Charline Miot's research while affiliated with University of Angers and other places

Publications (20)

Article
Background & Aims Interleukin-26 (IL-26) is a proinflammatory cytokine involved in the pathophysiology of chronic inflammatory disorders. It has properties atypical for a cytokine, such as direct antibacterial activity and DNA-binding capacity. In a previous study, we observed an accumulation of IL-26 in fibrotic and inflammatory lesions in the liv...
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Epstein-Barr virus (EBV) preferentially infects epithelial cells and B lymphocytes and sometimes T and NK lymphocytes. Persistence of EBV-infected cells results in severe lymphoproliferative disorders (LPDs). Diagnosis of EBV-driven T or NK cell LPD and chronic active EBV diseases (CAEBV) is difficult, often requiring biopsies. Herein, we report a...
Article
Résumé La vaccination a pour but d’induire une réponse immunitaire mémoire capable de protéger l’hôte contre la survenue d’une maladie liée à un agent infectieux. Au-delà de cette protection individuelle, les vaccins confèrent une protection collective en limitant le risque de transmission aux sujets qui ne peuvent être vaccinés ou ne répondent pas...
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Interleukin 26 (IL-26) is the most recently identified member of the IL-20 cytokine subfamily, and is a novel mediator of inflammation overexpressed in activated or transformed T cells. Novel properties have recently been assigned to IL-26, owing to its non-conventional cationic, and amphipathic features. IL-26 binds to DNA released from damaged ce...
Article
Résumé Le diagnostic précoce des déficits immunitaires primitifs (DIP) est un élément clé pour une prise en charge adéquate des patients, afin de limiter la survenue de complications. Les manifestations cliniques et biologiques des DIP sont variées, incluant les infections récurrentes, mais aussi des manifestations oncologiques ou auto immunes. Des...
Article
Résumé La glomérulonéphrite extra-membraneuse idiopathique peut désormais être qualifiée de maladie autoimmune glomérulaire. Un certain nombre d’autoanticorps a été décrit contre des composants glomérulaires ou contre des protéines alimentaires usuelles. Certains de ces autoanticorps, tel que les anticorps anti-PLA2R et les anticorps anti-THSD7A so...
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X-linked recessive ectodermal dysplasia with immunodeficiency is a rare primary immunodeficiency caused by hypomorphic mutations of the IKBKG gene encoding the nuclear factor κB essential modulator (NEMO) protein. This condition displays enormous allelic, immunological, and clinical heterogeneity, and therapeutic decisions are difficult because NEM...
Article
The diagnosis of primary immunodeficiency diseases (PIDs) is important for the early and adaptive care of patients and their families. Among the various known PIDs, a number of them concern the innate immune system, which involve a set of cells and mechanisms involved in the host defense by a nonspecific and fast response. The majority of patients...
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Clusterin (Clu), an extracellular chaperone, exhibits characteristics of soluble innate immunity receptors, as assessed by its ability to bind some bacteria strains. In this study, we report that Clu also binds specifically to late apoptotic cells but not to live, early apoptotic, or necrotic cells. Histones, which accumulate on blebs during the ap...
Article
To the Editor: Hodgkin lymphoma (HL) is a hematologic malignancy of the lymphoid tissue that mainly affects young adults.1 Standard treatment for subdiaphragmatic stages I and II combines chemotherapy regimen followed by dose-reduced involved-field irradiation (including mediastinum). Adverse effects of treatment include early death, second neoplas...
Article
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Objective Interleukin-26 (IL-26) is a member of the IL-10 cytokine family, first discovered based on its peculiar expression by virus-transformed T cells. IL-26 is overexpressed in chronic inflammation (rheumatoid arthritis and Crohn’s disease) and induces proinflammatory cytokines by myeloid cells and some epithelial cells. We thus investigated th...
Article
Unlabelled: Chronic hepatitis C virus (HCV) infection is characterized by progressive hepatic fibrosis, a process dependent on monocyte recruitment and accumulation into the liver. The mediators expressed in chronically injured liver that control the differentiation of human monocytes into profibrotic macrophages (Mφ) remain poorly defined. We rep...

