Chetwyn C. H. Chan’s research while affiliated with Education University of Hong Kong and other places

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Publications (248)


A network analysis of rumination on loneliness and the relationship with depression
  • Article
  • Full-text available

December 2024

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37 Reads

Nature Mental Health

Jingyi Luo

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Tatia M. C. Lee
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Design and Implementation of an IoT Acoustic-Controlled Pillow for Sleep Health Monitoring

September 2024

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19 Reads

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1 Citation

IEEE Sensors Letters

This letter introduces an IoT acoustic-controlled pillow to reduce environmental noise, monitor snoring, and mitigate insomnia symptoms for enhancing sleep quality. The pillow offers a comprehensive sleep solution by integrating digital hardware active noise control technology with an IoT snore tracker. The acoustic control component employs cost-effective digital circuits tailored for effective noise cancellation and music playback functionality, unlike systems using digital signal processors or field-programmable gate arrays. The IoT snore tracker component utilizes mel frequency cepstral coefficients for precise snore detection, further supported by the capability to upload audio data for further analysis. This dual-functional design not only addresses environmental noise and mitigates insomnia symptoms effectively but also actively monitors snore-related disturbances. Comparative analysis underscores its affordability and practicality, positioning it as a favorable choice for consumers in noisy environments to aid relaxation and sleep induction.


Principle of superposition in the ANC operation.
ANC measurement setup in an anechoic chamber.
Commercial hybrid ANC circuit block diagram.
Circuit diagram of the proposed tunable ANC circuit (one side).
Measured result of Δt: Blue curve is with the headset and red curve is without headset.

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Tunable active noise control circuit topology for multiple-feature applications

August 2024

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65 Reads

A tunable active-noise-control (ANC) circuit topology for headsets used in different applications is presented in this article. In the current consumer headset market, ANC is a mature technology that is commonly applied to wireless headsets connected to smartphones for listening to music and making phone calls. The development of ANC headsets has resulted in low-cost and simple devices due to the built-in ANC registers in the digital circuit. Digital circuit implementation is important to provide ultra-low latency processing for different algorithms compared with using digital signal processors (DSPs). However, a limitation associated with these built-in ANC filters is that the ANC digital circuit has been designed only for the wireless headset consumer market. Consequently, ANC headsets can only be used for designated features. ANC tuned for planes by eliminating low-frequency engine noise has been commonly used in the past twenty years. Pass-through (PT) amplification is also commonly tuned to allow users to hear external sounds and have conversations without having to remove their headset. In addition, ANC and PT amplification are also not allowed to operate simultaneously on the existing chipsets. In this paper, an ANC circuit topology with ultra-low latency processing is presented, where the ANC response of the headset can be tuned without any restriction imposed by the built-in ANC filters. The proposed ANC circuit topology consists of a commercial ANC chipset with an external audio codec to provide tunable characteristics. It is achieved by fixed maximum noise cancellation of ANC chipset being modified by summing with the signal from audio-codec path via an audio mixer. Acoustic performance for several headset applications implemented using the proposed circuit is validated. This simple circuit topology can be easily developed and adapted to the current headset consumer market for consumer-selective ANC in different environments.


Theta burst stimulation on the fronto-cerebellar connective network promotes cognitive processing speed in the simple cognitive task

