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July 1995
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42 Reads
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19 Citations
Nineteen individual hexalobines (diprenyl-substituted indoles) were isolated from petroleum ether and dichloromethane extracts of the stem bark of Hexalobus crispiflorus and H. monopetalus, respectively. The structures were established by spectroscopic methods. The absolute configurations result from chiroptical measurements and from chemical interconversions. Various hexalobines exhibit significant antifungal activity.
March 1993
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29 Reads
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27 Citations
Phytochemistry
Two new C-benzylated dihydrochalcones, triuvaretin and isotriuvaretin, and the known compounds uvaretin, isouvaretin, diuvaretin and angoluvarin have been isolated from an ethanolic extract of the root bark of Uvaria leptocladon. Their structures were established by spectroscopic methods, particularly homo- and heteronuclear 2D-NMR.
December 1990
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42 Reads
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31 Citations
Phytochemistry
Two new prenylated chalcones, schefflerin and isoschefflerin, were isolated from the petrol fraction of the ethanol extract of the stem bark of Uvaria scheffieri, in addition to D: B-friedoolean-5-en-3β-ol (= glutin-5-en-3β-ol), 3-farnesylindole, 2′-hydroxy-3′,4′,6′-trimethoxychalcone, 2′,6′-dihydroxy-3′,4′-dimethoxychalcone, β-sitosterol and benzyl benzoate.
... & Diels, is known to have one of the widest distribution for the African Annonaceae, being located from the West to the East of Africa (Botermans et al., 2011), and has been used in the respective countries of origin for the treatment of various ailments including fungal skin infections (Bouquet and Debray, 1974), gastric ulcers (Kerharo and Adam, 1964), sexually transmitted infections (Kayode and Kayode, 2008), inflammatory disorders (Akah and Nwambie, 1994) and as a wound healing agent (Arnold and Gulumian, 1984). Previous phytochemical investigation on the genus Hexalobus revealed the presence of mainly prenylated indole (hexalobines) and nor-aporphinoid alkaloids (Achenbach et al., 1995; Malebo et al., 2014). The prenylated indole alkaloids have been identified as the most common metabolites of the genus and some have been found to be bioactive (Achenbach et al., 1995; Achenbach and Löwel, 1995; Makangara et al., 2004). ...
July 1995
... In the present investigation, the bioassay-and 1 H NMR-guided fractionation of the stem bark EtOAc extract of F. latifolium var. ovoideum led to the isolation, structural characterization, and biological evaluation of four new Diels−Alder chalconemyrcene adducts, (+)-and (−)-ecarlottone (1), (±)-fislatifolione (5), (±)-isofislatifolione (6), and (±)-fislatifolic acid (7), and the known desmethoxyyangonin (2), didymocarpin-A (3), and dehydrodidymocarpin-A (4). Their structures were elucidated based on NMR and HRMS data, and the absolute configurations of compounds (+)-1 and (−)-1 were assigned by comparison of experimental and computed ECD spectra. ...
December 1990
Phytochemistry
... The crude MeOH extract of the stem barks of U. tortilis was sequentially partitioned using hexane and ethyl acetate to provide the corresponding sub-extracts. These sub-extracts individually fractioned using various chromatographic techniques resulted in the isolation of the new C-benzyl derivative, uvriatortilisin (1), together with the six known compounds: dichamanetin (2) [11], chamanetin (5) [12], uvaretin (6) [13], (-)-epicatechin (7) [14], β-sitosterol (3) and stigmasterol (4) [15] (Figure 1). The structures of the isolated compounds were elucidated by spectroscopic techniques including UV, IR, NMR and MS analysis. ...
March 1993
Phytochemistry
