Catherine Arnaud's research while affiliated with University of Toulouse and other places

Publications (224)

Article
Background: To evaluate the association between exposure to early skin-to-skin contact (SSC) and incidence of late-onset sepsis (LOS) in extremely and very preterm infants. Methods: Observational study using the national population-based EPIPAGE-2 cohort in 2011. A propensity score for SSC exposure was used to match infants with and without expo...
Article
Objective To identify the characteristics of early life growth associated with later overweight or obesity (OWO) in very preterm population. Design Length, weight and body mass index (BMI) were prospectively recorded from three prospective, population-based cohorts with 5 years (Loire Infant Follow-up Team (LIFT), EPIPAGE2 (Etude EPIdémiologique s...
Article
Full-text available
Aim: To determine trends and current estimates in regional and global prevalence of cerebral palsy (CP). Method: A systematic analysis of data from participating CP registers/surveillance systems and population-based prevalence studies (from birth year 1995) was performed. Quality and risk of bias were assessed for both data sources. Analyses we...
Article
Full-text available
Aim: To study the association between the socioeconomic environment of area of residence and prevalence and characteristics of children with cerebral palsy (CP). Method: Data on 8-year-old children with CP born in 2000-2011 (n = 252) were extracted from a regional population-based register in France. The European Deprivation Index (EDI), availab...
Article
Full-text available
Background While evidence concerning Quality of Life (QoL) in youth with cerebral palsy (CP) in comparison to the general population has been accumulating, there is a lack of studies exploring differences on a wider range of positive and negative mental health outcomes in emerging adults. Methods This binational case control study is part of the S...
Article
Introduction Chez les enfants prématurés, l’association entre croissance des 1000 premiers jours et surpoids dans l’enfance ou l’adolescence n’est pas claire. L’objectif est d’identifier les caractéristiques fœtales, néonatales et de croissance des 2 premières années associées avec le surpoids ou obésité (SOO) dans une population d’enfants prématur...
Article
Background The number of twin pregnancies continues to increase worldwide as both the number of pregnancies obtained by medically assisted reproduction and age at first pregnancy keep rising. Preterm delivery is their major complication. The effectiveness of preventive treatments such as progesterone or cervical cerclage for women with a short cerv...
Article
Full-text available
Background Very preterm children generally perform poorly in executive functions and particularly in working memory. Adaptive training tasks encouraging these children to work continuously on their personal working memory capacity can be very useful. Above all in preschool-age children, several cognitive training programs focused on improving worki...
Article
Full-text available
Background: After the COVID-19 pandemic reached France in January 2020, a national lockdown including school closures was officially imposed from March 17, 2020, to May 10, 2020. Pediatric intensive care units (PICUs) admit critically ill infants, children and teenagers with severe acute conditions, in particular infectious and traumatic diseases....
Article
Full-text available
Background Adolescents with idiopathic scoliosis display high ghrelin levels. As hyperghrelinemia is found in patients with PWS and early-onset scoliosis (EOS) is highly prevalent in these patients, our aims were to explore (1) whether ghrelin levels differ between those with and without EOS and correlate with scoliosis severity, and (2) whether gh...
Article
Full-text available
The aim is to conduct a pilot study to prospectively describe echocardiographic parameters in neonates with pulmonary hypertension (PH) managed according to current recommendations and to identify those parameters that could predict worsening of short-term outcomes. All neonates less than 28 days old with a diagnosis of PH were prospectively enroll...
Article
Full-text available
Introduction: While most people with cerebral palsy (CP) will have a life expectancy similar to that of the general population, international research has primarily focused on childhood and adolescence; and knowledge about the quality of life (QoL) of young adults with CP, its trajectories, and associated factors remains scarce. Methods: This longi...
Article
Children with parents suffering from a psychiatric disorder are at higher risk for developing a mental disorder themselves. This systematic review and meta-analysis of randomized controlled trials aims to evaluate the efficacy of psychosocial interventions to prevent negative mental health outcomes in the offspring of parents with mental illness. E...
