November 2014
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33 Reads
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8 Citations
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November 2014
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33 Reads
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8 Citations
March 2013
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1,890 Reads
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1 Citation
Dermatologica Sinica
Erythema induratum (EI) is clinically characterized by recurrent crops of tender nodules on the lower legs and lobular panniculitis with granulomatous inflammation and pathologically characterized by vasculitis and focal fat necrosis. Currently, many authors consider EI to be a multifactorial disorder with diverse causes, including Mycobacterium tuberculosis and hepatitis C infection. Here, we report a case of a 65-year-old female with a 1-year history of recurrent crops of tender nodules and plaques on her bilateral lower legs. In addition, she had suffered from a chronic cough with sputum for 1 year and had contact history with pulmonary nontuberculous mycobacterial infection from her husband. The histopathological findings of the skin biopsies were consistent with the diagnosis of EI. Chest computed tomography revealed multiple lymphadenopathy and two sets of sputum cultures showed M. abscessus. After 2 months of anti-nontuberculous mycobacterial therapy with ciprofloxacin, the skin lesions resolved completely and there was no recurrence within the following year.
... Alkylating agents chlorambucil and melphalan are the first line agents and retrospective studies have suggested their efficacy with or without corticosteroids [86][87][88]. High-dose dexamethasone and intravenous immunoglobulin can also be beneficial for NXG [89][90][91][92][93]. Lenalidomide, dapsone, and plasmapheresis are reserved for refractory cases [94][95][96]. ...
November 2014
... In Taiwan, the most frequently reported pathogenic NTM are Mycobacterium avium-intracellulare complex, rapidly growing mycobacteria (Mycobacterium chelonae, Mycobacterium fortuitum, and M. abscessus), and Mycobacterium kansasii. 3,4 M. abscessus can cause a variety of clinical diseases, including skin infection, keratitis, soft-tissue infection, pulmonary infection, and osteomyelitis. It usually follows penetrating trauma in the skin and soft-tissue infection and usually occurs in immunocompetent individuals. ...
March 2013
Dermatologica Sinica