Daisy S Precilla's research while affiliated with Sri Balaji Vidyapeeth University and other places
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Publications (5)
Introduction Glioma, coined as a “butterfly” tumor associated with a dismal prognosis. Marine algal compounds with the richest sources of bioactive components, act as significant anti-tumor therapeutics. However, there is a paucity of studies conducted on Fucoidan to enhance the anti-glioma efficacy of Temozolomide. Therefore, the present study aim...
Introduction
Glioma, coined as a “butterfly” tumor associated with a dismal prognosis. Marine algal compounds with the richest sources of bioactive components, act as significant anti-tumor therapeutics. However, there is a paucity of studies conducted on Fucoidan to enhance the anti-glioma efficacy of Temozolomide. Therefore, the present study aim...
Background
An important hallmark of glioblastoma aggressiveness is its altered metabolism of glucose. This metabolic shift wherein the tumor cells employ aerobic glycolysis regardless of oxygen availability via reprogramming of mitochondrial oxidative phosphorylation is known as the Warburg effect. Previous literatures have linked this metabolic re...
Background:
Glioblastoma multiforme is one of the most heterogenous primary brain tumor with high mortality. Nevertheless, of the current therapeutic approaches, survival rate remains poor with 12 to 15 months following preliminary diagnosis, this warrants the need for effective treatment modality. Wnt/β-catenin pathway is presumably the most note...
Citations
... ; https://doi.org/10.1101/2022.12.02.518940 doi: bioRxiv preprint 5 further investigations on this quadruple-drug combination (TCNP). This is because, being a tumor with complex heterogeneity, GB is characterized by aberrant activation of major signal transduction pathways such as PI3K/AKT/mTOR, RAS/RAF/MAPK, Notch, Hedgehog and WNT signalling pathways which contributes to glioma proliferation (Jeuken et al. 2007;Fan and Weiss 2010;Stockhausen et al. 2010;Liu et al. 2011Liu et al. , 2014Precilla et al. 2021;Daisy Precilla et al. 2022). Among these, the WNT/ β -catenin signalling pathway is of paramount importance in gliomagenesis, as it enables GB cells to recapitulate the embryonic processes, thereby promoting glioma growth, progression and therapeutic resistance (Latour et al. 2021). ...
