D J Cook’s research while affiliated with McMaster University and other places

What is this page?


This page lists works of an author who doesn't have a ResearchGate profile or hasn't added the works to their profile yet. It is automatically generated from public (personal) data to further our legitimate goal of comprehensive and accurate scientific recordkeeping. If you are this author and want this page removed, please let us know.

Publications (177)


More Than Wishful Thinking: Successful Implementation of the 3 Wishes Project (3WP) in Los Angeles Safety Net Hospitals (SNHs)
  • Conference Paper
  • Full-text available

May 2025

American Journal of Respiratory and Critical Care Medicine

K Bijawat

·

C J Marentes Ruiz

·

D Tarn

·

[...]

·

T H Neville

Rationale: The 3 Wishes Project (3WP) is a low-cost palliative-care initiative in which healthcare workers implement small but meaningful wishes for patients and their families to improve the quality of the end-of-life experience. It has been shown to be a transferrable, affordable, and sustainable program in several academic centers, but has never been implemented in safety-net hospitals (SNHs). SNHs provide largely uncompensated healthcare to low-income and uninsured patients, and unfortunately, are often unable to implement novel palliative care interventions. We hypothesized that the 3WP can be successfully implemented in the intensive care units (ICUs) of SNHs when guided by stakeholder engagement. Methods: A stepped-wedge study design, where implementation was staggered by 2 months, was used to implement the 3WP in 3 Los Angeles SNHs. Prior to implementation, stakeholders from each SNH were engaged in individual semi-structured interviews or focus groups to elicit feedback regarding the 3WP implementation strategy. Informational brochures for families and instructional badge buddies for nurses were created and personalized for each SNH. Per stakeholder suggestions, items that met the cultural and spiritual needs of the SNH's majority Catholic patient population (rosaries, flameless prayer candles, crosses) were purchased for each SNH's 3WP inventory. Depending on stakeholder preference, 2 to 8 training sessions were conducted at each SNH to familiarize nurses with the 3WP goals as well as the logistics of eliciting, fulfilling, and documenting wishes. We show results from the initial 7-month period. Results: Across 3 SNHs, 111 ICU nurses, 3 ICU physicians, 1 Social Worker, 10 Palliative Care Team Members, 2 Spiritual Care Team Members, and 12 3WP Team members implemented a total of 314 wishes for 117 patients (60% of eligible patients). Deceased patients who had 3WP as part of their end-of-life care averaged 62.2 years old, were 61% male, 63% LatinX, and 43% Spanish-speaking only. Categories of wishes included keepsakes (50%, e.g. fingerprints, locks of hair), rituals and spiritual support (19%, e.g. rosaries/crosses), and items to humanize the environment (15%, e.g. decorating hospital room, non-hospital blankets). The direct cost of 3WP averaged 18.79(range:18.79 (range: 0 to $95) per patient. Conclusions: The 3WP is an inexpensive patient and family-centered approach to end-of-life care that can be successfully implemented in culturally diverse SNHs when guided by a methodical implementation strategy. ICU nurses were responsible for the elicitation and implementation of nearly all wishes and are strong champions for this intervention. This abstract is funded by: NIH R01NR020773

Download





Figure 1 Clinical Frailty Scale (CFS) scores
Figure 2 Flow diagram of patients enrolled in CYCLE Pilot RCT by frailty status
Baseline characteristics of patients enrolled in the CYCLE pilot RCT, by frailty status
The Association Between Frailty and Short-Term Outcomes in an Intensive Care Unit Rehabilitation Trial: An Exploratory Analysis

January 2021

·

63 Reads

·

6 Citations

The Journal of Frailty & Aging

Background: Physical therapy initiated early in an ICU stay may reduce functional deficits in critically ill patients; however, the association of frailty with outcomes in those receiving early in-ICU rehabilitation is unknown. Objective: To estimate the association between frailty and 3 outcomes in patients enrolled in an ICU randomized clinical trial (RCT). Design: Exploratory secondary analyses of the CYCLE pilot RCT (NCT02377830). Setting: 7 Canadian ICUs. Participants: Previously ambulatory critically ill adults. Intervention: Participants were randomized to early in-bed cycling plus routine physiotherapy versus early routine physiotherapy alone. Measurements: Using regression analyses, we modelled the association between pre-hospital Clinical Frailty Scale (CFS) scores, Physical Function in ICU Test-scored (PFIT-s), muscle strength, and mortality at hospital discharge, adjusting for illness severity (APACHE II) and the randomized intervention. We explored the influence of imputing mean PFIT-s and strength scores for decedents, and with listwise deletion of decedents in a sensitivity analysis. Results: Of 66 patients, 2 had missing data, 2 had incomplete data, and 21 died by hospital discharge. At hospital discharge for 66 patients, frailty was not associated with PFIT-s (mean difference (MD) [95% CI]=0.20, [-2.08, 2.74]) or muscle strength (1.96, [-12.6, 16.6]). A sensitivity analysis yielded consistent results. Frailty was also not associated with hospital mortality (odds ratio 0.91, [0.28 to 2.93]). Conclusion: We found no association between pre-hospital frailty, physical function, strength, or mortality at hospital discharge in critically ill patients enrolled in an early rehabilitation trial. Larger sample sizes are needed to further explore the association of frailty with these outcomes at hospital discharge.






