DK SIMONIK's research while affiliated with Binghamton University and other places
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Publication (1)
Changes in motor behavior and sensory responsiveness were characterized in rat fetuses on gestational Day 21 after acute administration of various doses of cocaine. An increase in fetal motor activity was evident in the 3 highest doses (5, 10, and 20 mg/kg). Cocaine-exposed Ss showed reduced facial wiping in behavioral bioassays of cutaneous sensit...
Citations
... By what structural and/or dynamical mechanisms prenatal exposure to cocaine influences fetal development remains an open question. Our investigations examined the effects of cocaine in an experimental animal model that permits drug administration to individual fetal subjects followed by quantitative observation of their motor behaviors over time (Simonik et al., 1993Simonik et al., , 1994). These studies have shown that cocaine administered into the peripheral circulation or directly into the central nervous system of individual fetal rats produces three-to four-fold increases in motor activity in the forelimbs and hindlimbs lasting several minutes. ...
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