D Christodorescu’s research while affiliated with Institute of Psychiatry and Neurology and other places

... In the clinical interview, we gathered data on whether the patients have previously developed mania or hypomania to differentiate between unipolar and bipolar patients, as bipolar disorder might be related to the Male-DS, especially since bipolar disorder has also been associated with Cluster B personality disorder (Grigoroiu-Serbanescu et al., 1991;Paris et al., 2007). However, in this study, bipolar disorder (as assessed via previous mania or hypomania) was not significantly related to the MDRS-22 score (ANOVA; 17 bipolar patients vs. 128 unipolar patients, marginal means ± standard error: 1.61 ± 0.22 vs. 1.75 ± 0.08, F = 0.4, P = 0.549, sex, F = 0.1, P = 0.795, bipolar/unipolar x sex, F = 0.1, P = 0.720). ...

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Male Depression Syndrome is Characterized by Pronounced Cluster B Personality Traits

... noted neurogenic involvement of the muscle in one case, that of Fontaine et al (1974, cited by 6) who observed neurogenic-type electromyogram and slightly reduced motor conduction velocity in one case, as well as that of Yamanaga et al (1980, cited by 6) who reported clinical and neurophysiological signs of peripheral neuropathy in 3 patients belonging to the same sibship. On sural nerve biopsy Hakamada et al (1981, cited by 6) described segmental demyelination lesions in one patient, and Alexianu et al (1983 Alexianu et al ( , 1995) reported segmental demyelination with secondary axonal degeneration in 2 patients. CCFDN is a genetically homogenous condition, where all patients are homozygous for the same ancestral mutation in the CTDP1 gene on chromosome 18qter (3). ...

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Congenital Cataracts–Facial Dysmorphism–Neuropathy syndrome

... Among individuals with a clinical diagnosis only, sex ratio was 0.97 (1160 males/1198 females) [Collman & Stoller, 1962; Davidenkova et al., 1965; Huether, 1990; Kovaleva et al., 2001; Staples et al., 1991] while among individuals with confirmed trisomy 21 this figure was 1.31 (1918 males/1466 females) [Huether, 1990; Kovaleva et al., 2001; Mikkelsen et al., 1976; Mikkelsen et al., 1990; Sharav, 1991; Staples et al., 1991; Stoll et al., 1990; Wahrman & Fried, 1970]. Correspondingly, in samples where proportion of clinical diagnosis only was 30% and more, intermediate figure of 1.12 (1950 males/1742 females) [Baird & Sadovnik, 1987; Christoderescu et al., 1977; Johnson et al., 1996; Kallen et al., 1996; Kovaleva et al., 2001; Staples et al., 1991] was observed. These observations raised a suggestion that low sex ratio in Down syndrome patients with clinical diagnosis only might be accounted by a large proportion of false positive diagnosis in females [Kovaleva, 2002] 1940 1950 1960 1970 1980 1990 Calendar years Sex ratioFig. ...

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Gender Affects Clinical Suspicion of Down Syndrome

... When we speak of A-T, we speak of a rare disease, but historically the records of the first recognition of the disease started in 1926 [10]. Further clinical pathological explanation of the disease can be found in from the 1940s to the 1950s, when it was considered a clinical syndrome, named Louis-Bar Syndrome [11][12][13][14]. Genetic studies done in the 1960s have confirmed a high family incidence of the disease which is followed by multi-degenerative, multi-systemic affection. ...

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Anesthetic Chalenges And Managment In Patient With Ataxia- Telangiectasia

... A total of 14 studies were included in this systematic review and meta-analysis. From the total, eight of the studies (57.14%) were conducted in the USA [26,[41][42][43][44][45][46][47][48], one in Spain [49], two in the UK [27,50], one in Switzerland [51], one in Romania [52], and one in Israel [29]. From the total, 10 studies selected participants from clinical settings, 3 studies from the general populations, and one study involved both community and institution samples [27,44]. ...

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A Systematic Review and Meta-Analysis of the Risk of Disruptive Behavioral Disorders in the Offspring of Parents with Severe Psychiatric Disorders

... Some studies have compared the differences in immunoglobulin levels between BPD patients and healthy controls. The current findings are inconsistent [20,[35][36][37], which may be related to different inclusion criteria and relatively small sample sizes. Nevertheless, a growing number of studies have found that both BPD and MDD are associated with underlying infections and oxidative stress [38,39]. ...

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Peripheral biomarkers to differentiate bipolar depression from major depressive disorder: a real-world retrospective study

... Après tout, n'est-il pas logique que si la pression génétique sur une maladie est plus grande, cette maladie risquera d'apparaître plus tôt? On retrouve ce phénomène dans plusieurs des syndromes identifiés plus loin, dont le syndrome maniacodépressif (Grigoroiu-Serbanescu et al, 1990;Strober, 1992 ...

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Chapitre 15 PRONOSTIC À LONG TERME

... The production of muscle force entails various events including motor cortex excitation and activation leading to contraction of muscles and changes in this pathway may impair muscle force thereby contributing to muscle fatigue (Wan et al. 2017). Early studies showed that a change in muscle fibers and muscle enzymes, including creatine phosphokinase (CPK), are associated with psychiatric disorders including depression (Segal et al. 2007;Bălăiţă et al. 1990). Three major muscular molecules that control muscle functions are agrin, talin, and titin. ...

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Serum agrin and talin are increased in major depression while agrin and creatine phosphokinase are associated with chronic fatigue and fibromyalgia symptoms in depression

... Family and high risk studies have observed an increased frequency of attention deficit/ hyperactivity disorder (ADHD) in the offspring of parents with major psychiatric disorders (Rieder and Nichols, 1979;Decina et al., 1983;Gershon et al., 1985;Erlenmeyer-Kimling and Cornblatt, 1987;Grigoroiu-Serbanescu et al., 1989; suggesting that childhood ADHD (cADHD) may be an unspecified precursor of the adult psychoses. ...

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Predictive power of the ADHD GWAS 2019 polygenic risk scores in independent samples of bipolar patients with childhood ADHD

... Extraversion scores were lower in BD patients than in the general population. This is in accord with some (Hirschfeld et al., 1986 [female patients]; Smillie et al., 2009), but not all studies, where bipolar patients scored equal (Bech et al., 1980;Carpenter et al., 1999;Clayton et al., 1994;Furukawa et al., 1998;Hirschfeld and Klerman, 1979;Hirschfeld et al., 1986 [male patients]; Liebowitz et al., 1979;Nowakowska et al., 2005;Solomon et al., 1996) or higher (Popescu et al., 1985;Sauer et al., 1997) than controls. The difference in the percentage of subjects with very low extraversion, i.e. less than two standard deviations under the mean extraversion score of the general population, was 2-fold (5% vs. 2.5%) among BD patients compared with the general population, in line with previous studies of BD patients and healthy controls (Hirschfeld et al., 1986). ...

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Differences in neuroticism and extraversion between patients with bipolar I or II or major depressive disorder and general population