July 2024

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17 Reads

Background The fronto-cerebellar functional network has been proposed to subserve cognitive processing speed. This study aims to elucidate how the long-range frontal-to-cerebellar effective connectivity contributes to faster speed. Methods In total, 60 healthy participants were randomly allocated to three five-daily sessions of transcranial magnetic stimulation conditions, namely intermittent theta-burst stimulation (iTBS, excitatory), continuous theta-burst stimulation (CTBS, inhibitory), or a sham condition. The sites of the stimulations were the right pre-supplementary motor area (RpSMA), medial cerebellar vermis VI (MCV6), and vertex, respectively. Performances in two reaction time tasks were recorded at different time points. Results Post-stimulation speeds revealed marginal decreases in the simple but not complex task. Nevertheless, participants in the excitatory RpSMA and inhibitory MCV6 conditions showed direct and negative path effects on faster speeds compared to the sham condition in the simple reaction time (SRT) task (β = −0.320, p = 0.045 and β = −0.414, p = 0.007, respectively). These path effects were not observed in the SDMT task. Discussion RpSMA and MCV6 were involved in promoting the path effects of faster reaction times on simple cognitive task. This study offers further evidence to support their roles within the long-range frontal-to-cerebellar connectivity subserving cognitive processing speed. The enhancement effects, however, are likely limited to simple rather than complex mental operations.



Tracking and predicting the treatment adherence of patients under rehabilitation: a three-wave longitudinal validation study for the Rehabilitation Adherence Inventory

April 2024

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48 Reads

This study aimed to develop and validate a new measurement tool, the Rehabilitation Adherence Inventory (RAI), to measure patients’ rehabilitation adherence. We recruited 236 patients with anterior cruciate ligament (ACL) ruptures from the United Kingdom (Mage = 33.58 ± 10.03, range = 18 to 59; female = 46.2%). Participants completed a survey, that measured their rehabilitation adherence, rehabilitation volume, psychological needs support, autonomous motivation, and intention at baseline, and at the 2nd and 4th month. Factorial, convergent, discriminant, concurrent, predictive, ecological validity and test–retest reliability of the RAI were tested via exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and structural equation modelling (SEM). All the EFAs, CFAs, and SEMs yielded acceptable to excellent goodness-of-fit, χ2 = 10.51 to 224.12, df = 9 to 161, CFI > 0.95, TLI > 0.95, RMSEA <0.09 [90%C I < 0.06 to 0.12], SRMR <0.04. Results fully supported the RAI’s factorial, convergent, discriminant, and ecological validity, and test–retest reliability. The concurrent and predictive validity of the RAI was only partially supported because the RAI scores at baseline was positively associated with rehabilitation frequency at all time points (r = 0.34 to 0.38, p < 0.001), but its corresponding associations with rehabilitation duration were not statistically significant (p = 0.07 to 0.93). Overall, our findings suggest that this six-item RAI is a reliable and valid tool for evaluating patients’ rehabilitation adherence.



FIGURE 1
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Accuracy rate of performing audiovisual integration tasks in [A], [V], and [AV] conditions in both younger and older groups.
Multisensory integration augmenting motor processes among older adults

December 2023

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88 Reads

Frontiers in Aging Neuroscience

Objective Multisensory integration enhances sensory processing in older adults. This study aimed to investigate how the sensory enhancement would modulate the motor related process in healthy older adults. Method Thirty-one older adults (12 males, mean age 67.7 years) and 29 younger adults as controls (16 males, mean age 24.9 years) participated in this study. Participants were asked to discriminate spatial information embedded in the unisensory (visual or audial) and multisensory (audiovisual) conditions. The responses made by the movements of the left and right wrists corresponding to the spatial information were registered with specially designed pads. The electroencephalogram (EEG) marker was the event-related super-additive P2 in the frontal-central region, the stimulus-locked lateralized readiness potentials (s-LRP) and response-locked lateralized readiness potentials (r-LRP). Results Older participants showed significantly faster and more accurate responses than controls in the multisensory condition than in the unisensory conditions. Both groups had significantly less negative-going s-LRP amplitudes elicited at the central sites in the between-condition contrasts. However, only the older group showed significantly less negative-going, centrally distributed r-LRP amplitudes. More importantly, only the r-LRP amplitude in the audiovisual condition significantly predicted behavioral performance. Conclusion Audiovisual integration enhances reaction time, which associates with modulated motor related processes among the older participants. The super-additive effects modulate both the motor preparation and generation processes. Interestingly, only the modulated motor generation process contributes to faster reaction time. As such effects were observed in older but not younger participants, multisensory integration likely augments motor functions in those with age-related neurodegeneration.


