Chun-Yen Yu's research while affiliated with Chang Gung Memorial Hospital and other places

Publications (53)

Article
Full-text available
Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is a histopathological marker and risk factor for HCC recurrence. We integrated diffusion-weighted imaging (DWI) and magnetic resonance (MR) image findings of tumors into a scoring system for predicting MVI. In total, 228 HCC patients with pathologically confirmed MVI who underwent surg...
Article
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Background: Since the advent of a new generation of inflow-sensitive inversion recovery (IFIR) technology, three-dimensional non-contrast-enhanced magnetic resonance angiography is being used to obtain hepatic vessel images without applying gadolinium contrast agent. The purpose of this study was to explore the diagnostic efficacy of non-contrast-e...
Article
Background To evaluate the significance of portosystemic shunts and associated long-term outcomes in living donor liver transplant (LDLT) among pediatric patients. Methods Retrospective review of 121 pediatric patients who underwent LDLT between May 1994 and December 2015 at Taiwan Kaohsiung Chang Gung Memorial Hospital. Pre- and postoperative com...
Article
Background Gadolinium-ethoxybenzyl-diethylene triamine pentaacetic acid (Gd-EOB-DTPA) is a newer magnetic resonance contrast that has the combined effect of conventional and liver-specific contrast. The use of Gd-EOB-DTPA may aid in management of patients with hepatocellular carcinoma (HCC) undergoing living donor liver transplant (LDLT). Material...
Article
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Despite technological and immunological innovations, living-donor liver transplant (LDLT) recipients still face substantial risk of postoperative complications. Sarcopenia is being recognized more and more as a biomarker that correlates with poor outcomes in surgical patients. The purpose of this study was to evaluate the relationship between sarco...
Article
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The objective of this study aimed to develop biodegradable calcium alginate microspheres carrying doxorubicin (Dox) at the micrometer-scale for sustained release and the capacity of pH regulatory for transarterial chemoembolization. Ultrasonic atomization and CaCl2 cross-linking technologies were used to prepare the microspheres. A 4-by-5 experimen...
Preprint
Full-text available
The objective of this study aimed to develop biodegradable calcium alginate microspheres carrying doxorubicin (Dox) at the micrometer-scale for sustained-release and the capacity of pH regulatory for transarterial chemoembolization. Ultrasonic atomization and CaCl2 cross-linking technologies were used to prepare the microspheres. A 4 by 5 experimen...
Preprint
Full-text available
Purpose Despite technological and immunological innovations, living-donor liver transplant (LDLT) recipients still face substantial risk of postoperative complications. Sarcopenia is being recognized more and more as a biomarker that correlates with poor outcomes in surgical patients. The purpose of this study was to evaluate the relationship betwe...
Article
Full-text available
Background: Despite the increasing number of laparoscopic hepatic procedures for the resection of hepatocellular carcinoma (HCC), intraoperative tumor localization and demarcation remains challenging in comparison to open surgery. In this study, we evaluated the feasibility of positive liver segment staining through the super-selective intra-arter...
Article
Purpose The purpose of this study was to assess the safety and efficacy of drug-eluting embolic (DEE) transarterial chemoembolization for hepatocellular carcinoma (HCC) in patients who are ineligible for curative treatment, using doxorubicin-loaded Tandem (Varian Medical) microspheres. Materials and Methods Between October 2015 and December 2017,...
Article
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BACKGROUND Early hepatic artery thrombosis (eHAT) is a severe arterial complication leading to biliary complications and graft failure in living donor liver transplantation (LDLT). This study sought to early identify the abnormal waveforms of eHAT by using intensive Doppler ultrasonography (DUS) after LDLT and to assess the clinical outcome in thes...
Article
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Background The purpose of this study was to assess the value of functional MRI (fMRI) of post-doxorubicin drug-eluting beads transcatheter arterial chemoembolization (DEB-TACE) for hepatocellular carcinoma (HCC) as an early imaging biomarker of response to therapy. Methods This prospective analysis included 21 consecutive patients undergoing fMRI...
