Cristina Iulia Mitran's research while affiliated with Carol Davila University of Medicine and Pharmacy and other places

Publications (54)

Article
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There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. Recent studies have shown that ischemia-modified albumin (IMA) is not only an indicator of ischemia...
Article
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Oxidative stress represents the imbalance between oxidants and antioxidants and has been associated with a wide range of diseases. Thiols are the most important compounds in antioxidant defense. There is an equilibrium between thiols and their oxidized forms, disulfides, known as dynamic thiol-disulfide homeostasis (TDH). In 2014, Erel and Neseliog...
Article
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Platelet-rich plasma (PRP) represents a novel therapy tested and is used more and more frequently in dermatology and cosmetic surgery for a variety of conditions, including androgenic alopecia (AGA), a common condition with a complex pathogenesis involving genetic factors, hormonal status and inflammation. We performed an extensive literature searc...
Article
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Since ancient times, people have tattooed their skin for various reasons. In the past, tattoos were associated with low social status; nowadays, tattoos are very popular and are considered a form of art. However, tattoos are associated with various clinical problems, including immune reactions, inflammatory disorders, infections, and even skin canc...
Article
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Cutaneous squamous cell carcinoma (cSCC), a malignant proliferation of the cutaneous epithelium, is the second most common skin cancer after basal cell carcinoma (BCC). Unlike BCC, cSCC exhibits a greater aggressiveness and the ability to metastasize to any organ in the body. Chronic inflammation and immunosuppression are important processes linked...
Article
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The interaction of reactive oxygen species (ROS) with lipids, proteins, nucleic acids and hydrocarbonates promotes acute and chronic tissue damage, mediates immunomodulation and triggers autoimmunity in systemic lupus erythematous (SLE) patients. The aim of the study was to determine the pathophysiological mechanisms of the oxidative stress-related...
Article
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Background: The pathogenesis of chronic spontaneous urticaria involves metabolic, immunological, and psychological factors. The thiol-disulfide exchange reactions could be a mechanism to counteract oxidative stress in patients with chronic spontaneous urticaria. Objective: The assessment of thiol-disulfide homeostasis parameters (TDHPs) accordin...
Article
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Lichen planus (LP) is a chronic, immune-mediated inflammatory skin condition that mainly affects the skin (cutaneous LP, CLP) and oral mucosa (oral LP, OLP). However, the mechanisms involved in the pathogenesis of the disease are not fully elucidated. Over time, several theories that could explain the appearance of LP lesions have been postulated....
Article
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Basal cell carcinoma (BCC) is the most common skin malignancy, which rarely metastasizes but has a great ability to infiltrate and invade the surrounding tissues. One of the molecular players involved in the metastatic process are matrix metalloproteinases (MMPs). MMPs are enzymes that can degrade various components of the extracellular matrix. In...
Article
"Recent research has highlighted the role of oxidative stress in the pathogenesis of HPV-related lesions, especially in neoplastic diseases. Oxidative stress and chronic inflammation are the most important cofactors that HPV requires to persist and induce a malignant process. Data on the role of oxidative stress in benign lesions associated with HP...
Article
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Introduction: Lichen planus (LP) is a mucocutaneous T-cell mediated disorder of unknown etiology. There is growing evidence that oxidative stress is an important player in the pathogenesis of LP. Therefore, we have investigated oxidative stress markers in LP and the influence of hepatitis C virus (HCV) infection, a frequently associated condition,...
Article
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In Romania, cervical cancer is the second most frequent neoplasm among women of 15 to 44 years of age, mainly due to a lack of prevention efforts. The purpose of this study is to assess the current knowledge and attitude towards HPV infection and immunization among medical students. Such information is vital in order to properly assess the current...
Article
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Basal cell carcinoma (BCC) is the most common malignant skin tumor. BCC displays a different behavior compared with other neoplasms, has a slow evolution, and metastasizes very rarely, but sometimes it causes an important local destruction. Chronic ultraviolet exposure along with genetic factors are the most important risk factors involved in BCC d...
Article
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Introduction: Endogenously produced antiganglioside antibodies could affect the evolution of cutaneous melanoma. Epidemiological and experimental evidence suggest "chronic inflammation" to be one of the hallmarks in skin cancers. The aim of the study was to characterize the relation between antiganglioside antibodies and inflammation in cutaneous...
Article
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Cutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer with a complex but not fully understood pathogenesis. Recent research suggests the role of beta human papillomavirus (HPV) types and HPV-associated inflammatory processes in cSCC development. Beta HPV types are components of the normal flora; however, under the influence of ce...
Chapter
Tumour microenvironment is a complex system comprising cells and molecules that will provide the necessary conditions for tumour development and progression. Cells residing in the tumour microenvironment gain specific phenotypes and specific functions that are pro-tumorigenic. Tumour progression is in fact a combination between tumour cell characte...
Article
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Background and objectives: Warts are the most common lesions caused by human papillomavirus (HPV). Recent research suggests that oxidative stress and inflammation are involved in the pathogenesis of HPV-related lesions. It has been shown that the soluble receptor for advanced glycation end products (sRAGE) may act as a protective factor against th...
