggests different involvements of each hemisphere as a function of the valence of the emotion. These...
Article
Full-text available
The links between emotions, bio-regulatory processes, and economic decision-making are well-established in the context of age-related changes in fluid, real-time, decision competency. The objective of the research reported here is to assess the relative contributions, interactions, and impacts of affective and cognitive intelligence in economic, va...
Article
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Denoising fMRI data requires assessment of frame-to-frame head motion and removal of the biases motion introduces. This is usually done through analysis of the parameters calculated during retrospective head motion correction (i.e., ‘motion’ parameters). However, it is increasingly recognized that respiration introduces factitious head motion via p...
Article
Background: Seizure-induced inhibition of respiration plays a critical role in sudden unexpected death in epilepsy (SUDEP). However, the mechanisms underlying seizure-induced central apnea in pediatric epilepsy are unknown. Methods: We studied eight pediatric patients with intractable epilepsy undergoing intracranial electroencephalography (iEEG...
Preprint
Full-text available
Denoising fMRI data requires assessment of frame-to-frame head motion and removal of the biases motion introduces. This is usually done through analysis of the parameters calculated during retrospective head motion correction (i.e., ‘motion’ parameters). However, it is increasingly recognized that respiration introduces factitious head motion via p...
Article
Full-text available
Background: Some patients experience long-term declines in quality of life following meningioma resection, but associated factors are not well understood. Objective: To investigate whether long-term declines in quality of life (specifically impaired adaptive functioning) after meningioma resection are associated with specific personality disturb...
Article
Meditation is commonly assumed to be associated with enhanced interoceptive accuracy. We previously found that experienced meditators did not exhibit a greater ability than nonmeditators to detect heartbeat sensations at rest, despite the meditators' reported subjective ratings of higher accuracy and lower difficulty. Here, attempting to overcome p...
Chapter
Behavioral neurology encompasses a variety of diseases and disorders of higher brain functions, related to focal or diffuse cortical and subcortical brain disease. We use “higher” to refer to the fact that the domain of behavioral neurology covers the most complex and advanced aspects of human cognition and behavior, including functions such as mem...
Article
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The human impulse to punish those who have unjustly harmed others (i.e., third-party punishment) is critical for stable, cooperative societies. Punishment selection is influenced by both harm outcome and the intent of the moral agent (i.e., the offender's knowledge of wrongdoing and desire that the prohibited consequence occur). We allocate severe...
Article
OBJECTIVE Revascularization of a symptomatic, medically refractory, cervical chronically occluded internal carotid artery (COICA) using endovascular techniques (ETs) has surfaced as a viable alternative to extracranial-intracranial bypass. The authors aimed to assess the safety, success, and neurocognitive outcomes of recanalization of COICA using...
Article
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The role of the frontal lobes in cognition and behavior has long been enigmatic. Over the past decade, computational models have provided a powerful approach to understanding cognition and decision-making. Here, we used a model-based approach to analyze data from a classical task used to assess frontal lobe function, the Wisconsin Card Sorting Test...
Chapter
The frontal lobes contain a complex set of diverse anatomic regions that form multiple distinct, complex networks with cortical and subcortical regions. Damage to these cortical-subcortical networks can have dramatic behavioral consequences, ranging from apathy to impairments in executive functioning. This chapter provides a brief overview of the c...
Article
Familiar music contains salient cues that often evoke vivid and emotionally powerful autobiographical memories. Prior work suggests that memories evoked by music may be different from memories evoked by other cues (e.g., words and visual images). For example, music-evoked autobiographical memories (MEAMs) have been shown to contain a greater propor...
Article
Objective: To determine which patient, provider and practice-related characteristics are associated with increased likelihood of driving-related recommendations following a neuropsychological evaluation. Method: A total of 309 clinical neuropsychologists completed a survey evaluating the frequency with which they made various driving-related recomm...
Article
Prior research has implicated the left temporal pole (LTP) as a critical region for naming semantically unique items, including famous faces, landmarks, and musical melodies. Most studies have used a confrontation naming paradigm, where a participant is presented with a stimulus and asked to retrieve its name. We have proposed previously that the L...
Article
Full-text available
Introduction Caregivers of individuals with dementia are at heightened risk for stress-related mental and physical illnesses, and this problem is growing. There is a critical need to develop effective interventions for caregivers. This study tested whether a 2-day intervention improved psychological health in caregivers of individuals with dementia...
Article
Studies of individuals with focal brain damage have long been used to expand understanding of the neural basis of psychopathology. However, most previous studies were conducted using small sample sizes and relatively coarse methods for measuring psychopathology or mapping brain-behavior relationships. Here, we examined the factor structure and neur...
Article
Objective: Episodic future thinking is the ability to mentally project oneself into the future. This construct has been explored extensively in cognitive neuroscience and may be relevant for adaptive functioning. However, it has not been determined whether the measurement of episodic future thinking might be valuable in a clinical neuropsychologic...
Article
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Neurological patients with damage to the ventromedial prefrontal cortex (vmPFC) are reported to display reduced empathy toward others in their daily lives in clinical case studies. However, the empathic behavior of patients with damage to the vmPFC has not been measured experimentally in response to an empathy-eliciting event. This is important bec...
