Charli Deepak Arulanandam's research while affiliated with Kaohsiung Medical University and other places

Publications (9)

Article
Full-text available
Plasticizers increase the flexibility of plastics. As environmental leachates they lead to increased water and soil pollution, as well as to serious harm to human health. This study was set out to explore various web applications to predict the toxicological properties of plasticizers. Web-based tools (e.g., BOILED-Egg, LAZAR, PROTOX-II, CarcinoPre...
Preprint
Full-text available
Inappropriate activation of the Epidermal growth factor receptor (EGFR) group of kinases has been identified in a variety of tumour cells, either due to mutation or overexpression. Although the tumour is a fatal disease, significant therapy discoveries have lately been made. The human EGFR and this family of kinases have emerged as promising target...
Preprint
Inappropriate activation of the Epidermal growth factor receptor (EGFR) group of kinases has been identified in a variety of tumour cells, either due to mutation or overexpression. Although the tumour is a fatal disease, significant therapy discoveries have lately been made. The human EGFR and this family of kinases have emerged as promising target...
Preprint
Full-text available
Sugar substitutes are mostly artificial, man-made industrial products used as additives in food and beverages. Most of these substances flow through the digestive tract and food chains to become emerging organic contaminants in various abiotic and biotic environmental media. Here, we predict the mutagenicity and carcinogenicity of commonly used sug...
Preprint
Full-text available
Phthalic acid esters (PAEs) and bisphenols are used as plasticizers worldwide. During plastic production, use, deposition, and recycling these compounds contaminate the environment and affect environmental health. In this study, we investigated the toxicity of plasticizers by using in silico tools. None of the test compounds were found to be hERG b...
Preprint
Drug discovery is an important research area to improve human health. Currently, treatment of gastrointestinal stromal tumors (GISTs) is unsuccessful due to drug-resistance, hence, there is a demand for alternatives. Often, there is limited time available for toxicological assessments and a lack of safer drugs. It is possible to identify new drugs...
Article
Carotenoids are natural pigments with substantial applications in nutraceutical, pharmaceutical, and food industries. In this study, optimization of the fermentation process for enhancement of β-carotene and biomass production by Exiguobacterium acetylicum S01 was achieved by employing statistical designs including the Placket-Burman design (PBD) a...
Article
Full-text available
Schizophrenia (SCZ) is one of the brain disorders which affects the thinking and behavioral skills of patients. This disorder comes along with an overproduction of kynurenic acid in the cerebrospinal fluid and the prefrontal cortex of SCZ patients. In this study, marine bacterial compounds were screened for their suitability as antagonists against...

Citations

... Moreover, 20% of people affected may develop chronic ciguatera poisoning, and chronic weakness may last for years [151]. Despite some efforts, there is still no antidote for any natural marine toxin [152]. Transcriptome-level studies have been devoted to studying the effects of CTXs on mice, both in vitro and in vivo, as well as on the whole blood of patients [153][154][155]. ...
... These data provide valuable resources for building some in silico models to assess the covert of skin sensitization. In addition, the skin sensitization QSAR models can be applied to not only cosmetic ingredients but also the compound, which can impact the ecosystems such as dye pollution, the effect of personal care products on aquatic species, or plasticizers (Arulanandam et al., 2021;Funar-Timofei and Ilia, 2020;Khan et al., 2020) as well as the pharmacokinetics profiles of low molecular weight oligohydroxyalkanoates (Roman et al., 2020), suggesting that the skin sensitization models has a wide range of applications. To date, most of the published skin sensitization models are qualitative predictions, viz. ...
... Some pigment stability has been affected by environmental factors [42]. The fermentation process can be optimised using Exiguobacterium acetylicum S01 to get higher biomass and betacarotene [43]. Beta-carotene production was induced by Dunaliella salina using RSM [14]. ...
... Bonactin is reported as non-carcinogenic and non-toxic to aquatic model organisms. It has been reported as a suitable natural compound for schizophrenia disorder, suggesting little or no toxicity to humans [36]. However, further research is needed to ascertain their safety for humans and the environment before using them as a potential lead component for the synthesis of agricultural fungicides for controlling wheat blast. ...