Ching-Feng Huang's research while affiliated with Tzu Chi University and other places

Publications (52)

Article
Background: In children, fruit and vegetable allergies are often overlooked compared with well-known allergies such as those to eggs, milk, and shellfish. Therefore, this study aimed to analyze fruit and vegetable allergies in children, including prevalence, types of food allergens, clinical presentation, management, and associated comorbid atopic...
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The number of people living with dementia globally is increasing rapidly, and there is no effective therapy. Dietary pattern is one important risk factor for the development and progression of dementia. We undertake this study to determine whether Taiwanese vegetarian diet in midlife affects dementia incidence in later years in a prospective cohort...
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Mounting evidence demonstrates that a high-salt diet (HSD) not only affects hemodynamic changes but also disrupts immune homeostasis. The T helper 17 (Th17) and regulatory T cells (Tregs) are susceptible to hypersalinity. However, research on the influence of sodium on Th2-mediated food allergies remains scarce. We aimed to investigate the effect o...
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Background Non‐alcoholic fatty liver disease (NAFLD) is the leading cause of pediatric chronic liver disease, which is highly associated with obesity. Transient elastography together with anthropometric values including waist‐to‐height ratio (WHtR) and body mass index (BMI) z‐score prove to be a more precise diagnostic method of NAFLD than ultrason...
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Background: An increasing number of studies suggest the importance of prospective memory (ProM) due to its functional relevance and sensitivity to neuropathology. However, its relevant neural substrates have not been sufficiently explored. Objectives: The present study aimed to investigate the relationship between structural connectivity and bot...
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Objective: To compare visual attention performances and diffusion tensor imaging (DTI) between subjects with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), and to discover neuronal substrates related to visual attention performances. Methods: Thirty-nine subjects with SCD and 15 with MCI, diagnosed following neuropsychologi...
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Objective: Dietary magnesium may be associated with a lower risk of dementia, however, the impact of magnesium oxide (MgO), a common laxative, on dementia has yet to be elucidated. This study aimed to investigate the association between the usage of MgO and the risk of developing dementia. Methods: We used a dataset from the National Health Rese...
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Background The causes of behavioral and psychological symptoms of dementia (BPSD) vary according to the dementia subtype and associated neuropathology. The present study aimed to (i) compare BPSD between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer’s disease (AD) across stages, and (ii) explore the associations with diff...
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Background: Painful procedures are unavoidable in the medical care of preterm babies. The unpleasant experience during the neonatal period may contribute to hyperalgesia and poor neurodevelopment outcome later. Seeking effective interventions to reduce pain are strongly indicated for these very small premature babies. The aim of this study is to i...
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The relationship between hyperinsulinemia and decreased sex hormone-binding globulin (SHBG) levels has been observed in obese adults and children. Weight reduction not only increased insulin sensitivity but also elevated serum SHBG levels in obese adults and children. However, the correlation between the changes in insulin resistance indices and se...
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Objective To describe and compare diffusion tensor imaging (DTI) parameters between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer’s disease (AD) diagnosed using structuralized neuropsychiatric assessments, and investigate potential neuronal substrates related to cognitive performance. Methods Thirty-five patients with SI...
Data
Correlation between Fazekas scale and diffusion tensor imaging parameters. ***:p <0.001; **:p <0.01; *:p <0.05. Data presented as Spearman’s rank correlation coefficient. AD: Alzheimer’s disease; SIVD: Subcortical ischemic vascular disease; FA: fractional anisotropy; MD: mean diffusivity; Rt: Right; Lt: Left. (DOC)
Article
Background: Prominent executive dysfunction can differentiate vascular dementia from Alzheimer disease (AD). However, it is unclear whether the Frontal Assessment Battery (FAB) screening tool can differentiate subcortical ischemic vascular disease (SIVD) from AD at the pre-dementia stage. In addition, the neural correlates of FAB performance have...
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Inflammation, endothelial dysfunction, and mineral bone disease are critical factors contributing to morbidity and mortality in hemodialysis (HD) patients. Physical exercise alleviates inflammation and increases bone density. Here, we investigated the effects of intradialytic aerobic cycling exercise on HD patients. Forty end-stage renal disease pa...
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Background Cobalamin (Cbl) deficiency has been associated with various neuropsychiatric symptoms of different severities. While some studies dedicated in structural neuroimaging credibly address negative impact of low Cbl status, functional imaging reports are limited. We herein retrospectively review the correlation of Tc-99 m ethyl cysteinate dim...
