Christian M Madsen's research while affiliated with IT University of Copenhagen and other places

... Heterozygous familial hypercholesterolaemia (HeFH), an autosomal semi-dominant genetic disorder that 3 affects approximately 1 in 300 persons or over 30 million people worldwide, is characterized by elevated 4 low-density lipoprotein cholesterol (LDL-C) levels from birth, and if untreated, is associated with 5 premature cardiovascular morbidity and mortality from accelerated atherosclerotic cardiovascular 6 disease (ASCVD) 1,2 . The condition results from dysfunctional variants in genes responsible for the 7 clearance of LDL-C. ...

... Although HDL-C has been traditionally viewed as protective in ASCVD risk, many recent observational studies performed across independent cohorts have noted that very high HDL-C is associated with higher incident ASCVD and mortality (16,17,(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(92)(93)(94) (Table 4). ...

... In this study, by analyzing the relationship between the comorbidities and prognosis of ICU sepsis patients, it was found that previous cardiovascular disease was a related risk factor for death in sepsis patients. This conclusion is consistent with Wu et al, [24] Ho et al, [25] and Sinning et al [26] Trinder et al [27] believed that high-density lipoprotein cholesterol is a major risk factor for cardiovascular disease, and inhibition of cholesteryl ester transfer protein can maintain high-density lipoprotein cholesterol levels and improve outcomes in patients with sepsis. The effect of comorbid cardiovascular disease on the prognosis of sepsis patients may be related to pathophysiological mechanisms such as inflammatory response burst, hemodynamic disturbance, and accelerated atherosclerosis. ...

... Following an update in 2018, the most recent version of DaPCaR includes a population of 153,373 unique men with a histological assessment of the prostate from 1995 to 2016. So far, this registry has resulted in several publications describing different epidemiological aspects of prostate cancer diagnosis and outcomes [4][5][6][7][8][9][10][11][12][13]. The two versions of DaPCaR were laborious to use as most data had to be manually imputed with no regular updates. ...

... Genetic variants (LPL, APOA5, APOC3, ANGPTL3, and ANGPTL4) associated with increased plasma TG levels increase the risk of acute pancreatitis [74]. Jung et al. [21] demonstrated that ANGPTL4 accelerates the pathological exacerbation of acute pancreatitis by inducing alveolar cell damage and releasing large amounts of inflammatory cytokines. ...

... Heterozygous familial hypercholesterolaemia (HeFH), an autosomal semi-dominant genetic disorder that affects approximately 1 in 300 persons or over 30 million people worldwide, is characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels from birth and, if untreated, is associated with premature cardiovascular morbidity and mortality from accelerated atherosclerotic cardiovascular disease (ASCVD). 1,2 The condition results from dysfunctional variants in genes responsible for the clearance of LDL-C. This is mainly due to loss-of-function variants in the low-density lipoprotein receptor gene (LDLR) and less commonly the apolipoprotein B gene (APOB) ...

... Mounting evidence indicated that RC promoted coronary atherosclerosis, coronary artery calcium(CAC) progression, atherosclerotic cardiovascular disease (ASCVD) and even led to cardiovascular death. 7,9,[40][41][42][43][44] . Regrettably, in our study, no association was found between RC and Gensini score, which represented the severity of the coronary lesion. ...

... [4] Patients with hyperthyroidism in the pre-operative period were shown to have an increased risk of post-operative complications. Rapacki et al. [5] claimed that serum thyroid-stimulating hormone (TSH) level was associated with mortality. However, the effect of only the TSH value was evaluated, but the mortality relationship between hypothyroid, hyperthyroid and euthyroid patients' groups were not evaluated. ...

... Recognized metabolic risk factors for acute pancreatitis are obesity, dyslipidemia, and diabetes mellitus [5][6][7][8][9][10][11][12]. Several meta-analyses have shown that obesity, as one of the most important negative prognostic factors of acute pancreatitis, increases the risk of development, correlates with the severity, development of local and systemic complications of the disease [5][6][7]. ...

... In contrast to the results of the above studies on PCSK9 inhibitors, which showed that modest decreases of plasma Lp(a) levels are associated with reductions of ASCVD risk, a Mendelian randomization analysis demonstrated that in order to achieve an ASCVD risk reduction by 20%, as that observed with LDL-cholesterol lowering by 38.67 mg/dL, a 101.5 mg/dL Lp(a) reduction is required [42]. Subsequent analyses using a similar methodology demonstrated that the Lp(a) reduction in order to achieve a 20% ASCVD risk reduction, should be 65.7 mg/dL [43] or 50 mg/dL [44]. It is noted that the above studies evaluated populations in the "primary prevention" state, and therefore their relevance to outcome trials of secondary prevention is not strong enough. ...