Conrado Rodríguez Martín’s scientific contributions

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Publications (1)


Pre-Columbian tuberculosis in Tierra del Fuego? Discussion of the paleopathological and molecular evidence
  • Article

December 2015

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404 Reads

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21 Citations

International Journal of Paleopathology

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Anne C. Stone

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Conrado Rodríguez Martín

This work contributes to ongoing discussions about the nature of tuberculosis in the Western Hemisphere prior to the time of European contact. Our example, from the extreme south of South America was, at the time of our study, without firm temporal association or molecular characterization. In Tierra del Fuego, Constantinescu (1999) briefly described vertebral bone lesions compatible with TB in an undated skeleton from Myren 1 site (Chile). The remains of Myren are estimated to represent a man between 18 and 23 years old at the time of death. The objectives of this research are to extend this description, to present molecular results, to establish a radiocarbon date, and to report stable isotopic values for the remains. We provide further description of the remains, including tuberculosis-like skeletal pathology. Radiocarbon dating of 640 20 years BP attributes this individual to the precontact fourteenth-fifteenth centuries. Isotopic ratios for nitrogen and carbon from bone collagen suggest a mixed diet. Molecular results were positive for the rpoB quantitative PCR (qPCR) assays but negative for two independent IS6110 and IS1081 qPCR assays. Further testing using genomic methods to target any mycobacteria for specific identification are needed.

Citations (1)


... Molecular studies confirmed TB in ancient human remains from necropoles in Ancient Egypt [78], Asia [79,80], America [81][82][83][84], and Europe [77,[85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100]. These authors reported aDNA extracted and analyzed and positively tested for MBTC, both from vertebral lesions and highly associated lesions. ...

Reference:

The Evolution of Diagnostic Techniques in the Paleopathology of Tuberculosis: A Scoping Review
Pre-Columbian tuberculosis in Tierra del Fuego? Discussion of the paleopathological and molecular evidence
  • Citing Article
  • December 2015

International Journal of Paleopathology