Article
Purpose: We aimed to compare the safety and effectiveness of 100-300 μm versus 300-500 μm drug-eluting bead transarterial chemoembolization (DEB-TACE) and to investigate the impact of tumor and feeding artery size on treatment outcome of different particle sizes in the treatment of hepatocellular carcinoma (HCC). Methods: This retrospective coho...
Article
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Background: Tumor recurrence is the major risk factor affecting post-transplant survival. In this retrospective study, we evaluate the prognostic values of magnetic resonance (MR) diffusion-weighted imaging (DWI) in liver transplantation for hepatocellular carcinoma (HCC). Methods: From April 2014 to September 2016, 106 HCC patients receiving li...
Article
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Correction for ‘PCL–DOX microdroplets: an evaluation of the enhanced intracellular delivery of doxorubicin in metastatic cancer cells via in silico and in vitro approaches’ by Aman Chandra Kaushik et al. , New J. Chem. , 2019, DOI: 10.1039/c9nj01902b.
Data
A schematic diagram of HCC Q3 ; the liver blood and nutrients are supplied 25% by the hepatic artery and 75% by the hepatic portal vein. Conversely, the blood and nutrients supplied to the tumor are mostly from the hepatic artery. A schematic diagram of TACE; injections of HepaSphere with DOX are made into the femoral artery, abdominal aorta, and h...
Data
A schematic diagram of HCC Q3 ; the liver blood and nutrients are supplied 25% by the hepatic artery and 75% by the hepatic portal vein. Conversely, the blood and nutrients supplied to the tumor are mostly from the hepatic artery. A schematic diagram of TACE; injections of HepaSphere with DOX are made into the femoral artery, abdominal aorta, and h...
Article
Full-text available
Researchers promoted polymer microspheres in medical engineering and biotechnology such as embedded drug delivery of poly lactic acid microspheres. Polycaprolactone (PCL) is kind of semi-crystalline polymer which was utilized in many varieties of organic solvents. Therefore, PCL was made as drug-controlled releasing carriers for long-term treatment...
Article
Abstarct The objective was to investigate the upstream mechanisms of apoptosis which were triggered by a novel antimicrotubule drug, ABT‐751, in a tumor protein p53 ( TP53)‐deficient hepatocellular carcinoma‐derived Hep‐3B cells. A series of in vitro assays indicated that ABT‐751 caused the disruption of the mitotic spindle structure, collapse of m...
Article
Objective The aim of the study was to evaluate the efficacy of liver fibrosis (LF) with acoustic radiation force impulse (ARFI) elastography for post-transplant (post-LT) HCV recurrence. Patients and methods We enrolled 89 adult recipients of living donor liver transplantation (LDLT) who had HCV, with or without post-LT HCV recurrence and treated...
Article
Objective The aim of this study is to determine whether post-transarterial chemoembolization imaging (computed tomography or magnetic resonance imaging) could accurately predict the tumors' necrosis on pathologic specimens. Background Transarterial chemoembolization with drug-eluting beads has been proven to be an effective way to bridge patients...
Article
Purpose To evaluate long-term efficiency of hepatic venous balloon angioplasty (BA) and stent placement (SP) for hepatic venous outflow obstruction (HVOO) in pediatric liver transplants (LT). Materials and Methods From January 1999 to September 2016, 262 pediatric patients received LT in our hospital. 10 patients were diagnosed of HVOO, including...
Article
Objectives This study aims to investigate post-donation outcomes of adult living donor liver transplantation (ALDLT) donors and remnant liver regeneration in different graft types. Methods A total of 236 ALDLT donors were classified into different groups: donors with < 35% remnant liver volume (group A; n = 56) and donors with remnant liver volume...
Article
Objectives: Our aim was to identify ultrasound criteria that may be used to detect portal vein stenosis (PVS) in adult living donor liver transplantation (ALDLT) with left lobe grafts. Methods: 171 recipients underwent primary left lobe graft aldlt and routine liver doppler ultrasound (DUS) as protocol. Another 151 right lobe liver donors who under...
Article
Full-text available
The aim of this study was to understand the difference between the measured and calculated irradiation attenuations obtained using two algorithms and to identify the influence of couch attenuation on patient dose verification. We performed eight tests of couch attenuation with two photon energies, two longitudinal couch positions, and two rail posi...