Citations (61)


... 32 Physiotherapy care is essential for improving ICU patient outcomes. 33 This health service is crucial in managing critically ill patients, particularly those on mechanical ventilation. The primary goal of physiotherapy in critical care settings is to prevent and treat complications associated with immobility and respiratory dysfunction. ...

Reference:

Review of Current Trends in Geriatric Physiotherapy in the Critical Care Setting: Intensive Care Unit Frailty Assessments and Implications for Critical Physiotherapy Practice
The Association Between Frailty and Short-Term Outcomes in an Intensive Care Unit Rehabilitation Trial: An Exploratory Analysis

The Journal of Frailty & Aging

... Many physical rehabilitations have been discussed, for instance, early mobilisation [7] , neuromuscular electrical stimulation [8] , or cycling exercises [9] , passive/active exercises and multicomponent [10] , etc. However, quite a few meta-analyses [11][12][13][14] of these interventions have recently identi ed discordant effects. Therefore, the optimal exercise intervention remains unknown. ...

The Efficacy and Safety of Leg Cycle Ergometry in Critically Ill Adults: A Systematic Review and Meta-Analysis
  • Citing Conference Paper
  • May 2019

... CD is a distressing condition and with treatment options are not a feasible one, patients have poor quality of life. HSc and MSc aims to show beneficial effects in clinical efficacy and gives long term mobilization of cells followed by lower intensity in conditioning of CD therapy [25]. ...

Protocol adherence for continuously titrated interventions in randomized trials: An overview of the current methodology and case study

... The amyloid removal and ARIA incidence data for lecanemab, aducanumab, and donanemab were obtained according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [5] and the Quality of Reporting of Meta-Analysis Conference approach [6]. A systematic literature search to identify publications/reports on randomized controlled trials (RCTs) describing amyloid removal and ARIA incidence data following treatment with lecanemab, aducanumab, and donanemab in patients with Alzheimer's disease up to July 2023 was performed in the PubMed, Web of Science databases and regulatory registry/database (Drugs@ FDA). ...

Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses
  • Citing Article
  • November 1999

The Lancet

... 37 Results of trials evaluating the role of a high PEEP have been inconsistent with regard to its potential benefit. 17,29,38,39 At the bedside, the PEEP can often be adjusted on the basis of responses in individual patients. For example, recruitment can be inferred if the plateau pressure does not rise substantially after the PEEP is increased while the tidal volume remains fixed. ...

A multinational randomized controlled trial of a lung open ventilation strategy in ALI/ARDS - preliminary results
  • Citing Article
  • January 2007

American Review of Respiratory Disease

... Also, combinations utilising rifampicin and pyrazinamide consistently show increased risk of adverse drug reactions (Stout et al., 2003;Leung et al., 2003;Jasmer et al., 2002) and this combination is no longer recommended in the United States (ATS & CDC, 2003). Lower adherence observed with longer courses seems to negate any improvement offered in terms of clinical outcome, with an increase in the risk of associated hepatotoxicity (McNab et al., 2000;Smieja et al., 1999). ...

Review: 6- and 12-month courses of isoniazid prevent active tuberculosis in HIV-negative persons
  • Citing Article
  • July 1999

... 206,208 Several clinical studies have also found that sepsis is related to high levels of Ang-2 and low levels of Ang-1, or high levels of Ang-2/Ang-1 and low levels of Ang-1/Tie-2 ratio. 204,209,210 Ang-1 promotes RECK expression in HUVECs, while the expression of both decreases in sepsis. 211 As a result, we postulate that RECK contributes to sepsis by engaging in Ang/Tie axis-mediated vascular stability. ...

Elevated Plasma Angiopoietin-2 Levels Are Associated With Fluid Overload, Organ Dysfunction, and Mortality in Human Septic Shock

Critical Care Medicine

... 3.1.1. Measurement of protocol adherence and recruitment A priori, we specified that the 5 feasibility objectives for the PROTECT Pilot Study would be considered successful if all of the following were met: [12]: reviewing the protocol; individualizing the protocol to each research ethics board (REB) specification; adapting consent forms to each institution; having meetings and correspondence with relevant disciplines on logistics; procuring REB signature; responding (written) to scientific and ethical REB comments; having in-services; and holding other activities. ...

Research coordinator activities in the ICU: An observational study
  • Citing Conference Paper
  • December 2003

Critical Care Medicine

... We also conducted formal calibration exercises for thrombotic and bleeding events by 4 adjudicators blinded to study drug and each others' assessments. We refined the adjudication guidelines and documented excellent agreement for leg DVTs [42], non-leg DVTs [43], pulmonary embolism [44] and bleeding [45] (kappa 1.0, 0.71, 0.82, 0.81, respectively). Since then, we are randomly allocating all events to adjudication teams for duplicate (venous thrombotic and bleeding events) or quadruplicate (for PE) blinded review. ...

Reference:

S2 Appendix
Adjudicating Bleeding Outcomes in a Large Thromboprophylaxis Trial in Critical Illness.
  • Citing Article
  • November 2009

Blood

... indicating a decrease in psychopathy associated with an increase in endocrine biomarker values. The number of studies, sample sizes, and methodological homogeneity were first considered to determine the appropriate statistical model, following the guidance of Murad et al. (2015) and Tufanaru et al. (2015). Given that only seven studies were included in the meta-analysis, the random-effects model was chosen, besides the fixed-effects model which is considered reliable only when there are fewer than five studies. ...

Fixed-effects and random-effects models
  • Citing Article
  • January 2008