Dana Leifer's research while affiliated with Weill Cornell Medical College and other places

Publications (3)

Article
Protein Z (PZ) is a vitamin K-dependent plasma protein that exhibits both pro- and anticoagulant properties. Both low and high PZ levels have been linked to ischaemic stroke. Although PZ-lowering gene variants have been found to be less common in ischaemic stroke, the relationship remains unclear. We investigated PZ levels and PROZ variants in a mu...
Article
Background and aims: Circulating lipoprotein (a) [Lp(a)] level relates inversely to apolipoprotein (a) [apo(a)] size. Both smaller apo(a) isoforms and higher Lp(a) levels have been linked to coronary heart disease and stroke, but their independent contributions are less well defined. We examined the role of Lp(a) in younger adults with cryptogenic...
Article
3397 Background In the US, 795,000 patients are diagnosed with stroke annually. Of the 90% of strokes that are ischemic, a substantial number are of unknown etiology. In younger adults, the proportion of such cryptogenic strokes exceeds 40%. Cryptogenic stroke patients have an increased prevalence of interatrial shunts (IAS), which can be found in...

Citations

... We also investigate the function of different genes involved in the duplicated 13q22-q34 region and their possible role on both immunological functions and coagulation pathways. Some of these genes are involved in the coagulation pathway as the Z protein (PROZ) and the Growth arrest-specific gene 6 protein (GAS6) genes, known to play an important role in regulating blood coagulation and in the regulation of thrombotic responses as well as in cerebral haemorrhage, thrombosis and in the genetic susceptibility of systemic lupus erythematosus (SLE) [5,[10][11][12][13][14][15]. In our patient cerebral vasculitis findings associated to LAC positivity could be related also to the involvement of the TNFSF13B (named also B lymphocyte stimulator, BLyS) gene that encodes a cytokine that belongs to the tumor necrosis factor (TNF) ligand family and it is reported to be significantly increased in the primary antiphospholipid syndrome (PAPS) and in LES, as confirmed by an animal model study [16][17][18][19]. ...
... The diagnosis of dyslipidemia was based on the diagnostic criteria of Azadeh Beheshtian's study. 11 Smoking referred to both current and former smokers. ...