April 2011
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33 Reads
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1 Citation
Piel
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Publications (5)
July 2010
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3 Reads
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2 Citations
Inmunología
Skin lesions are the most visible and frequent symptoms in lupus erythromatosus (LE). These lesions vary greatly in their clinical as well as microscopic features, which difficults the understanding and study of LE. Most of the patients that express skin disease do not suffer from serious systemic complications, but from important morbidity given the extension, chronicity, chances of scarring and disfigurement that skin lesions may cause. The exact pathogenic mechanisms that induce the development of skin lesions in LE are unknown at present; however, ultraviolet (UV) radiation could play an important role. UV- induced keratinocyte apoptosis as well as proinflammatory stimuli release because of uncomplete apoptotic cell clearance may be the pillars of the etiology of this skin disease. Nonetheless, there are still many questions to answer. The treatment consists of photoprotection, topical administration of corticoids as well as oral administration of antimalarial drugs.
July 2010
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27 Reads
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7 Citations
Inmunología
Skin lesions are the most visible and frequent symptoms in lupus erythromatosus (LE). These lesions vary greatly in their clinical as well as microscopic features, which difficults the understanding and study of LE. Most of the patients that express skin disease do not suffer from serious systemic complications, but from important morbidity given the extension, chronicity, chances of scarring and disfigurement that skin lesions may cause. The exact pathogenic mechanisms that induce the development of skin lesions in LE are unknown at present; however, ultraviolet (UV) radiation could play an important role. UV- induced keratinocyte apoptosis as well as proinflammatory stimuli release because of uncomplete apoptotic cell clearance may be the pillars of the etiology of this skin disease. Nonetheless, there are still many questions to answer. The treatment consists of photoprotection, topical administration of corticoids as well as oral administration of antimalarial drugs.
November 2009
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26 Reads
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3 Citations
Piel
October 2008
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226 Reads
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6 Citations
Piel
Citations (2)
... El compromiso de piel en el LES presenta una variedad importante. Si bien la alopecia sin cicatriz y el rash fotosensible siguen siendo prevalentes, no se encontraron en más del 50% de nuestros pacientes y fueron más frecuentes en mestizos que en blancos y criollos 16 . Tampoco fue muy relevante la presencia de eritema malar y de úlceras orales, que estuvieron presentes en no más del 32% de los pacientes, prevaleciendo en mestizos y en blancos, siendo infrecuente en toda la muestra la presencia de úlceras nasales, como así también otras formas de compromiso dérmico descriptos por otros autores como lupus tumidus, hipertrófico o ampollar 17,18 . ...
- Citing Article
July 2010
Inmunología
... Although few studies have evaluated photoaging in patients treated with light therapy, an increase in light damage can be observed in patients who have received long treatments, as demonstrated both in experimental studies and clinical practice. [21][22][23] Hence, it is important to minimize this risk as it occurs with carcinogenesis. We should limit the number of treatments and recommend light protectors to block UV radiation from the environment. ...
- Citing Article
October 2008
Piel