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Objectives: Vitamin B12 is essential for the integrity of the central nervous system. However, performances in different cognitive domains relevant to vitamin B12 deficiency remain to be detailed. To date, there have been limited studies that examined the relationships between cognitions and structural neuroimaging in a single cohort of low-vitami...
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Background: Idiopathic membranous nephropathy (MN) is an autoimmune-mediated glomerulonephritis and a common cause of nephrotic syndrome in adults. There are limited available treatments for MN. We assessed the efficacy of resveratrol (RSV) therapy for treatment of MN in a murine model of this disease. Methods: Murine MN was experimentally induc...
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The efficacy and safety of maternal tenofovir disoproxil fumarate (TDF) in reducing mother-to-infant hepatitis B virus (HBV) transmissions is not clearly understood. We conducted a prospective, multi-center trial, enrolled 118 hepatitis B surface and e antigen (HBsAg, HBeAg)-positive pregnant women with HBV DNA ≥7.5 log10 IU/mL. The mothers receive...
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A feature of allergic airway disease is the observed increase of nitric oxide (NO) in exhaled breath. Gram-negative bacterial infections have also been linked with asthma exacerbations. However, the role of NO in asthma exacerbations with gram-negative bacterial infections is still unclear. In this study, we examined the role of NO in lipopolysacch...
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Increasing studies suggest the importance of including prospective memory measures in clinical evaluation of dementia due to its sensitivity and functional relevance. The Prospective and Retrospective Memory Questionnaire (PRQM) is originally a self-rated memory inventory that offers a direct comparison between prospective and episodic memory. Howe...
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Accumulating evidence shows that subjective cognitive decline (SCD) without impairment on conventional neuropsychological tests may indicate increased risk for Alzheimer disease. Previous studies of mild cognitive impairment have demonstrated the potential role of prospective memory (PM) in the early detection of cognitive decline. We thus aimed to...
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Background Little is known about the characteristics of patients who visit the emergency department (ED) due to food allergy in Taiwan. This study aims to assess the triggers, clinical presentations, and management of patients presenting to a tertiary ED for food allergy. Methods This is a retrospective study of 369 visits presenting to the ED of...
Article
Background: Allergic rhinitis is one of the most common atopic disorders in children. There is no available method to prevent airway sensitization in newborns except allergen avoidance. Recombinant DNA plasmids encoding allergens have been proven to activate Th1 but attenuate Th2-deviated allergic responses in adult animal studies. However, their...
Article
Allergic disorders have increased substantially in recent years. Asthma is characterized by airway damage and remodeling. Reprogramming induced pluripotent stem cells (iPSCs) from adult somatic cells transfected by Oct-4/Sox-2/Klf-4, but not c-Myc, has shown the potential of embryonic-like cells. These cells have potential for multilineage differen...
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Asthma is characterized by airway hyperresponsiveness and remodeling. Pravastatin and atorvastatin are used clinically as cholesterol-lowering agents but also exhibit anti-inflammatory and immunomodulating properties. To investigate the therapeutic effect of oral statins on airway hyperresponsiveness and allergic reaction. BALB/c mice received intr...
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IgA and IgM antibodies play important roles to protect infants in early life To study the effects of breast milk feeding versus formula feeding in early infancy on the development of serum IgA and IgM. A group of 220 healthy infants born after uncomplicated pregnancies and deliveries were enrolled. The infants were divided into three groups accordi...
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Aim: Food allergy is common in children and adults, and could be potentially fatal in minor groups. It is important for physicians to identify the prevalence of food allergies and to recognise common food allergens to make precise diagnosis and choose correct therapeutic approaches. Methods: We used a nationwide, cross-sectional, random question...
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DNA vaccines encoding allergens have been developed to prevent or to treat specific IgE responses. To evaluate the potential preventive and therapeutic effect of DNA vaccines encoding Cyn d 1 alone or combined with different adjuvants on specific allergies. Recombinant plasmid Cyn d 1 (pCyn d 1) was constructed by insertion of Cyn d 1 cDNA into the...
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Membranous nephropathy (MN) is an autoimmune-mediated glomerulonephritis. The roles of effector cells and immunoglobulins (Igs) in the mediation of glomerular injury in MN have not been fully elucidated. MN was induced by cationic bovine serum albumin (cBSA), and passive disease was induced by transferring effector cells or serum into severe combin...
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Huang C-F, Wu T-C, Wu C-C, Lee C-C, Lo W-T, Hwang K-S, Hsu M-L, Peng H-J. Sublingual vaccination with sonicated Salmonella proteins and mucosal adjuvant induces mucosal and systemic immunity and protects mice from lethal enteritis. APMIS 2011; 119: 468–78. Salmonella enteritidis is one of the most common pathogens of enteritis. Most experimental va...
