Chuanbo Ding’s research while affiliated with China Academy of Traditional Chinese Medicine and other places

... [11,19,30] It can promote osteogenic differentiation through the PI3K/AKT and MAPK signaling pathways. [31] Further evaluation of osteogenesis-related proteins by immunofluorescence staining also revealed that the LIP@SrTiO 3 group had the highest positive areas for OCN ( Figure 6h) and OPN (Figure 6i). ...

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Amino Acid Functionalized SrTiO3 Nanoarrays with Enhanced Osseointegration Through Programmed Rapid Biofilm Elimination and Angiogenesis Controlled by NIR‐Driven Gas Therapy

... These results demonstrate the efficacy of the PTH hydrogel in promoting wound healing and its ability to reduce oxidative stress. 98 Category 2: optimizing diabetic wound healing-targeted therapies for angiogenesis, collagen deposition, and inflammation management Targeted therapies that promote angiogenesis, collagen deposition, and reduce inflammation have emerged as promising strategies to enhance diabetic wound healing. In addressing these pivotal elements, researchers endeavor to enhance the outcomes of diabetic foot ulcers and alleviate the complexities linked to hindered wound recovery in individuals with diabetes. ...

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Recent Advances in Sodium Alginate-Based ‎Dressings for Targeted Drug Delivery in ‎Diabetic Wound Healing

... ○ Thin film hydration [ 221,[237][238][239] ○ Reverse phase evaporation [ 221,237,240] ○ Ethanol injection [ 221,237,241] ○ Detergent removal [ 221,237] • Active or remote loading (after liposome formation): ...

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Propelling Minimally Invasive Tissue Regeneration With Next‐Era Injectable Pre‐Formed Scaffolds

... Abscisic acid, as a natural plant hormone existing in a variety of plant and animal tissues, has significant pharmacological activities, including anti-inflammatory effects, which can alleviate the occurrence and development of various diseases [30,[174][175][176][177][178]. In addition, studies have shown that ABA can improve and delay aging by enhancing antioxidant activity, anti-apoptosis, and regulating intestinal flora [179]. ...

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Function and Mechanism of Abscisic Acid on Microglia-Induced Neuroinflammation in Parkinson’s Disease

... Insulin hydrogel dressing showed therapeutic effects in diabetic in vivo model with complete thickness wounds by reducing the duration of inflammation, promoting tissue granulation, encouraging the adhesion of collagen, hastening in neovascularization and epithelialization and possibly improving peripheral neuropathy. Hence, the insulin hydrogel has promising potential in wound dressings for improving DFU [74,75]. ...

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Nanoengineered Tools in the Treatment of Diabetic Wounds: a Review on Next-Generation Multidimensional Therapeutic Approaches

... [87,125] For example, shikonin encapsulated with liposome exerts a highly effective antibacterial activity against MRSA and enhances the healing power of infected burn wounds via disrupting the cell membrane integrity and physiological conditions of S. aureus. [126] In a recent study it is reported that shikonin loaded with sodium alginate/polyvinyl alcohol nanofibers (SPS) potently heals the wound in in-vitro and in-vivo diabetic models. The underlying mechanism is this SPS lowers the inflammation, enhances the deposition of collagen, and suppresses the signaling axis of IκBα/NF-κB and upsurges the expression of growth factors that helps in wound healing of diabetic models. ...

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Bioavailability and Pharmacological Properties of Shikonin‐ A Phytocompound from Lithospermum Erythrorhizon

... Among the numerous materials employed in the eld of drug delivery, hydrogels have attracted considerable attention owing to their biodegradability, biocompatibility, and non-toxicity. 1 The pH value of the human body tends to vary in different tissues and organs. For example, the stomach presents an acidic environment, while the pH of the intestine is close to neutral. 2 Some responsive hydrogels can respond to changes in pH, temperature, and ions, 3,4 and precisely, this property can be exploited to design an acid-sensitive hydrogel so that the drug it carries will be released most in the therapeutic site, thus exerting therapeutic effects. ...

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A pH-responsive dual-network biopolysaccharide hydrogel with enhanced self-healing and controlled drug release properties

... Scientists are investigating the potential of using miRNAs in blood or cerebrospinal fluid to diagnose FTD more accurately. Studies have identified several miRNAs that may be useful for distinguishing FTD from AD and other conditions (Deol et al., 2024;Ding et al., 2024). ...

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Scientific investigation of non-coding RNAs in mitochondrial epigenetic and aging disorders: Current nanoengineered approaches for their therapeutic improvement

... The most employed compound with calcium hydroxyapatite was chitosan [2,12,19,32,35,36], a polymer that stimulates wound healing and improves hemostasis by promoting collagen synthesis by fibroblasts (Figure 4). This substance, with anti-hemorrhagic and antimicrobial properties [54][55][56], increases the stability of the growth factor in grafts. The combination of chitosan and hydroxyapatite appears promising but requires more long-term clinical studies to validate its efficacy and safety [57] (Figure 4). ...

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Calcium Hydroxyapatite in Its Different Forms in Skin Tissue Repair: A Literature Review

... The DPPH results show that GGNPs have significant (p < 0.05) free radical neutralization capacity compared to GG, suggesting improved antioxidant defences and potential benefits for diabetic wound healing [12,50]. This enhanced activity is likely due to the hydroxyl groups in guar gum and the increased surface area of nanoparticles [46,47,[51][52][53][54]. The ABTS assay results confirm that GGNPs are more effective at scavenging ABTS radicals than GG, likely due to hydroxyl groups donating hydrogen atoms to ABTS radicals, enhancing antioxidant defences and aiding diabetic wound healing [55][56][57][58][59]. ...

Reference:

Antioxidant, In Vitro Cytotoxicity, and Anti-diabetic Attributes of a Drug-Free Guar Gum Nanoformulation as a Novel Candidate for Diabetic Wound Healing