Danai Katsanevaki's research while affiliated with The University of Edinburgh and other places

Publications (3)

Article
Full-text available
Information processing is energetically expensive. In the mammalian brain, it is unclear how information coding and energy use are regulated during food scarcity. Using whole-cell recordings and two-photon imaging in layer 2/3 mouse visual cortex, we found that food restriction reduced AMPA receptor conductance, reducing synaptic ATP use by 29%. Ne...
Article
Wang et al. show that normal development of mouse binocular vision involves the selective apoptosis of chandelier interneurons in binocular visual cortex. This process is driven by retinal and transcallosal activity before eye-opening and may promote subsequent selective wiring of binocular connections.
Article
Full-text available
The potential for neuronal representations of external stimuli to be modified by previous experience is critical for efficient sensory processing and improved behavioral outcomes. To investigate how repeated exposure to a visual stimulus affects its representation in mouse primary visual cortex (V1), we performed two-photon calcium imaging of layer...

Citations

... For example, if neurons are optimized for the best compromise between function and energy efficiency, what happens if they face perturbations such as scarcity of energy resources? Interestingly, a recent study [113] has shown that in animals with food restriction, layer 2/3 pyramidal cells (L2/3 PCs) in visual cortex increase their energy efficiency (by weakening their input synapses) but reduce their coding precision (as reflected in a broader orientation tuning). However, the firing rate of L2/3 PCs remained unchanged. ...
... Sample sizes were chosen to be comparable to sample sizes of other studies in the field, and were not chosen based on statistical methods 20,22,26,48,56 . No data were excluded from the analyses. ...