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Skin infection and/or nasal carriage of Staphylococcus aureus in children with atopic dermatitis (AD) is a risk factor for exacerbating disease or subsequent recurrent S. aureus infection. The purpose of the study is to evaluate the antibiotic susceptibilities of S. aureus strains from AD children and determine the most appropriate choice of antibi...
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Human milk-borne nucleotides and their related metabolic products have been reported to have important physiological roles in breast-fed infants. The purpose of this study was to measure the concentrations of free nucleotides and nucleosides in human milk from Taiwanese women. A total of 24 individual milk specimens were collected from women in Tai...
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Membranous glomerulonephropathy (MN) is the most prevalent cause of nephrotic syndrome in adult humans. However, the specific biomarkers of MN have not been fully elucidated. We examined the alterations in gene expression associated with the development of MN. Murine MN was induced by cationic bovine serum albumin (cBSA). After full-blown MN, cDNA...
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Staphylococcus aureus is an important cause of infection, particularly in persons colonized with this organism. This study compared the annual prevalence and microbiological characteristics of methicillin-resistant S. aureus (MRSA) nasal colonization in Taiwanese children from 2004 through 2009. Risk factors for MRSA were determined for the overall...
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Both erythropoietin (EPO) and haem oxygenase-1 (HO-1), an anti-oxidative stress protein, have proven protective roles in experimental autoimmune encephalomyelitis (EAE), a reliable animal model of multiple sclerosis. In this study, EPO delivered intraperitoneally could reduce disease severity in myelin oligodendrocyte glycoprotein (MOG)–EAE mice. T...
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We describe a patient who presented with unilateral paresthesia after acute isolated infarct of the splenium. A 74-year-old woman presented with acute onset of right sided numbness and tingling. MR imaging of the brain showed hypointensity on T1-weighted images and on apparent diffusion coefficient maps, and hyperintensity on T2-weighted and on dif...
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We describe a patient who presented with unilateral objective pulsatile tinnitus (PT) from an unusual spontaneous fistula between the internal carotid artery (ICA) and the internal jugular vein (IJV). The 56-year-old woman presented with unilateral PT without antecedent trauma. A blowing bruit, synchronous with the pulse, was audible with stethosco...
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An isolated prolonged episode of transient amnesia can be a major manifestation of transient global amnesia (TGA) and transient epileptic amnesia (TEA). We report a case of transient amnesia associated with a left temporal tumor and try to elucidate the possible mechanism of the amnesia. A 67-year-old right-handed man with the past history of migra...
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Salmonella enteritidis is one of the most common enteric pathogens that cause acute gastroenteritis. A vaccine that can induce systemic and mucosal immune responses by a simple, noninvasive pathway and provide protection against this mucosal pathogen is needed. Newborn BALB/c mice were sublingually vaccinated daily for the first 3 days with sonicat...
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Sublingual immunotherapy has been recently used for allergic diseases, but its mechanisms are still unclear. To examine the effect of sublingual administration of a native or denatured allergen alone or plus adjuvant on systemic T(H)2 responses and mucosal immunity in mice. Naive or sensitized BALB/c mice were sublingually vaccinated biweekly for 3...
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Thirty-six neonates were randomly assigned to 2 groups of 18 neonates each. In the pacifier group, infants were given a pacifier before milk feeding. Newborns in the control group were fed without preprandial use of a pacifier. Doppler measurement of peak systolic velocity, end-diastolic velocity, and Pourcelot resistance index in the superior mese...
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A 61-year-old man developed transient anterograde amnesia after waking from a nap. Vomiting, slow response and queer behaviors followed. A cerebral MRI showed a left caudate head hemorrhage and a SPECT showed hypoperfusion at left frontal, temporal, parietal, and basal ganglion regions. The verbal memory impairment persisted at one-month follow-up,...

Citations

... One possible explanation is that Taiwanese diets (in spite of being vegetarian or nonvegetarian) are similar to traditional diets of Asian countries, consuming more rice, soybeans, wheat, and vegetables, as opposed to the flesh foods and dairy products (cheese) typical of Western countries [31]. Thus, religious vegetarians and nonvegetarians in Taiwan essentially stayed on similar dietary habits, except that religious vegetarians were completely devoid of consuming flesh foods for religious precepts (vegetarianism) [2,54]. Additionally, our findings seem to echo a 3-year cohort study in older Japanese adults, reporting that gait speed was not associated with any type of dietary patterns (e.g., Mediterranean-and Japanese-style diets) [52]. ...