Article
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The constant generation of reactive carbonyl species (RCSs) by lipid peroxidation during aerobic metabolism denotes their involvement in cell homeostasis. Skin represents the largest organ of the body that is exposed to lipid peroxidation. Previous studies have suggested the involvement of oxidative stress in the development of lichen planus (LP),...
Article
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Oral lichen planus (OLP) is a chronic, immunologically mediated disease, defined by periods of exacerbation and quiescence. The disease is associated with a low mortality risk, but in some instances, morbidity can be important, especially in extensive, erosive forms, with a significant impact on the quality of life. OLP is a chronic T-cell mediated...
Article
Human immunodeficiency virus (HIV) infection continues to be an important public health issue. Immunosuppression is responsible for the development of much comorbidity among HIV-infected patients. Of these, malignancies play an important role in the prognosis of the disease. Cancers diagnosed in HIV-infected patients can be divided into two main ca...
Article
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Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, moni...
Article
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Based on the latest medical research, it is supposed that lichen planus is an inflammatory disorder, associated with autoimmune diseases, hepatitis C infection, oxidative stress or antioxidant deficiency. The purpose of the present work is to determine a panel of serum antioxidants, possibly involved in the development/persistence of the disease. T...
Article
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Lichen planus (LP) is an immune-mediated inflammatory disease that particularly affects the skin and mucous membranes. Its etiology remains elusive, however some trigger factors, including viral or bacterial antigens, drugs and metals, have been postulated. There is a higher prevalence of hepatitis C virus (HCV) infection among patients with LP, wi...
Article
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Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflamm...
Article
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Human papillomavirus (HPV) is a small double-stranded DNA virus with tropism for epithelial cells. To this date, over 150 genotypes are known and are classified into two major groups, low-risk and high-risk strains, depending on the ability of the virus to induce malignant transformation. The host’s immunity plays a central role in the course of th...
Article
Currently there is a significant decline in the vaccination rates which has led to the occurrence of various outbreaks of infectious diseases that can be prevented by vaccination. This situation is the result of several factors, but an inefficient communication strategy seems to play the main role. Most parents assert that there are available many...
Article
Skin lesions can be important signs of a systemic bacterial infection. To examine the skin is easy, thus it is important to know the association between different infections and the cutaneous manifestations they can produce. Sometimes skin manifestations are early signs of the infection, therefore their recognition can be useful for a rapid diagnos...
Article
Human papillomaviruses (HPV) represent a group of deoxyribonucleic acid viruses that contain over 150 distinct types which can cause proliferation of squamous epithelium of the skin and mucous membranes. These viruses are ubiquitous in humans and most often produce benign lesions, such as vulgar warts or condyloma acuminatum. Under certain conditio...
Article
Erythema multiforme is an acute, self-limiting condition with characteristic “target-like” lesions that involve the skin and mucous membranes. It affects subjects of all ages, with a higher incidence among young adults and adolescents. The main factors involved are infectious agents. Most commonly erythema multiforme was reported in association wit...
Article
Chemicals used in the manufacture of synthetic fibers have been associated with undesirable side effects such as itching or skin lesions and it seems that they are involved in the induction of pathological processes such as oxidative stress and inflammation. Lichen planus (LP) can be regarded as an inflammatory disorder, chemical and physical facto...
Article
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Nail psoriasis affects a large number of patients with psoriasis and has a major psychosocial impact. Furthermore, it may be regarded as a predictor of more severe forms of psoriasis and early sign of psoriatic arthritis. The clinical presentations vary depending on the structure affected (nail matrix or nail bed), the nail lesions may range from m...
Article
Objectives. Recent studies have highlighted the role of oxidative stress in the pathogenesis of lichen planus (LP). In the present study the interest of the authors is focused on the investigation of ascorbic acid status in patients with LP and identification of parameters that might influence the level of this vitamin. Material and method. We anal...
Article
Psoriasis is a chronic, immune-mediated disorder characterized by well demarcated, erythematous plaques covered by thick, silvery-white scales, most often located on the knees, elbows, sacral area and scalp. It has a significant impact on the patient's quality of life. Biological therapies revolutionized the treatment of psoriasis vulgaris but ther...
Article
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Acne conglobata is a rare and severe form of acne vulgaris, characterized by the presence of comedones, papules, pustules, nodules and sometimes hematic or meliceric crusts. Acne excoriée is a form of self-inflicted skin condition in which the patient picks on imaginary or real acne lesions. We report the case of a 16 year old Caucasian female pati...
Article
Human papillomavirus (HPV) penetrates the skin or mucous membranes and in most cases undergoes a natural clearance of virus, pertaining to various factors such as skin integrity and efficacy of the immune response. However, in persistent cases that escape the natural clearance mechanism, the infection leads to the development of skin and mucous les...
Article
Psoriasis is a chronic, recurrent inflammatory disorder characterized by the occurrence of well demarcated, erythematous papules and plaques covered by thick, silvery-white scales, generally affecting the elbows, knees, sacral area and scalp. It is a common disorder affecting women during their reproductive years. There is evidence that psoriasis m...
