Claudia Wigmann’s research while affiliated with Leibniz Research Institute for Environmental Medicine and other places

... The human skin is frequently exposed to considerable amounts of infrared (IR) radiation and visible light from sunlight, which can increase the skin temperature and induce skin aging [48,49]. As such, heat stress due to IR and visible light from sunlight has been shown to affect melanogenesis in vitro [50] and pigmentation clinically [51,52]. Several in vitro and ex vivo have demonstrated that exposure to increased temperature can affect skin pigmentation. ...

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The Efficacy of Apple Mint Extract as a Nutraceutical Supplement for Skin Brightening: A Double-Blind, Randomized, Placebo-Controlled Clinical Study

... Mineral dust (MD) pollution has become a major global health concern [1,2,3,4,5,6,7]. This issue is expected to grow in importance due to Earth's changing climate and the increasing mobilization of crustal material into the atmosphere [8,9]. ...

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Particle-bound mercury in Saharan dust-loaded particulate matter in Cabo Verde

... One of the major issues arisen in recent years is that environmental pollution can accelerate aging [3]. Air pollution, jointly with genetic and life-style risk factors, including tobacco smoking, alcohol drinking and unsafe diet, contributes significantly to aging [4,5]. Air pollution exposure can shorten life expectancy even among people with the best genetic makeup. ...

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The effect of high polycyclic aromatic hydrocarbon exposure on biological aging indicators

... as the nervous system [3],the immune system [4],the endocrine system [5]and the reproductive system [6]. Air particulate matter can enter the body and cause direct damage to the respiratory tract [7]. Long-term exposure to ozone pollution may lead to airway inflammation and decreased lung function [8],and eye irritation [9]. ...

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The relationship between air pollutants and preterm birth and blood routine changes in typical river valley city

... Genotyping for GINIplus and LISA was conducted using Affymetrix Chip 5.0 and 6.0 (Thermo Fisher, USA) in Munich and Infinium Global Screening Array GSA v2 MD (Illumina, USA) in Wesel. Quality control and genotype imputation details were previously published [36,37]. PRS for BMI were computed according to 97 genome-wide significant single nucleotide polymorphisms (SNPs) [38]. ...

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Accelerometry-assessed sleep clusters and obesity in adolescents and young adults: a longitudinal analysis in GINIplus/LISA birth cohorts

... Tree-based statistical learning methods were also tested for better PRS construction [79], showing that random forest and logic bagging outperform other tree-based (logic regression, elastic net, and RF-VIM) methods for predicting rheumatoid arthritis. ...

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Machine Learning to Advance Human Genome-Wide Association Studies

... Our findings offer the first empirical, epidemiological evidence that PM 2.5 may increase risk of heatrelated hospitalization. In contrast to prior work, which has largely framed temperature as a modifier of the health effects of air pollution (Li et al., 2017;Areal et al., 2022;Anenberg et al., 2020), our focus on explicit heat-related hospitalizations reveals that PM 2.5 may also modify the health effects of heat. ...

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An investigation of air pollution-induced temperature sensitivity and susceptibility to heat-related hospitalization in the Medicare population

... The mean NDVI surrounding the residence was assessed considering different street-based buffers: 100, 300 and 500 m. These distances align with previous research on the influence of green space on older adults' mental health (Altug et al. 2021, Peng et al. 2022. ArcGIS Pro 2.3.0 was used to process satellite images and extract the mean NDVI in the residence surroundings. ...

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Exposure to green and blue spaces and depression among older adults from the EPIPorto cohort: examining environmental, social, and behavioral mediators and varied space types

... In recent decades, a growing number of investigations have suggested an nexus between extreme heat and cognitive function over the globe (Yeganeh et al., 2018;Zhang et al., 2019), while population-based evidence remained extensively sparse in densely-populated and climate-sensitive LMICs such as China (Dai et al., 2016;Zhao et al., 2021). Although recent studies from Europe (Gong et al., 2022b) and North America (Cedeno Laurent et al., 2018) have linked high temperature exposure to cognitive decline, these findings could not be directly generalized to the Chinese population, owing to substantial between-region differences in climatic conditions and population susceptibility and adaptiveness. ...

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Cognitive decline in relation to later-life high temperature exposure in a Chinese nationwide cohort

... 7 Mendelian randomization studies have suggested that confounding by smoking alone does not explain the relationship between lung function and mortality. 8 9 Few studies, however, have reported the potential mediating role of impaired lung function on the associations between air pollution and mortality or CVD outcomes, 10 in particular in subgroups that differ by smoking status. Previous studies have shown that the effect of air pollution on lung function may differ by smoking status; 2 effects of air pollution in ever-smokers have been hypothesised as being harder to detect, since smoking may already impair lung function via similar pathways to air pollution. ...

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Air pollution, lung function and mortality: survival and mediation analyses in UK Biobank