Article
Full-text available
The shortage of deceased donor liver grafts led to the use of living donor liver transplant (LDLT). Patients who undergo LDLT have a higher risk of complications than those who undergo deceased donor liver transplantation (LT). Interventional radiology has acquired a key role in every LT program by treating the majority of vascular and non-vascular...
Article
Portal vein (PV) complications after living donor liver transplant (LDLT) have been a major concern in pediatric liver transplantation. The incidence of PV complications is more in pediatric (0%-33%) than in adult recipients. Early diagnosis and treatment of PV complications may ensure optimal graft function and good recipient survival. Small preop...
Article
Preoperative evaluation of donors for living-donor liver transplantation aims to select a suitable donor with optimal graft quality and to ensure donor safety. Hepatic steatosis, a common finding in living liver donors, not only influences the outcome of liver transplantation for the recipient but also affects the recovery of the living donor after...
Article
Preoperative evaluation of donors for living-donor liver transplantation aims to select a suitable donor with optimal graft quality and to ensure donor safety. Hepatic steatosis, a common finding in living liver donors, not only influences the outcome of liver transplantation for the recipient but also affects the recovery of the living donor after...
Article
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To determine the impact of body-mass factors (BMF) before radiotherapy and changes during radiotherapy on the magnitude of setup displacement in patients with head and neck cancer (HNC). The clinical data of 30 patients with HNC was analyzed using the alignment data from daily on-line on-board imaging from image-guided radiotherapy. BMFs included b...
Article
This study compared TomoTherapy (TM), with Volumetric-Modulated Arc Therapy (RapidArc, RA), and dynamic intensity-modulated radiotherapy (dIMRT) for locally advanced esophageal cancer (LAEC) with a simultaneous integrated boost (SIB) technique with regard to the target coverage and sparing of organs at risk (OARs). Twelve patients receiving four-di...
Article
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Dose distributions of (192)Ir HDR brachytherapy in phantoms simulating water, bone, lung tissue, water-lung and bone-lung interfaces using the Monte Carlo codes EGS4, FLUKA and MCNP4C are reported. Experiments were designed to gather point dose measurements to verify the Monte Carlo results using Gafchromic film, radiophotoluminescent glass dosimet...
Article
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A combination of four-dimensional computed tomography with (18)F-fluorodeoxyglucose positron emission tomography (4D CT-FDG PET) was used to delineate gross tumor volume (GTV) in esophageal cancer (EC). Eighteen patients with EC were prospectively enrolled. Using 4D images taken during the respiratory cycle, the average CT image phase was fused wit...
Article
Cycling hypoxia is a well-recognized phenomenon within animal and human solid tumors. It mediates tumor progression and radiotherapy resistance through mechanisms that involve reactive oxygen species (ROS) production. However, details of the mechanism underlying cycling hypoxia-mediated radioresistance remain obscure. We have previously shown that...
Article
In living donor liver transplantation (LDLT), the essential aims are to provide an adequate graft volume to the recipient and to keep a sufficient remnant liver volume in the donor. In some instances, these aims cannot be met by a single donor and LDLT using dual grafts from two donors is a good solution. From 2002 to 2009, five recipients in our h...
Article
Chen H-L, Tsang LL-C, Concejero AM, Huang T-L, Chen T-Y, Ou H-Y, Yu C-Y, Chen C-L, Cheng Y-F. Segmental regeneration in right-lobe liver grafts in adult living donor liver transplant. Abstract: Our aim is to evaluate the relationship and impact of right-lobe (RL) liver grafts procured with or without the middle hepatic vein (MHV) trunk and MHV trib...
Article
Exact knowledge of biliary anatomy is essential in living donor liver transplantation. The purpose of this study was to evaluate the accuracy of pretransplant magnetic resonance cholangiography (MRC) in depicting the biliary anatomy in comparison with intraoperative cholangiography (IOC). From May 2006 to July 2009, 451 potential living liver donor...
Article
The aim of this study is to evaluate the feasibility of using cone-beam CT system as a near real-time measurement device in dose estimation with normoxic polymer gel dosimetry (MAG). Each vial was filled with MAG gel and irradiated with uniform doses of 0–10 Gy to generate dose response curves. After irradiation, a cone-beam CT was used to perform...
