D. Wertheim's research while affiliated with Kingston University and other places

Publications (44)

Article
Identifying the microstructural characteristics of volcanic ash particles is key in developing our understanding of their production, transport and impact. Volcanic glass in ash clouds can damage aircraft engines, surfaces and coatings, and if inhaled cause harm to humans and animals on which they depend. We present results of 3D imaging of volcani...
Article
Managing recurrent wheezing in preschool children is problematic, with conflicting evidence on the effectiveness of asthma therapy. One reason is the heterogeneous nature of preschool wheeze: distinguishing “transient viral wheeze” from asthma at presentation is currently impossible. Bronchodilator response (BDR) measured by interrupter resistance...
Article
Inhalation of radon gas is considered a risk factor in the development of lung cancer. Solid state nuclear track detectors (SSNTDs) are often used for monitoring radon levels. We have previously shown that 3D imaging can help distinguish real tracks from artefact. In this study, we investigated particle tracks in nine SSNTDs using surface and volum...
Article
The properties and performance of collagen-based materials may be affected by the collagen fibre bundle pattern, orientation and weave. The aim of this study was to develop and apply methods to visualize the dermis using confocal laser scanning microscopy from thin tissue sections stained with haematoxylin and eosin. The data was processed to allow...
Article
Wireless mesh networks (WMNs) facilitate both data transfer and real-time applications over wireless medium. Owing to the shared nature of wireless frequencies, bandwidth limitation is a major challenge facing WMNs. If real-time multimedia applications, such as live video streaming, are shared among multiple clients using unicast communications, it...
Article
Full-text available
It has been suggested that 3 to 5% of total lung cancer deaths in the UK may be associated with elevated radon concentration. Radon gas levels can be assessed using CR-39 plastic detectors which are often assessed by 2-D image analysis of surface images. 3-D analysis has the potential to provide information relating to the angle at which alpha part...
Article
To identify a valid method for scoring facial aesthetics, correlating clinicians' assessments with measurements taken from 3D facial photographs. Album assessment of facial images, using a visual analog scale of attractiveness and the scores ranked. Facial ratios, obtained following digitization of the images compared with control group mean data,...
Article
Solid state nuclear track detectors are used to determine the concentration of alpha particles in the environment. The standard method for assessing exposed detectors involves 2D image analysis. However 3D imaging has the potential to provide additional information relating to angle as well as to differentiate clustered hit sequences and possibly e...
Article
Interrupter resistance (R(int)) is a useful measure of airway caliber in young children, but has not been well characterized in infants-in whom there are concerns about the accurate measurement of driving pressure. This study aimed to assess the feasibility and repeatability of measuring R(int) in unsedated newborn infants, and to explore alternati...
Article
This study reports an independent audit of two aspects of orthognathic surgery, namely control of inter-alar width and mandibular outline asymmetry. Measurements were taken from standardized photographs of a consecutive series of 27 patients, using an on-screen digitizing program (IPTool). All patients had undergone bimaxillary osteotomies involvin...
Article
Full-text available
The most important event in the early history of the earth was the separation of its iron-rich core. Core formation induced profound chemical fractionations and extracted into the core most of Earth's iron and siderophile elements (Ni, Co, Au, Pt, W, Re), leaving the silicate crust and mantle with strong depletions of these elements relative to pri...
Article
To investigate whether valid respiratory data can be extracted from the pulse oximeter plethysmographic (pleth) trace in healthy newborn infants, pleth data were collected from the foot, and respiratory airflow was simultaneously measured using a facemask. The pleth waveform was analysed using fast Fourier transform (FFT), low-pass filtering (LPF),...
Article
Interrupter resistance (R(int)) is a widely used measure of airway caliber, but concerns remain about repeatability and sensitivity. Some R(int) variability may derive from the linear back-extrapolation algorithm (LBE 30/70) usually used to estimate driving pressure. To investigate whether other methods of estimating driving pressure could improve...
Article
The aims of this study were to assess the accuracy of measurements recorded by 3D stereophotogrammetry and to compare three methods of facial measurement: manual anthropometry, 3D stereophotogrammetry and 2D photography. Measurements were taken from 14 landmarks on each of six volunteers and compared. In addition, the variability of the methods was...
Article
The letters of Wolfgang Mozart are of considerable interest in musicology, but some of these letters have certain words heavily crossed out. The aim of this pilot study was to investigate the application of digital image processing methods for examining deleted text in a letter by Wolfgang Mozart. The image processing methods used included image en...
Article
Confocal scanning laser microscopy (CSLM) has been used to provide the first images of radon track populations in two external CR-39 plastic detectors. Measurements of variables including track area distribution and estimates of the angle of track inclination (dip) derived from surface CSLM sections are presented. CSLM depth slices, combined with t...
Article
Gastro-oesophageal reflux disease (GORD) occurs in up to 40% of adults in the West. Oesophagitis is a major determinant in the treatment of GORD but its current classification systems are subjective. In order to help to provide objective interpretation of upper gastro-intestinal (GI) endoscope examination and reduce inter-observer variability, we d...