Conference Paper
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Table of contents A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Bucharest Cristian-Mihail Niculae, Eliza Manea, Raluca Jipa, Simona Merisor, Ruxandra Moroti, Serban Benea, Adriana Hristea A2 Influence of bacteriophages on sessile Gram-positive and Gram-negative bacteria...
Article
Mammary Paget's disease is a rare form of cancer, which involves the nipple-areola complex. In most cases it is associated with an underlying tumor of the breast. Diagnosis is based on clinical appearance and is confirmed by histopathological examination. Imaging tests play an important role in detecting the associated ductal carcinoma. We present...
Article
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Introduction: Multi-drug resistant tuberculosis (MDR-TB) is a major concern in the medical community. Knowledge about the drug resistance pattern of Mycobacterium tuberculosis strains plays an essential role in the management of the disease. Material and methods: We conducted a retrospective, 3-year study (2009-2011), in an urban area. We collec...
Article
Hypoactive sexual desire disorder (HSDD) is a condition characterized primarily by the decrease of sexual desire, affecting the quality of life. HSDD seems to be the most common sexual dysfunction in women. Therefore it should not be ignored, but treated. Recently the first drug for the treatment of HSDD, flibanserin, has been approved by FDA. Flib...
Article
Pemphigoid gestationis is a specific autoimmune disease of pregnancy. The onset occurs most commonly in the second or third trimester of pregnancy. Initially, the clinical picture is difficult to distinguish from polymorphic urticarial papules and plaques of pregnancy, urticarial plaques being present in both. Afterwards, the lesions form tense ves...

Citations

... Furthermore, oxidative stress is positively correlated with disease activity [17]. It is related to the fact that the skin harbors a wide range of enzymatic and nonenzymatic compounds that act as antioxidants or oxidant-degrading molecules [18]. ...
... P = 0.016). [30] Most studies that recruited both men and women indicate that PRP treatment may be more effective in male AGA. Several randomized controlled trials have demonstrated synergistic effects of the combination of PRP with oral finasteride and topical minoxidil. ...
... Regarding actinic keratoses, only the serum TSA levels were significantly higher. They suggest that the serum ST6GalI/NEU3 level may be useful in differentiating patients with cSCC from noncancer patients [14]. Dudau et al. showed that sea buckthorn seed oil, a compound rich in long-chain fatty acids known to have beneficial effects on the skin, may promote the proliferation of normal and dysplastic keratinocytes under basal conditions and when they are exposed to UVA irradiation. ...
... At the global level, studies have highlighted a hesitancy vaccinate children using different vaccine types in general [14][15][16][17][18][19][20]. This hesitancy to vaccinate translates to severe consequences. ...
... The authors concluded that the oxidantantioxidant balance is altered in these patients. The most important changes included the impairment of the DNA repair mechanism via 8-oxoguanine DNA glycosylase (OGG1), low serum levels of soluble receptor for advanced glycation end products (sRAGE), which acts as a protective factor against the deleterious effects of inflammation and oxidative stress, the alteration in thiol-disulfide homeostasis, and high nitrotyrosination [12]. ...
... The decreased availability of cysteine, the reduced glutathione pool, the increased production of ROS for long periods of time, and the rapid generation of disulfide bonds represent the main mechanisms that may be responsible for the alteration of TDH in chronic urticaria [43]. Nettis et al. were the first to suggest the role of advanced oxidation protein products (AOPPs) in urticaria. ...
... One of the by-products of polyunsaturated fatty acid peroxidation in cells is malondialdehyde [39]. An increase in free radicals leads to an excess synthesis of malondialdehyde. ...
... Tampa et al. corroborated that MMP 10 enhances the process of cell migration. This phase that is the repairing phase of wound healing which includes various cellular responses such as migration, proliferation and differentiation and even cell death [72,73]. Now, it is quite evident that these events or responses either separately or collectively are able to generate MMPs due to the line of action of these proteinases that have been deciphered up until now. ...
... If they accumulate, they exert harmful effects on cellular structure and function. The main mechanism by which AGEs interfere with biological functions is the activation of specific transmembrane receptors for advanced glycation end-products [22,23]. ...
... A scheme outlining the major gene-related biomarkers in skin cancers and their propensity to develop a targeted therapy is presented in Figure 2. Yet, there is increasing evidence that patients with advanced NMSCs may also benefit from the successes of immunotherapies with anti-CTLA-4 and anti-PD-1 monoclonal antibodies [129,130]. However, although immunotherapies and targeted therapies have greatly improved the clinical outcome and OS in skin cancer patients, their efficiency is often limited by the increased genomic and immune heterogeneity of tumors, calling for even more refined approaches for skin cancer treatment and monitoring [21,22]. LB, which relies on the analysis of circulating components derived from the tumors within body fluids, has recently emerged as a powerful tool for monitoring disease evolution and therapeutic responses in skin cancer patients. ...