Identification of the human cerebral cortical hemodynamic response to passive whole-body movements using near-infrared spectroscopy

December 2023

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106 Reads

The human vestibular system is crucial for motion perception, balance control, and various higher cognitive functions. Exploring how the cerebral cortex responds to vestibular signals is not only valuable for a better understanding of how the vestibular system participates in cognitive and motor functions but also clinically significant in diagnosing central vestibular disorders. Near-infrared spectroscopy (NIRS) provides a portable and non-invasive brain imaging technology to monitor cortical hemodynamics under physical motion. Objective This study aimed to investigate the cerebral cortical response to naturalistic vestibular stimulation induced by real physical motion and to validate the vestibular cerebral cortex previously identified using alternative vestibular stimulation. Approach Functional NIRS data were collected from 12 right-handed subjects when they were sitting in a motion platform that generated three types of whole-body passive translational motion (circular, lateral, and fore-and-aft). Main results The study found that different cortical regions were activated by the three types of motion. The cortical response was more widespread under circular motion in two dimensions compared to lateral and fore-and-aft motions in one dimensions. Overall, the identified regions were consistent with the cortical areas found to be activated in previous brain imaging studies. Significance The results provide new evidence of brain selectivity to different types of motion and validate previous findings on the vestibular cerebral cortex.


Citations (61)


... Numerous studies indicate that residential [23], school [24,25], work [26] and public buildings [27] frequently fail to meet the needs of neurodivergent individuals. While some issues can be mitigated by passive devices, such as those designed to reduce unexpected noise in public spaces [28] or provide sensory refuges [29], extensive research demonstrates that designing spaces with inclusive indoor comfort in mind can enhance productivity and comfort for everyone [30]. ...

Reference:

Inclusive Indoor Comfort of neurodivergent individuals diagnosed before adulthood: a comprehensive study on thermal, acoustic, visual and air quality domains
Healthcare headset with tuneable auditory characteristics control for children with Autism spectrum disorder
  • Citing Article
  • March 2024

Applied Acoustics

... In recent years, a paradigm shift has emerged in the approach to addressing functional dependence among Stroke survivors, guided by the International Classification of Functioning, Disability, and Health (ICF) framework [12,13]. This approach emphasizes the importance of focusing on enhancing functionality and participation rather than solely addressing issues related to body structure and function [14]. ...

International Classification of Functioning, Disability, and Health-based rehabilitation program promotes activity and participation of post-stroke patients

... Globalization, driven by the widespread use of social media and internet access, has brought the world closer together, transforming it into a global village [1][2][3]. This digital system has made high school and university students' learning and life easier, but the excessive use of the internet and social media may also cause mental, academic, and other health-related problems [4][5][6]. Globally, the number of Internet users climbed from 414 million in 2000 to 665 million in 2002, and by 31 December 2019, it had surpassed 4.574 billion [7]. Internet addiction is now becoming a major mental health issue among university and college students. ...

Influences of Lifestyle Profiles and Problematic Internet Use on Mental Distress in University Students
  • Citing Article
  • November 2023

Psychological Studies

... Still, many scientific papers investigated speech and language abilities in high-functioning children with ASD who were previously diagnosed with Asperger's syndrome (AS) or high-functioning autism (HFA). Moreover, in literature, the term high-functioning autism (HFA) often overlaps with the term Asperger's syndrome (AS) (Mazzone et al., 2012) or they are used interchangeably (e.g., Colle, Baron-Cohen, Wheelwright, & van der Lely, 2008;Freitag, Kleser, Schneider, & von Gontard, 2007;Lee, Liang, Hou, Tse, & Chan, 2023). Unlike classic autism, individuals with HFA/AS are described as having language and cognitive abilities within the limits of typical development (Bishop, 2003;Freitag et al., 2007;Gibson, Adams, Lockton, & Green, 2013;Shriberg et al., 2001), although some studies reported language impairments in some cases of HFA (Dai, He, Chen, & Yin, 2022). ...