Article
Conceptualizations of the nature of acquired personality disturbances after brain damage, especially to prefrontal cortex, have progressed from clinical observations of a large, disparate set of disturbances to theories concerning neuroanatomically-based subgroups with prefrontal damage. However, hypothesized subtypes have not yet been studied syst...
Article
Objective: To identify types of recommendations that neuropsychologists most frequently give to patients, and determine which specific recommendations are most and least consistently given to patients across and within different diagnostic populations. Method: A total of 309 clinical neuropsychologists completed a survey evaluating the frequency...
Article
The ability to flexibly combine existing knowledge in response to novel circumstances is highly adaptive. However, the neural correlates of flexible associative inference are not well characterized. Laboratory tests of associative inference have measured memory for overlapping pairs of studied items (e.g., AB, BC) and for nonstudied pairs with comm...
Article
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Objective: A well-documented effect of focal ventromedial prefrontal cortex (vmPFC) damage is a deficit in real-world decision making. An important aspect of this deficit may be a deficiency in "internal consistency" during social decision making-that is, impaired congruence between expressed preferences versus actual behavioral choices. An exampl...
Article
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Implicit moral evaluations-spontaneous, unintentional assessments of the moral status of actions or persons-play a pivotal role in supporting moral behavior, yet little research has attempted to model variability in these moral evaluations across healthy and clinical populations. Prior research reveals that the ventromedial prefrontal cortex (vmPFC...
Article
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All behavior is proximally caused by the brain, but the neural causes of most complex behaviors are still not understood. Much of our ignorance stems from the fact that complex behavior depends on distributed neural control. Unlike a reflex, where the arc from sensation to action can be traced through a few synapses, most volitional behavior involv...
Article
Background: Previous work has investigated extensively the neuroanatomical correlates of lexical retrieval of words for concrete entities. Musical entities, such as musical instruments, are often included in studies of category-specific naming deficits but have rarely been the focus of such work. Aims: This article reviews a program of research inv...
Article
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Objective: The objective of this study was to determine whether preoperative [18F]fludeoxyglucose (FDG)-positron emission tomography (PET) asymmetry in temporal lobe metabolism predicts neuropsychological and seizure outcomes after temporal lobectomy (TL). Methods: An archival sample of 47 adults with unilateral temporal lobe epilepsy who underw...
Article
Research on changes in personality and behavior following brain damage has focused largely on negative outcomes, such as increased irritability, moodiness, and social inappropriateness. However, clinical observations suggest that some patients may actually show positive personality and behavioral changes following a neurological event. In the curre...
Article
Objective: We highlight the past 25 years of cognitive neuroscience and neuropsychology, focusing on the impact to the field of the introduction in 1992 of functional MRI (fMRI). Method: We reviewed the past 25 years of literature in cognitive neuroscience and neuropsychology, focusing on the relation and interplay of fMRI studies and studies ut...
Article
Temporal lobe epilepsy (TLE) can be associated with a marked impairment of autobiographical memory. This is occasionally its presenting feature. We describe two individuals with severe epilepsy-associated autobiographical memory loss. Both MB and PT were reassured initially that their memory was intact on the basis of standard neuropsychological te...
Article
See Manohar and Akam (doi:10.1093/brain/awx119) for a scientific commentary on this article. Neuroimaging studies suggest that the human ventromedial prefrontal cortex is a key region for goal-directed behaviour. However, it remains unclear whether the ventromedial prefrontal cortex is necessary for such behaviour. Here we used a canonical test fro...
Preprint
Functional connectivity, as measured by resting-state fMRI, has proven a powerful method for studying brain systems in the context of behavior, development, and disease states. However, the relationship of functional connectivity to structural connectivity remains unclear. If functional connectivity relies on structural connectivity, then anatomica...
Article
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A growing body of literature demonstrates that racial group membership can influence neural responses, e.g., when individuals perceive or interact with persons of another race. However, little attention has been paid to social class, a factor that interacts with racial inequalities in American society. We extend previous literature on race-related...
Article
Objective: Psychological adjustment following surgery for epilepsy has been assessed primarily with self-report measures. In the current work, we investigated pre- to postoperative changes in various dimensions of personality and behavior from the perspective of a well-known family member or friend for 27 patients operated on for medically intract...
Article
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Dating back to the case of Phineas Gage, decades of neuropsychological research have shown that the ventromedial prefrontal cortex (vmPFC) is crucial to both real-world social functioning and abstract decision making in the laboratory (see, e.g., Stuss et al., 1983; Bechara et al., 1994; Damasio et al., 1994). Previous research has shown that the r...
Article
Acute psychological stress affects each of us in our daily lives and is increasingly a topic of discussion for its role in mental illness, aging, cognition, and overall health. A better understanding of how such stress affects the body and mind could contribute to the development of more effective clinical interventions and prevention practices. Ov...
Article
People listen to music because it is pleasurable. However, there are individual differences in the reward value of music. At the extreme low end of this continuum, individuals who derive no pleasure from music are said to have ‘musical anhedonia.’ Cases of acquired musical anhedonia following focal brain damage are rare, with only a handful having...