Article
Vascular complications are major complications after living donor liver transplantation (LDLT), especially in biliary atresia (BA). Early diagnosis and treatment of portal vein thrombosis (PVT) may ensure optimal graft function and good recipient survival. Our aim was to find any association between pre- and post-transplant anatomic characteristics...
Article
Full-text available
Glioblastoma multiforme (GBM) tumors are the most common type of brain tumors and resistance to radiotherapy. This study aimed to investigate the differential effect and mechanism of tumor microenvironments, cycling hypoxia and non-interrupted hypoxia, on tumor cell radiosensitivity in the human U87 glioblastoma tumor model. We exposed U87 cells an...
Article
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Parenchymal pseudoaneurysm of the hepatic arteries with massive intraperitoneal bleeding is rare but a serious life-threatening complication when it occurs following liver transplantation. We report a case of an adult postliving donor liver transplant recipient who developed massive subcapsular bleeding combined with massive right pleural effusion...
Article
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Refracture of cemented vertebrae is often seen after percutaneous vertebroplasty. The purpose of this prospective study was to evaluate pre-procedural magnetic resonance images (MRI) for the prediction of further collapse and vertebral height loss after vertebroplasty. This study included 81 consecutive patients (73 women and 8 men) with osteoporot...
Article
To examine the prevalence rate and predictors of alcohol use problems among patients undergoing methadone maintenance treatment (MMT). This was a prospective follow-up study. Study population included 438 patients who underwent more than 6 months of MMT. Demographic and clinical characteristics were collected for each patient prior to treatment, an...
Article
Full-text available
To define a suitable threshold setting for gross tumor volume (GTV) when using 18Fluoro-deoxyglucose positron emission tomography and computed tomogram (PET/CT) for radiotherapy planning in head and neck cancer (HNC). Fifteen HNC patients prospectively received PET/CT simulation for their radiation treatment planning. Biological target volume (BTV)...
Article
This study aimed to assess the dose-rate effect of (192)Ir source activity on pelvic control and late complications following high-dose-rate intracavitary brachytherapy (HDRICB) for cervical cancer patients. Two hundred and twelve patients were enrolled in this study. They were treated with external beam radiotherapy to the pelvis, after which HDRI...
Article
Thermoluminescent dosimeters are widely applied in the measurement of radiation dose. Since the luminescent centers are not lost during the reading process, radiophotoluminescent glass dosimeters (RPLGDs) can be repeatedly readout. The aims of this study were to make RPLGD and to analyze its physical and chemical properties. This study used chemica...
Article
LT is the definitive treatment option in the management of end-stage liver disease. Preoperative vascular evaluation plays an important role for a safe and successful operation in LDLT. The purpose of this study is to assess the usefulness and accuracy of CTA and MRA in evaluating vascular anomalies in BA patients undergoing LDLT. Images of CTA and...
Article
This study was undertaken to assess local control and toxicity with adjuvant intensity-modulated radiotherapy (IMRT) and concurrent chemotherapy (CCRT) for early stage cervical cancer. Between June 2004 and February 2007, 54 patients with early stage cervical cancer (stage IB-IIA) with high-risk factors for treatment failure after surgery were trea...
Article
To investigate risk factors for new vertebral compression fractures (VCFs) after vertebroplasty. The authors analyzed the occurrence of new VCFs in 70 patients who had previously undergone vertebroplasty for the treatment of one VCF. The following covariates were analyzed: age, sex, body weight, height, body mass index (BMI), treated vertebral leve...
Article
To assess local control and acute and chronic toxicity with intensity-modulated radiation therapy (IMRT) as adjuvant treatment of cervical cancer. Between April 2002 and February 2006, 68 patients at high risk of cervical cancer after hysterectomy were treated with adjuvant pelvic radiotherapy and concurrent chemotherapy. Adjuvant chemotherapy cons...

Citations

... The above studies show that although TIPS can well control and prevent GV bleeding, its clinical efficacy is roughly equivalent to EV, and it also has a high risk of postoperative hepatic encephalopathy. In recent years, due to the application of stent graft and the control of shunt diameter, the clinical application effect of TIPS has been more and more affirmed [44][45][46]. ...