... These effects were dependent on NFAT5 and SGK1. 65 Consistently, an HSD augmented Th2 responses in food allergy mice, 136 while the high-salt formulation of Al(OH) 3 enhanced the ovalbumin (OVA)induced Th2 response in mice. 109 In addition, high NaCl can significantly increase the polarization of human Tfh cells. ...
... Elastography is becoming an imaging modality that is gaining favor and is increasingly used in evaluating and monitoring hepatic fibrosis in children. 15 In summary, disorders of the gastrointestinal system are common in children, and as a general pediatrician, I am often the first point of contact for children presenting with these disorders. The task of identifying the child with the organic or more serious disease out of the large number of children with non-organic or self-limiting illness can be daunting but consideration of a broad differential diagnosis and recognition of "red-flag" symptoms can be helpful. ...
... A recent magnetoencephalography study [32] showed that theta oscillations, which were considered pivotal to working memory and memory integration, were associated with PM performance not only over lateral brain areas but also overlapping areas of the DMN. Studies of structural connectivity also showed that PM was associated with microstructural integrity in cingulum [33,34] and superior longitudinal fasciculus [35]; these white matter bundles were found to be correlated with FC of the DMN [36]. To the best of our knowledge, this is the first study to directly examine the relationship between PM and FC in the DMN. ...
... In another study, Matar et al (24) studied the effect of oral 10% glucose on procedural pain associated with nasopharyngeal suctioning and venipuncture and found that neonates with placebo group cried signi cantly more after the procedures. In a study in preterm babies, pain score was similar in breast milk and 10% dextrose groups (25). In our study, babies in 10% dextrose group showed similar NIPS scores. ...
... Further, the McKhann group suggested neuropsychological tests that are now considered routine tests in dementia (e.g., Boston Naming Test and free recall), as well as others that are not (e.g., Brown-Peterson distractor test, continuous performance test) but which could, due to their demanding nature, be early cognitive markers of impending dementia. 43 These different early viewpoints are still seen in the difference in how current dementia guidelines and diagnostic criteria consider the importance of neuropsychology. A thorough review of clinical dementia guidelines is beyond the scope of this paper, but a few points will be highlighted. ...
... Therefore, pathological changes often occur in the corpus callosum, even when ischemia or hypoxia is mild. Previous studies reported that the strongest associations between abnormal DTI parameters and cognitive decline were in the corpus callosum and corona radiata (14,(37)(38)(39)(40)(41). In our study, we also found that abnormalities of the corpus callosum and DKI parameters were strongly represented. ...
... Some studies have investigated the associations between dietary intake or serum levels of calcium (Ca) and magnesium (Mg), but not their potential interaction, and risk for cognitive decline and dementia but generated inconsistent results. [2][3][4][5][6] The Ca:Mg dietary intake ratio has been found to modify the association between intakes of Mg and Ca in relation to multiple diseases (e.g., colorectal neoplasia) in US and Western populations with high Ca:Mg ratios (i.e., more intake of dairy products than vegetables, fruits, and seeds). [7][8][9][10] In a recent precision-based double-blinded randomized trial, among those who consumed diets with high Ca:Mg ratios, reducing Ca:Mg ratios significantly improved cognition among individuals >65 years. ...
... Widespread microstructural white matter (WM) alterations, in particular higher fractional anisotropy (FA) and lower mean diffusivity (MD), have also been reported to be associated with apathy presence and severity in people with amnestic MCI and AD dementia. These associations emerged more commonly in the cingulum [37,38], especially the anterior section close to the ACC [39][40][41], the superior longitudinal fasciculus and contiguous parietal WM areas [37,40,42,43], the corpus callosum [37,[42][43][44], the anterior thalamic radiations and the uncinate fasciculus [37,38,40,42]. These findings appear to be far more heterogeneous than those from functional connectivity studies, but they are in line with the observation that patients with AD and evidence of WM damage (e.g., hyperintensities) are more likely to present with apathy [45,46]. ...
... Dentre os métodos não farmacológicos utilizados, primordialmente por enfermeiros e técnicos de enfermagem do local de coleta de dados, 103 neonatos (55,98%) utilizaram o contato pele a pele como alternativa, 82 (44,57%) utilizaram amamentação para alívio do processo doloroso, 69 (37,5%) utilizaram a sucção não nutritiva como intervenção e 57 (30,98%) utilizaram a solução de glicose. (19) Os métodos não farmacológicos foram utilizados principalmente pela equipe de enfermagem, com 122 (63,3%) neonatos atendidos. Esse tipo de método é responsabilidade da equipe multiprofissional, com foco na equipe de enfermagem, centrando o cuidado na família, não só no neonato. ...