Claudia Weidling's research while affiliated with IT University of Copenhagen and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (7)
Depolarizing sodium (Na⁺) leak currents carried by the NALCN channel regulate the resting membrane potential of many neurons to modulate respiration, circadian rhythm, locomotion and pain sensitivity1–8. NALCN requires FAM155A, UNC79 and UNC80 to function, but the role of these auxiliary subunits is not understood3,7,9–12. NALCN, UNC79 and UNC80 ar...
Persistently depolarizing sodium (Na+) leak currents that enhance electrical excitability have been described for decades1,2. The entity responsible for the major background Na+ conductance in neurons had remained a mystery until characterization of NALCN (Na+leak channel, non-selective)3,4. NALCN-mediated currents regulate neuronal excitability li...
The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations are life-threatening in humans and knockout is lethal in mice. However, the basic functional and pharmacological properties of NALCN have remained elusive. Here, we found that robust function of NALCN in heterologous systems requires co-expression of UNC79, UNC80,...
The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations are life-threatening in humans and knockout is lethal in mice. However, the basic functional and pharmacological properties of NALCN have remained elusive. Here, we found that the robust function of NALCN in heterologous systems requires co-expression of UNC79, UN...
Citations
... An extra interface between the I-II linker of NALCN and UNC79 C-half identified in that work was not observed in our study, probably due to different sample conditions ( Supplementary Fig. S7). It seems that I-II linker is not as essential as the II-III linker in association between NALCN and the UNC79-UNC80 subcomplex, as alterations of the I-II linker did not obviously impact the channelosome function 26 . The absence of the I-II linker interacting interface in our study suggests that it is highly dynamic, which in turn leads to a more pronounced local conformational flexibility (Supplementary Video S1). ...
Reference: Architecture of the human NALCN channelosome
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1139332232552449-1648649380721_Q64/Nourdine-Chakouri.jpg)
... However, the auxiliary subunits of the NALCN channelosome are unique and share no sequence homology to the auxiliary subunits of other 4 × 6 TM channels. Among the auxiliary subunits, FAM155A may facilitate the folding and membrane translocation of NALCN through forming a stable subcomplex with NALCN [17][18][19] . UNC79 and UNC80 are large proteins that have been reported indispensable for neuronal localization in mice 9 and robust circadian locomotor rhythms in Drosophila 6 . ...
Reference: Architecture of the human NALCN channelosome
... NALCN forms a unique complex termed NALCN channelosome with the auxiliary subunits FAM155A, UNC79, and UNC80 [5][6][7] . The formation of the NALCN channelosome is critical to a fully functional Na + conductance carried by NALCN 8 . Knockout of NALCN, UNC79, or UNC80 is lethal in mice 1,9,10 . ...
Reference: Architecture of the human NALCN channelosome
