Christopher Gabel's research while affiliated with Boston University and other places

... Firstly, because axon r e g e n e r a t i o n i s a h i g h l y e n e r g ydemanding process, the transfer of monocarboxylates from denervated SCs into proximal regenerating axon stumps could support axonal mitochondrial respiration and ATP production requisite for axon elongation (Figure 2a). Indeed, these energetic features combined with the striking mitochondrial redistribution into growing proximal axon stumps, have been identified as key determinants for successful axon regeneration (Cartoni et al., 2016;Han et al., 2016;Zhou et al., 2016). Secondly, the glial shuttling of energetic substrates into proximal axon stumps is expected to support neuronal survival and fitness through the ATP-dependent retrograde transport of neurotrophin-containing signaling endosomes. ...

... However, there are potential caveats in expressing stable FPs in vivo and using them to analyze engulfment. Accumulating stable FPs may be toxic to the neurons expressing them and consequently kill or alter the physiology of these neurons 25,26 leading to interpretations that might not accurately reflect engulfment of endogenous synaptic proteins. Additionally, analysis of engulfment of pH-stable FPs may obscure temporal aspects of this biology, as these proteins can survive for many hours or days in the endo-lysosomal compartment 27 . ...

... Noteworthy is that a high level of mitochondrial density is the premise of axonal regeneration [61]. In adult retinal ganglion cells, the expression of Aemcx1 (a mitochondrial protein) enhanced mitochondrial transport and promoted axonal regeneration [84]. Meanwhile, in the dorsal root ganglia neurons of mice, axonal regeneration was inhibited by blocking mitochondrial transports [85]. ...

... Knockdown of Porf-2 accelerates axon growth and growth cone formation in retinal explants Because the formation of axon growth cones is a key step in the initiation of axonal regeneration [24][25][26], we next evaluated whether Porf-2 is involved in this process. We employed an ex vivo explant culture system. ...

... This review will provide an overview of the current knowledge of myosin genes in C. elegans and discuss the potential use of this model organism to study the role of myosin motors in human disease. [25][26][27] 3 [28][29][30] 4 [30][31][32] 5 [24,25] 6 [33] 7 [25,27,34] 8 [25,34,35] 9 [36,37] 10 [38] 11 [26,34,39] 12 [34,40,41] 13 [26,34,42,43] 14 [24,34,42,44] 15 [34,40]. (B) Schematic of tissue distribution in C. elegans. ...