Conference Paper
This paper describes a study of the development of a system for the segmentation of cells in order to help to study their behaviour. The new segmentation technique combines a texture based technique with a contour based technique. The paper presents results of both independent methods applied to analyse neutrophil movement. In addition these result...
Conference Paper
Photo-acoustic spectroscopy appears to be a promising technique for use in non-invasive blood glucose monitoring. In an attempt to improve on current methods we are researching and developing methods for computer analysis of photo-acoustic signals. A computer based data logger was used to acquire signals and the captured data were processed in the...
Article
The aim of this study was to investigate assessment of mandibular asymmetry by clinicians and to evaluate a new computerized system. Eight experienced clinicians (four maxillofacial surgeons and four orthodontists) assessed 12 standardized facial photographs of patients selected to provide a range, from normality to marked mandibular asymmetry. Pho...
Conference Paper
Full-text available
This paper describes a digital image processing system for the analysis of colour in wound images under clinical conditions. The system uses a 3CCD array digital video camera together with a colour scale for reference. The accuracy of colour assessment was compared with clinicians' assessment of the amount of slough (necrotic tissue) in digital ima...
Article
Objective: To investigate the physical parameters of an elasticated tubular bandage (Tubigrip) on the leg and in durability studies. Design and setting: Cohort studies. Participants: Six healthy volunteers and 16 patients. Main outcome measure: Sub-bandage pressure. Results: Median pressures recorded under the Tubigrip bandage system at the lower,...
Conference Paper
It has been suggested that assessment of the outline of the face is useful for determining the effectiveness of treatment for mandibular asymmetry. Standardised frontal-view photographs of 11 patients were digitised and analysed using a newly-developed image analysis system. The face boundary outlines were compared using a number of metrics. Good r...
Conference Paper
Antigenic markers on blood cells can be detected using laser scanning confocal microscopy imaging of fluorescence antibody labelling. The confocal microscopy images provide a series of 2D images. It can be difficult to interpret the data from the 2D images since the continuity of the labels may not be easy to assess. The authors have developed a co...
Conference Paper
Chronic wounds are often painful, debilitating and frequently present a major challenge to clinicians. For example, predicting the healing process may be difficult. Software was written to examine colour and appearance in the vicinity of the wound boundary. The technique was based on a spline delineation of the wound boundary. The software was appl...
Article
Surface antigenic analysis may aid understanding of progenitor cell function. Progenitors can be labelled with specific antibody markers for CD34 and AC 133 and imaged using laser scanning confocal microscopy. At present images are usually assessed visually; however, interpretation can be complicated by background noise and artefact. The aim of thi...
Article
The study of cancer cell motility is considered to be important in understanding cancer metastasis. The movement behaviour of cells within clustered cell colonies is of particular interest. Changes in cell movement, area and velocity can be an indicator of cell spreading. The aim of the study is to develop and apply a computerised interactive image...
Article
A review of some of the basic theories of compression therapy and identification of areas for ongoing research
Article
Compression therapy is widely used in the treatment of venous leg ulcers, but the efficacy of this treatment is variable. Assessment of variation in compression forces associated with movement may help to elucidate the mechanism of action of compression therapy. The aim of this study was to develop and apply a system to investigate forces under com...
Conference Paper
Compression therapy is the principal treatment for leg ulcers associated with venous disease. However, the mechanism of action of this long established treatment is poorly understood. The efficacy of the treatment can be variable which may in part be due to the degree of compression applied. It is not clear whether the assessment of compression sho...
Article
Compression therapy is the principal treatment for leg ulcers associated with venous disease. The efficacy of compression therapy can be variable, which may in part be owing to the degree of compression applied. However, if the mechanism of action of this treatment could be better understood, it might be possible to improve its efficacy. It is not...
Article
Motility of cancer cells is a principal cellular parameter, essentially required in the invasion and formation of distant metastasis in human cancer. Measures to stimulate or inhibit motility of cancer cells may play an important part in the understanding of metastasis biology. The aim of this study was to develop a computer system to analyse and e...
Conference Paper
The authors have developed a system for monitoring pressure and skin temperature associated with compression therapy. The system was applied to investigate forces and skin surface temperature under the 4 layer bandage system in 5 healthy volunteers. At a position about 8 cm above the medial malleolus the authors observed a median pressure of 32 mmH...
Article
Background It has been suggested that poor healing of wounds may be associated with reduced tissue oxygenation. A non-invasive method of assessing peripheral venous oxygenation has been investigated. Method Changes in oxyhaemoglobin (O 2 Hb), deoxyhaemoglobin (HHb), oxidized cytochrome aa 3 (cyt aa 3 ) and total haemoglobin (tHb) were monitored in...
Conference Paper
Compression therapy has been used for centuries to treat venous leg ulcers. However the efficacy of this therapy is variable, which may in part be due to variations in compression applied. However it is not clear whether this should be measured under static or dynamic conditions or both. In order to further investigate the degree of compression app...

