Chester H. Conrad's research while affiliated with Boston University and other places

... This augmentation is transient, and at some point, the hypertrophied noninfarcted myocardium fails. An initial preliminary report showed minimal changes in muscle function and no changes in muscle stiffness 3 weeks after large infarction ( Bing et al., 1983). ...

... titin isoform (Krüger et al. 2009). A greater density of collagen is also present in the SHR and is thought to contribute to the impaired cardiac function observed in this animal strain compared to control (Conrad et al. 1990). In the SHR, the amounts of both endomysial and perimysial collagen increase with age, and there is a greater density of collagen compared to age-matched WKY controls (LeGrice et al. 2012). ...

... Survival and Remodeling After MI in AT 1A Null Mice 2095 hypertrophy and pleural effusion. 23 The RV weight (RVW)/ body weight (BW) ratio was significantly larger in infarcted mice than in sham-operated mice at 1 week after MI. There were no significant differences in the RVW/BW ratio and the lung weight/BW ratio between WT mice and KO mice at 1 week after MI. ...

... A study may generate health data that should be incorporated into a patient's electronic health record (EHR), 1 or a study may seek to populate an electronic data collection form automatically from health data in the EHR. 1,2 To address this, various solutions have been proposed. [3][4][5][6][7][8][9][10][11] Broadly speaking, solutions can be classified into 3 approaches: 1) Bring clinical data into a research platform; 2) Bring research data into a clinical platform (eg, EHR); or 3) Bring both clinical and research data into a third analytics platform. ...

... Un interesante ejemplo fue el trabajo realizado por Fiore et al. Este trabajo abierto randomizado estudió dos regímenes de insulina (según una tabla estándar o ajustado al peso del paciente) y comparó el tiempo de estadía hospitalaria en pacientes que requerían correcciones con insulina 20 . El trabajo aprovechó la historia clínica electrónica de los centros participantes. ...

... Since it was reported that these fibrotic changes in LV were associated w diastolic cardiac failure [19], it is suggested that human omentin-1 may prevent the di tolic dysfunction of LV, perhaps through decreasing LV fibrosis. The activation of tra forming growth factor (TGF) pathway was considered as one of the mechanisms for fibrosis in LV from SHR [20]. Since human omentin-1 was reported to inhibit the T pathway [21], human omentin-1 administration may ameliorate the fibrosis in LV fr SHR, perhaps through inhibiting the TGF pathway. ...

... 10 SHR show compensated cardiac hypertrophy at 9 months 11 and develop diastolic and severe systolic dysfunction between 12 and 20 months. [11][12][13] Note that clinical symptoms defining HF (shortness of breath, fatigue and weakness, and edema) are difficult to document in animals. Therefore, we are not using the term HF when describing results for SHR. ...

... The animals were also monitored for only 60 days postpartum, which may be sufficient to observe short-and medium-term cardiac changes, but not long-term changes. It could also be possible that differences in cardiac physiology would be more apparent in the presence of a stressor (e.g., isoproterenol-induced myocardial injury) (Brooks and Conrad, 2009;Krenek et al., 2009). ...

... In vivo investigations have reported that, although hypoxia at high altitudes does not induce changes in TSH levels, the serum levels of T3 and T4 increase [10,11]. Furthermore, studies using rat models of hypoxia exposure reported an increase in the levels of type 3 iodothyronine deiodinase, which converts T4 to the inactive 3,3,5′-triiodo-l-thyronine [12,13]. However, very little is known about the pituitary-thyroid endocrinological changes that accompany hypoxic ischemia in humans. ...

... 46 Despite its similarity to L-hArg, several previous cardiovascular studies on the long-term effects of L-arginine supplementation failed to prevent cardiac remodeling and heart failure. [47][48][49][50][51][52] NO exerts well-investigated cardioprotective effects and takes part in the regulation and maintenance of cell viability, endothelial function, and vascular homeostasis. 53 However, the importance of L-hArg as a direct substrate for NO synthase has been questioned considering its lower catalytic efficiency and the approximately 20 times lower concentrations in biological fluids and tissue (plasma concentration of approximately 2 μmol/L) compared to L-arginine (plasma levels of 100-250 μmol/L). ...