Chien-Hsun Li's research while affiliated with Kaohsiung Medical University and other places

Publications (12)

Article
Background: Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of larger anterograde and milder retrograde amnesia that lasts up to 24 h. Objectives: We aimed to investigate the long-term risk of dementia up to 8 years in subjects with TGA. Method: We conducted a control cohort study using the Taiwan Nation...
Article
Aim: We investigated the long-term risk of dementia for up to 10 years in patients with stroke and broadened the correlates. Methods: We carried out a case-control study using the Taiwan National Health Insurance Research database in 2000 with a sampled population of 1 million. The study cohort comprised 8236 patients with stroke and no dementia...
Article
Objectives The objectives of this study were to investigate the primary diagnoses and outcomes of emergency department visits in older people with dementia and to compare these parameters with those in older adults without dementia. Design and Setting This hospital-based retrospective study retrieved patient records from a hospital research databa...
Article
Introduction Rivastigmine is a cholinesterase inhibitor, approved for the treatment of mild-to-moderate dementia of Alzheimer’s type. This study assessed the short- and long-term effectiveness and safety of rivastigmine in patients with mild-to-moderate Alzheimer’s disease (AD) in a real-world clinical setting in Taiwan. Methods This was a 48-week...
Article
Full-text available
Purposes To investigate the prevalence of pain-related diagnoses in patients with dementia and evaluate the association of pain-related diagnoses with demographic characteristics and dementia subtypes. Patients and methods In this population-based retrospective cohort study, participants were recruited from a cohort of 2 million people randomly sa...
Article
Full-text available
Music therapy (MT) reviews have found beneficial effects on behaviors and social interaction in Alzheimer's disease (AD) but inconsistent effects on cognition. The purpose of the study was to evaluate the adjunct effect of long-term and home-based MT in AD patients under pharmacological treatment. Mild AD cases (clinical dementia rating =0.5~1) wer...
Article
Full-text available
The antiphospholipid syndrome (APS) is a rare form of autoimmune coagulopathy. In this syndrome, the most common neurologic abnormality is transient ischemic attack. This can be easily overlooked if a patient presents with progressive neuropsychiatric disorders, such as depression or dementia. We report two cases of young women, aged 35 and 22 year...
Article
Background: Donepezil has been approved, and higher dosages are recommended for the treatment of Alzheimer disease (AD). However, a few studies have reported different cognitive responses in patients with AD treated with donepezil without measuring the concentration. Methods: We evaluated the relationships between the therapeutic responses and p...
Article
Full-text available
In the era of thrombolytic therapy for hyperacute ischemic stroke, most investigators have focused their attention on the factors influencing mortality and functional outcomes in patients treated with thrombolysis, but very few have focused on these factors among patients not receiving thrombolysis. The aim of this study was to investigate the prog...
Article
Full-text available
Seizures and focal neurologic deficits may be the complications of neurosyphilis, but status epilepticus as a presenting picture of neurosyphilis is rare. We describe a 41-year-old man with an acute onset of expressive dysphasia, followed by persistent seizure state and severe complications of systemic medical problems. An extensive laboratory eval...

Citations

... In this regard, of practical relevance to patients is the question as to whether TGA presdisposes to the future development of cognitive impairment or dementia. While a population-based study of 221 patients with a mean followup of 12 years found no difference in outcomes including manifestation of mild cognitive impairment or dementia [1], TGA patients were found to be at an increased risk for developing dementia in another study with 181 patients followed up over a period of 8 years [10], in which, however, patients were selected on the basis of ICD diagnoses from an insurance database, which may have hampered diagnostic precision-an issue of potential relevance to case reports or small case series predating the formulation of diagnostic criteria. ...
... Combined measurement of these imaging metrics can be used as a comprehensive neuroimaging marker for predicting vascular cognitive impairment [16][17][18][19]. However, the use of biomarkers for the diagnosis and prognosis of PSCI remains a challenge [20,21]. ...
... Older adults visit emergency departments more often than younger people [1]. However, people with dementia [1,2] visit emergency departments less frequently than the general older population [2]. Common etiologies for emergency department visits (EDVs) among patients with or without dementia are similar, including pneumonia, urinary tract infections, injuries or falls, congestive heart failure, cardiovascular disease, cerebrovascular disease, delirium, and pain [1,[3][4][5][6]. ...
... Taiwan has one of the fastest growing aging populations in the world, and the percentage of people aged C 65 years increased from 4.1% in 1980 to 10.7% in 2010 [2]. In a nationwide survey conducted from 2011 to 2012 in Taiwan, the prevalence of all-cause dementia in patients aged C 65 years was 8.04% [3], and the number of people with dementia was projected to increase to up to 210,000 by 2020 [4]. ...
... The study by Lin et al. showed that 49.07% of elderly people with dementia had experienced pain at least once and that the three most common types of pain reported in these patients' included osteoarthritis, headache, and osteoporosis (23). In the study of Takenoshita et al., the prevalence of dementia in patients with a disability was 13.9% for old group (24). ...
... Institutional Review Board Statement: The study was approved by the region Review Board in accordance with Declaration of Helsinki. approved code: (2020) Scientific Research Express Review (11), date: 29 June 2020. ...
... Распространенность и структура ПР у больных АФС недостаточно изучены, информация по данному вопросу представлена в основном в виде описания частных клинических случаев, небольших исследований или исследований, в которых использовались лишь опросники для определения проявлений ПР. В литературе имеются описания шизофрении [6], биполярного аффективного расстройства (БАР) [7], психоза [8][9][10][11] (в том числе у детей [8,12]), кататонии [11], мании [13], депрессии [14] у пациентов с АФС. По результатам исследования M. Sadetski и соавт. ...
... There was a lack of concentration-response association for donepezil for any of the CERAD subtests, although donepezil blood levels were influenced by CYP2D6 gene dose and metabolic profile (Ortner et al., 2020). In a small study by Yang, a higher concentration of donepezil was correlated only to an improvement in the long-term memory domain of the Cognitive Abilities Screening Instrument (Yang et al., 2013). ...
... The patient in this report was diagnosed with the meningovascular subtype of neurosyphilis, and IV PcG was effective. Although the incidence of symptomatic seizures in neurosyphilis has been reported to range from 14% to 60%, patients rarely develop status epilepticus (Ances et al., 2004;Li et al., 2006;Kumari et al., 2015). Seizures most commonly occur with the meningovascular form of neurosyphilis and can appear at any stage of infection (Sinha et al., 2008), as in our patient. ...
... Stroke is currently the second most common cause of death worldwide 1 and also one of the top four causes of death in Taiwan. 2 The mortality rate for inpatients with stroke has been estimated to be 17.8%, 3 and the 10-year survival rate 54.2%. 4 Stroke often leads to bio-physiological and mental distress, and poor quality of life (QOL). For example, stroke causes autonomic dysfunction 5,6 and deterioration in cardiovascular responses, 7 while post-stroke fatigue also affects 16-78% of stroke survivors. ...