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Abstract Scientific processes are being automated via workflow technology in the bio- CAPE (Bioinformatics Collaboration Analysis Pipeline Environment) project. This aims to address eciency,issues, improve access to bioinformation anal- ysis tools, and form a framework for bioinformation data quality improve- ment. This project was focused on this last point, particularly re-execution of processes for validation, the logging and application management required and points on implementation. I have use BLAST to show how annotation provides eective,data management in both logging and re-execution process. Contents