The Chinese “Reading the Mind in the Eyes” Test: A Study with Normal Adults, and Adults with Asperger Syndrome/High-functioning Autism

Asian Journal of Psychiatry

... The regions with functional dysconnectivity do not spatially overlap with those with structural degeneration [11]. In addition, most of the above studies adopted a singlemodality path, that is, structural or functional, which limits the interpretability of the brain-to-performance correspondence [12]. ...

Effects of computerized cognitive training on structure‒function coupling and topology of multiple brain networks in people with mild cognitive impairment: a randomized controlled trial

Alzheimer's Research & Therapy

... Therefore, it is crucial to emphasize the importance of person-centered approaches in Physical Therapy (PT) interventions to help individuals maximize health, well-being, functionality, quality of life, and participation [16,17]. Person-centered interventions, which focus on functional and meaningful goals, are essential for improving performance. ...

Goal-setting and personalization under the International Classification of Functioning, Disability, and Health framework: Community reintegration program for post-stroke patients

Frontiers in Rehabilitation Sciences

... Overall, our results suggest lower lobular volumes across middle age and older adulthood. The volumetric differences are likely due to underlying cellular differences with cerebellar aging, characterized by decreases in granule and Purkinje cells with total cerebellar white matter decreasing 25.9% (Andersen et al. 2003;Arleo et al. 2023;Iskusnykh et al. 2024). ...

Consensus Paper: Cerebellum and Ageing

The Cerebellum

... In contrast, the positive distractor effect is mediated by the mPFC (Chau et al., 2014;Fouragnan et al., 2019). Interestingly, the same or adjacent interconnected mPFC regions have also been linked to the mechanisms by which representational elements are integrated into new representations (Barron et al., 2013;Klein-Flügge et al., 2022;Law et al., 2023;Papageorgiou et al., 2017;Schwartenbeck et al., 2023). In a number of situations, such as multi-attribute decision making, understanding social relations, and abstract knowledge, the mPFC achieves this by using a spatial map representation characterised by a grid-like response (Constantinescu et al., 2016;Bongioanni et al., 2021;Park et al., 2021) and disrupting mPFC leads to the evaluation of composite choice options as linear functions of their components (Bongioanni et al., 2021). ...

Frontopolar cortex represents complex features and decision value during choice between environments
  • Citing Article
  • May 2023

Cell Reports

... These findings, coupled with the distinct deficit patterns of the PCC/PCu observed in our results, suggest that there are naturally different homogeneous groups within schizophrenia with distinct psychopathological underpinnings. Moreover, the PCC/PCu is a major hub of default mode network engaged in the monitoring of internal processes, episodic, working, and visuospatial memory [76]. Given the crucial role of the PCC in working memory, the volumetric loss observed in this study may serve as a neurobiological mechanism underlying executive dysfunction in schizophrenia. ...

Computerized Cognitive Training Enhances Episodic Memory by Down-Modulating Posterior Cingulate-Precuneus Connectivity in Older Persons With Mild Cognitive Impairment: A Randomized Controlled Trial
  • Citing Article
  • April 2023

American Journal of Geriatric Psychiatry

... Our results suggest that the average controllability, and redundancy, of edges within the frontoparietal network could be important for enabling the diverse cognitive functions relevant in processing speed and other similar tasks. Furthermore, we found that processing speed was positively associated with redundancy in the dorsal attention (DorsAttnA), visual (VisCent), salience/ventral attention (SalVentAttnB) and limbic (LimbicB) networks, suggesting that increased number of communication pathways involving each of these networks could support guidance of top-down attention and discrimination in this visually-based processing speed task [79][80][81][82] . ...

Causal influences of salience/cerebellar networks on dorsal attention network subserved age-related cognitive slowing

GeroScience