Citations

... [91] Pathological studies found that when the plaque ruptures, a large number of macrophages, thinning fibrous caps, and proliferating new blood vessels could be observed in the lesion site of the criminal; at the same time, the number of T cells also reaches a peak. [92,93] This suggests that T cells and macrophages play an important role in the rupture process of late-stage AS plaques. ...
... A combined modality of concurrent chemoradiotherapy based on platinum regimen is the main approach for locally advanced NPC, showing an improvement in overall survival, although there is a relatively high chance of recurrence in non-metastatic NPC [11][12][13][14][15][16]. Given the strong relation between EBV infection and NPC, plasma EBV DNA detection has been used for screening among susceptible population helping the diagnosis at earlier stages [17][18][19]. ...
... Similar to IL-22, IL-26 is another emerging pro-inflammatory member of IL-10 cytokine family, which could be produced by macrophages, NK and NKT cells as well as T cells, especially Th17 cells [18,61]. IL-26 was reported to be closely related to autoimmune disease as well as microbial defense process due to the specific structure [61]. ...
... In this study, more than half of the patients suffered from acute GvHD, which was similar to the proportion seen in NEMO-deficient patients (13/27) 32 and patients with ZAP70 deficiency (6/8). 33 Another study suggested an incidence of 33% in acute GvHD among IPEX syndrome patients. ...
... Interestingly, the patient showed a close to the normal frequency of SHM in memory B cells (17). Moreover, two other siblings with CR2 mutation showed decreased levels of class-switched memory B cells and low to normal IgG (18). CD21 plays a role in antigen trapping in B cell follicles (16). ...
... Meanwhile, clusterin has been implicated as a marker of fertility in stallions [19], men [42], rams [43], and bulls [13,40,43]. Clusterin is a chaperone-like protein involved in protein-to-protein interactions, lipid exchange, and membrane remodelling during maturation [49,50], and notably, facilitates apoptotic cell clearance [51,52]. Thus, the increased abundance of clusterin and ELSPbP1 in low-fertility ejaculates is most likely indicative of an increased proportion of dead or apoptotic cells. ...
... Thus, our results show that IL-34 may modulate M-CSF effects through the M-CSFR, explained in part by the formation of a heteromeric cytokine M-CSF/IL-34. In addition to the already identified functions of IL-34 and M-CSF in exacerbated macrophage activation (bowel diseases, liver fibrosis, chronic skin inflammation , arthritis, etc.), this new heteromeric cytokine M-CSF/IL-34 which may differentially regulates the activation/localization of M-CSFR strengthens the global therapeutic approaches for blocking all biological functions coming from these molecules [7,8,45464748495051. In contrast to IL-17A or IL-17F that form either disulfide-linked homodimers or heterodimers through their cysteine knot motif, M-CSFR were transfected with a vector encoding M-CSF or IL-34 or with an empty vector as control and 48 h later, M-CSFR and ERK1/ 2 phosphorylation was assessed by Western blot. ...
... We studied the dynamics of CD4 + CD31 + T-cell subset recovery in patients underwent AHSCT, i.e., under severe lymphopenic conditions. Similar to previous studies, we described a prolonged slow reconstitution of CD4 + CD45RA + CD31 + RTEs following high-dose chemotherapy with hematopoietic stem-cell transplantation [9,10,17,18]. Significant decrease of naïve CD4 + CD31 + T cells after the local mediastinal irradiation and its almost total absence in the patient underwent thymomectomy also suggested the "recent thymic" origin of this subset. Interestingly, we showed a slight depletion of RTEs in patients after local non-mediastinal RT. ...
... Furthermore, IL-26-primed monocytes induced differentiation of naïve CD4 + T cells into Th17 cells in vitro [46]. IL-26 was also shown to inhibit the production of IgA and IgG in anti-CD40-treated B cells [47] and induce the expression of inflammatory cytokines and interferons in NK cells [48] independently of the IL-26 receptor. Although these studies suggest the existence of a hitherto unidentified IL-26 receptor, it is also possible that IL-26 acts on these cells via an altogether different mechanism. ...
... Initially known as a cytokine produced by monocytes and macrophages, IL-34 can be synthesized by additional cell types, including epithelial cells, macrophages, endothelial cells, fibroblasts, neurons, hepatocytes and, and is constitutively expressed in many adult human organs, such as heart, brain, liver, spleen, thymus, testis, ovary, prostate, small intestine, and colon (12)(13)(14)(15)(16). ...