... Sarcopenia is a major feature of malnutrition in patients with liver disease and is an important indicator affecting the prognosis of patients with end-stage liver disease (ESLD) (1). Numerous studies (2)(3)(4)(5) have used the skeletal muscle index at the third lumbar vertebrae (L3-SMI) to determine sarcopenia, to further evaluate the association between sarcopenia and the prognosis of patients with chronic liver disease (CLD), and also some studies have evaluated the impact of the psoas muscle index (PMI) on the prognosis of CLD (6,7). Studies (8)(9)(10)(11) have shown that sarcopenia can be valuable as a predictor of disease progression, complications of cirrhosis such as the incidence of hepatic encephalopathy, mortality of cirrhotic patients, long-term outcome after liver transplantation, and outcome of patients with HCC. ...
... With the guidance of DSA examination, Grade 4 (or higher) hepatic arteries could be reached; thus, the liver watershed (or sub-segment) staining could be achieved via injection of the ICG through the aimed hepatic artery. Li et al. have proved that intra-arterial ICG injection provided a real-time image-guided intraoperative demarcation of targeted liver Couinaud segments (20). However, the liver watershed (or sub-segment) staining via the hepatic artery has not been explored in that study. ...
... In addition, DEB-TACE with smaller caliber beads (100-300 μm vs. 300-500 μm) has been considered to be more effective with higher chance of smaller particles to reach more distal locations without increasing complication rates [16][17][18][19]. Hence, given that our findings were related to comparison of 300-500 μm DEB with much smaller DSMs, the superior efficacy of DSMs-TACE over DEB-TACE may also be related to the difference in particle size and warrant further studies with comparable particle sizes. ...
... Similar controversial results regarding ADC mean in the prediction of HCC with MVI were reported by two studies stating that ADC mean is significantly lower in HCCs with MVI than in HCCs without MVI [37,38]. However, another three studies reported no significant differences between HCCs with MVI and HCCs without MVI [39][40][41]. To date, no standardized ADC measuring method has been available for liver DWI study. ...
... Other articles (n=29) were excluded for different reasons: mean ADC values or standard deviation not reported, no associations between ADC and treatment analyzed or other analyses than DWI were performed. Finally, six studies were eligible for the present meta-analysis [28][29][30][31][32][33]. The following data were used from the literature: authors, year of publication, number of patients, reported ADC values of HCC in responders and nonresponders. ...
... But, the information about lncRNAs and TNBC is quite limited and the countenance outline, roles and biological machinery regarding lncRNAs in TNBC need to be extensively investigated (Kapusta and Feschotte, 2014;Wang et al., 2017). Cancer has had a broad impact on society, it is important to recognize effective and robust tools that could change the impact of cancer (Kaushik and Sahi, 2017;Kaliamurthi et al., 2018;Kaushik et al., 2018Kaushik et al., , 2019aKaushik et al., 2020a,b,c,d). ...
... Similar discussions as presented in a paper (Wang and Xu 2017) confirm that the technique holds great promises for being used as a non invasive technique for treating neurodegenerative diseases like Alzheimer's, by targeting the specific problem areas and spots. Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice has also been reported [67] [68]. However, these studies do not confirm the effectiveness of the method and there are various limitations of the same that have been identified by experts. ...
... TP53 is a tumor-suppressor gene that regulates the cell cycle. The p53 protein that is encoded by TP53 is a transcription factor that induces cell cycle arrest and apoptosis, and it is a genomic stabilizer and an inhibitor of angiogenesis (Roberts and Paraoan 2020;Wei et al. 2019;Magni et al. 2018). H. pylori (NCTC 11,637) infection has been shown to cause mutations in the TP53 gene, and mutations in this gene represent the most common driver mutations in GC tissues. ...
... To do this, we used ARFI elastography, which has been demonstrated being a reliable technique for fibrosis evaluation and follow-up in CHC patients. [13][14][15] In line with previous studies, DAAs therapy was successful to improve hepatic stiffness and other correlated parameters such as liver enzymes, platelets count and APRI. 2,[10][11][12][13][14][15] Intriguingly, also the TC and LDL cholesterol, which showed a direct correlation with baseline stiffness, significantly increased at SVR24. ...