Citations

... Such track profiles later were used by some of us (Dörschel et al., 2003;Fromm, 1996;Fromm et al., 1991;Fromm et al., 1993), notably to test capabilities and correctness of etching models. Due to the technical evolution of microscopy and improvement of digital tools several attempts have been made to get insight into the etched track morphology, especially to measure detector response functions based on geometric analyses of etched track wall co-ordinates (Awad, 2001;Fromm et al., 2003;Hermsdorf and Hunger, 2009;Vaginay et al., 2001;Wertheim, 2014;Yu et al., 2005). ...
... The microcirculation of skin has been investigated by spectroscopy in the visible spectral range by some authors (Feather et al, 1988;Kakizoe et al, 1992;Geyer et al, 1996;Sowa et al, 1997;Kakihana et al, 1998). The NIR spectrum was also used to investigate venous oxygen saturation of the subpapillar plexus (Sahlin, 1992;Mancini et al, 1994;Wertheim et al, 1997). First accounts were made to evaluate the spectral re¯ectance data with respect to qualitative and/or quantitative clinical scores. ...
... The measurement of pressures under the device and stiffness of each device cannot be routine for every patient who wears compression stockings or bandages. However, there are several areas where quantifying compression may be of value: quality control of (new) compression products and/or compression techniques, 4,8,11,14,27,[35][36][37][38][39][40][41][42][43][44] proof of concepts (e.g., do we apply graduated compression?), 31,39,45,46 comparative clinical trials (to assess the ''dosage'' of compression applied to individual legs), 8,47 correlation with clinical outcomes or with physiological measurements, 6,24,38,[48][49][50][51][52][53][54][55][56] documentation of clinical care (continuous monitoring), 8,19,43,57 training individuals how to apply compression bandages, 9,[58][59][60] classification of compression bandages, compression stockings, velcro-straps, multi-layer compression systems, 8,71 validation of in vitro measurements, 20,30,56,61,62 compression of stockings to be indicated in mmHg instead of compression classes, 63 evaluation of the level of compression of a bandage, a stocking or a device over time. ...
... Researchers have created high-resolution images of lymph nodes, oral mucosa, the dermis layer of the skin, and auricular cartilage of the joint space. [26][27][28][29] In addition to using Imaris and Amira, researchers have used Voxx (Indiana University, Bloomington, IN, USA) and Vaa3D (Allen Institute for Brain Science, Seattle, WA, USA) to develop 3D renderings of images acquired through benchtop confocal ...
... Such methods are used both in stereovision (Sonka and Fitzpatrik [8]) and in other fields of imaging, i.e. spectral method (Porwik [9]). The methodology of analysis is based on the texture comparison (Korzynska et al. [10], Koprowski et al. [11][12][13][14], Korus et al. [15]) using graphs or correlation analysis. For the majority of these methods, the key problem is extraction of the characteristic features of the image, such as contours (edges), angles and many other features, which would be invariant and able to be searched and found in all the images from the sequence. ...
... This can not only reduce the probability of the sudden drop of the TCP window caused by the loss of some unimportant video packets but also decrease the wireless network load. Besides, as another mainstream communication protocol, user datagram protocol (UDP) cannot provide any congestion control mechanism but can bring less delay, which is commonly used in real-time video and audio streaming services [17]. For wireless real-time multimedia APPs, the authors of [18,19] proposed the UDP-Lite and UDP-Liter protocol to solve the problem of excessive loss rate suffered at the receiver. ...
... One method is to crush and polish the side of the detector to reveal the profiles or longitudinal cross-sections of the drilled paths (Dörschel et al., 1997;Tse et al., 2008). Another method is the use of a confocal microscope through a 3D imaging technique of track profile (Dörschel et al., 2003;Wertheim et al., 2010;. ...
... However, a recent article [17] argues strongly that 3D surface imaging is not enough for "surgical simulations" and that one should employ a model that also includes the complex (non-linear) mechanisms of soft tissues. Other topics using 3D facial surface imaging that are relevant to evaluating clinical outcomes relate to "4D" videos of the dynamics of 3D facial expressions [18] and 3D facial aesthetics [19][20][21]. ...
... Before analysis, the surface of film was sputtered with gold. Three-dimensional surface imaging of the film was performed using a LEXT OLS4100 (Olympus Corporation, Tokyo, Japan) laser confocal microscope, conducted using a similar approach to that previously described [21,22]. ...
... However, in reality the heterogeneous lungs have many different compartments due to highly variable lung compliances (C L ) and lung resistances (R L ) within each compartment, but these differences are difficult to appreciate from the pressure-volume curves measured by the ventilator and even from pulmonary function measurements made at a later stage of sBPD. [28][29][30] During the very early stages of BPD, C L is mostly defined by surface tension forces at the air-liquid interface, i.e., the availability and/or function of surfactant, and less by the extracellular matrix composed of elastin and collagen whose levels are low in the extremely preterm lung. 31 The low levels of elastic elements likely play a role in the difficulties the extremely preterm infant has in maintaining an adequate functional residual capacity (FRC) for efficient gas exchange, accentuated by a highly compliant ribcage. ...