DH McDaniel's research while affiliated with Eastern Virginia Medical School and other places

Publications (9)

Conference Paper
BACKGROUND. Light-emitting diode (LED) photomodulation is a novel nonthermal technology used to modulate cellular activity with light. OBJECTIVE. We describe our experience over the last 2 years using 590 nm LED photomodulation within a dermatologic surgery environment. METHODS. Practical use of nonthermal light energy and emerging applications in...

Citations

... This minimized the potential for bias on account of inter-individual variability among the animals. In terms of the characteristics of the inflicted wound, we opted for removal of all skin layers (deep up to the muscle fascia) and the circular incision was about 2cm in diameter, as the healing time for this wound model is relatively long [9]. These attributes render it well-suited for evaluation of the curative effect. ...
... It has been suggested that LED irradiation stimulates the mitochondria to activate the electron transport chain and thereby up-regulate cellular production of collagen and elastin Kim and Geronemus, 2004). Preliminary investigations by McDaniel et al. (2002aMcDaniel et al. ( , 2002b demonstrated that fibroblast activity, and in particular procollagen synthesis, could be up-regulated in human skin fibroblast culture using light at low fluence. ...
... It has been suggested that LED irradiation stimulates the mitochondria to activate the electron transport chain and thereby up-regulate cellular production of collagen and elastin Kim and Geronemus, 2004). Preliminary investigations by McDaniel et al. (2002aMcDaniel et al. ( , 2002b demonstrated that fibroblast activity, and in particular procollagen synthesis, could be up-regulated in human skin fibroblast culture using light at low fluence. ...
... LEDs are small, robust devices that emit a narrow band of electromagnetic radiation from the ultraviolet to the visible and infrared parts of the spectrum, from around 240 nm up to around 950 nm, according to their electronic structure (Ishida 2005), with a linewidth of around 10À30 nm. LEDs have been publicised as a comfortable, potentially highly selective light-based therapies for many indications (McDaniel et al. 2003). LEDs are also very controllable as light sources for non-thermal applications, acquiring a broad area of in medical applications (Avci et al. 2013). ...
... Translocation of protons begins a pump which ultimately leads to energy for conversion of ADP to ATP, essentially recharging the cell battery and providing more energy for non-mitotic cell processes. McDaniel et al. have demonstrated the rapid production of ATP within mitochrondia within cultured fibroblasts exposed to LED light with the proper sequence or pulsing ''code'' [7,16,17]. This study reports the results of the original prospective multicenter clinical study involving 90 subjects followed for 1 year. ...
... Some preliminary data indicates an anti-inflammatory effect for LED photomodulation following UV induced erythema. Using a solar simulator, preliminary findings indicate a photoprotective effect when delivered after UV radiation [21]. This was predicted based on the reduction of MMP-1 in this study. ...
... Endogenous growth factors, such as basic fibroblast growth factor and insulin-like growth factor, are also upregulated, allowing for cellular proliferation [41]. To explore another LLLT's mechanism of action, Weiss et al., by using RT-PCR and microarray analysis, have demonstrated that LLLT modulates the 5αreductase and vascular endothelial growth factor (VEGF) gene expression, thus stimulating hair growth [42]. Future studies are needed to explore the exact mechanism underlying LLLT stimulation of hair growth. ...