Charline Miot's research while affiliated with University of Angers and other places

... [91] Pathological studies found that when the plaque ruptures, a large number of macrophages, thinning fibrous caps, and proliferating new blood vessels could be observed in the lesion site of the criminal; at the same time, the number of T cells also reaches a peak. [92,93] This suggests that T cells and macrophages play an important role in the rupture process of late-stage AS plaques. ...

... A combined modality of concurrent chemoradiotherapy based on platinum regimen is the main approach for locally advanced NPC, showing an improvement in overall survival, although there is a relatively high chance of recurrence in non-metastatic NPC [11][12][13][14][15][16]. Given the strong relation between EBV infection and NPC, plasma EBV DNA detection has been used for screening among susceptible population helping the diagnosis at earlier stages [17][18][19]. ...

... Similar to IL-22, IL-26 is another emerging pro-inflammatory member of IL-10 cytokine family, which could be produced by macrophages, NK and NKT cells as well as T cells, especially Th17 cells [18,61]. IL-26 was reported to be closely related to autoimmune disease as well as microbial defense process due to the specific structure [61]. ...

... In this study, more than half of the patients suffered from acute GvHD, which was similar to the proportion seen in NEMO-deficient patients (13/27) 32 and patients with ZAP70 deficiency (6/8). 33 Another study suggested an incidence of 33% in acute GvHD among IPEX syndrome patients. ...

... Interestingly, the patient showed a close to the normal frequency of SHM in memory B cells (17). Moreover, two other siblings with CR2 mutation showed decreased levels of class-switched memory B cells and low to normal IgG (18). CD21 plays a role in antigen trapping in B cell follicles (16). ...

... Meanwhile, clusterin has been implicated as a marker of fertility in stallions [19], men [42], rams [43], and bulls [13,40,43]. Clusterin is a chaperone-like protein involved in protein-to-protein interactions, lipid exchange, and membrane remodelling during maturation [49,50], and notably, facilitates apoptotic cell clearance [51,52]. Thus, the increased abundance of clusterin and ELSPbP1 in low-fertility ejaculates is most likely indicative of an increased proportion of dead or apoptotic cells. ...

... Thus, our results show that IL-34 may modulate M-CSF effects through the M-CSFR, explained in part by the formation of a heteromeric cytokine M-CSF/IL-34. In addition to the already identified functions of IL-34 and M-CSF in exacerbated macrophage activation (bowel diseases, liver fibrosis, chronic skin inflammation , arthritis, etc.), this new heteromeric cytokine M-CSF/IL-34 which may differentially regulates the activation/localization of M-CSFR strengthens the global therapeutic approaches for blocking all biological functions coming from these molecules [7,8,45464748495051. In contrast to IL-17A or IL-17F that form either disulfide-linked homodimers or heterodimers through their cysteine knot motif, M-CSFR were transfected with a vector encoding M-CSF or IL-34 or with an empty vector as control and 48 h later, M-CSFR and ERK1/ 2 phosphorylation was assessed by Western blot. ...

... We studied the dynamics of CD4 + CD31 + T-cell subset recovery in patients underwent AHSCT, i.e., under severe lymphopenic conditions. Similar to previous studies, we described a prolonged slow reconstitution of CD4 + CD45RA + CD31 + RTEs following high-dose chemotherapy with hematopoietic stem-cell transplantation [9,10,17,18]. Significant decrease of naïve CD4 + CD31 + T cells after the local mediastinal irradiation and its almost total absence in the patient underwent thymomectomy also suggested the "recent thymic" origin of this subset. Interestingly, we showed a slight depletion of RTEs in patients after local non-mediastinal RT. ...

... Furthermore, IL-26-primed monocytes induced differentiation of naïve CD4 + T cells into Th17 cells in vitro [46]. IL-26 was also shown to inhibit the production of IgA and IgG in anti-CD40-treated B cells [47] and induce the expression of inflammatory cytokines and interferons in NK cells [48] independently of the IL-26 receptor. Although these studies suggest the existence of a hitherto unidentified IL-26 receptor, it is also possible that IL-26 acts on these cells via an altogether different mechanism. ...

... Initially known as a cytokine produced by monocytes and macrophages, IL-34 can be synthesized by additional cell types, including epithelial cells, macrophages, endothelial cells, fibroblasts, neurons, hepatocytes and, and is constitutively expressed in many adult human organs, such as heart, brain, liver, spleen, thymus, testis, ovary, prostate, small intestine, and colon (12)(13)(14)(15)(16). ...