Article
Aims To compare hospital-assisted neonatal home care and standard hospital care for preterm newborns on neurodevelopment at 2 years corrected age, as well as duration of hospitalization, breastmilk rates, and readmissions before 1 year. Methods This observational study enrolled 415 inborn neonates <34+ 6 weeks that received home care (2008 to 2015...
Article
Full-text available
Background Effective inclusion in society for young people with disabilities is increasingly seen as generating opportunities for self-development, and improving well-being. However, significant barriers remain in the vast majority of activities meaningful for young adults. Research argues that various personal (disabilities, health) and environmen...
Article
Full-text available
Aim: To report on prevalence of cerebral palsy (CP), severity rates, and types of brain lesions in children born preterm 2004 to 2010 by gestational age groups. Methods: Data from 12 population-based registries of the Surveillance of Cerebral Palsy in Europe network were used. Children with CP were eligible if they were born preterm (<37 weeks of g...
Article
Full-text available
Objectives: To describe neurodevelopment at age 5 among children born preterm. Design: Population based cohort study, EPIPAGE-2. Setting: France, 2011. Participants: 4441 children aged 5½ born at 24-26, 27-31, and 32-34 weeks. Main outcome measures: Severe/moderate neurodevelopmental disabilities, defined as severe/moderate cerebral palsy (Gross Mo...
Article
Background Induction of labor is among the most common procedures for pregnant women. Only a few randomized clinical trials (RCT) with relatively small samples have compared misoprostol to dinoprostone. Although their efficacy appears similar, their safety profiles have not been adequately evaluated and economic data are sparse. Objective To test...
Article
Full-text available
Objectives This study aimed to evaluate in the changes in the percentage of adolescents who brush their teeth twice a day and the association with socio-economic status and health behaviors between 2006, 2010 and 2014 among adolescents from the French cross-sectional studies of the Health Behavior in School-aged Children (HBSC) survey. Methods Our...
Article
Full-text available
Cerebral magnetic resonance imaging (MRI) is considered an important tool in the assessment of a child with cerebral palsy (CP), as it is abnormal in more than 80% of children with CP, disclosing the pathogenic pattern responsible for the neurological condition. MRI, therefore, is recommended as the first diagnostic step after medical history takin...
Article
Full-text available
Objective: To compare the short and mid-term outcomes of preterm twins by chorionicity of pregnancy. Design: Prospective nation-wide population-based EPIPAGE-2 cohort study. Setting: 546 maternity units in France, between March and December 2011. Population: A total of 1700 twin neonates born between 24-34 weeks of gestation. Methods: The...
Article
Full-text available
Multiple births (twins or higher order multiples) are increasing in developed countries and may present higher risk for cerebral palsy (CP). However, few studies can reliably investigate trends over time because these outcomes are relatively rare. Objective We pooled data from European CP registers to investigate CP birth prevalence and its trends...
Article
Aim To examine the evolution of child–parent discrepancy in reporting quality of life (QoL) between childhood and adolescence in children with cerebral palsy (CP) and to investigate potential factors associated with such a discrepancy. Method We used data from the SPARCLE (Study of PARticipation of Children with CP Living in Europe) study, a popul...
Article
Objective To assess whether chorioamnionitis is associated with cerebral palsy (CP) or death at 2 years' corrected age in infants born before 32 weeks of gestation after spontaneous birth. Study design EPIPAGE-2 is a national, prospective, population-based cohort study of children born preterm in France in 2011; recruitment periods varied by gesta...
Article
Introduction: The objective of this study was to investigate the association between planned mode of delivery and neonatal outcomes with spontaneous very preterm birth among singletons in cephalic presentation. Material and methods: Etude Epidémiologique sur les Petits Ages Gestationnels 2 is a French national, prospective, population-based coho...
Article
Aim To describe maternal employment and the socio‐economic status of the household up to 8 years after the very preterm birth of a child, according to the presence and type of motor or cognitive impairment. Method A total of 1885 families from the French EPIPAGE cohort of children who were born very preterm between 1997 and 1998 were included. Mot...
Article
Background Surveillance of cerebral palsy in Europe (SCPE) presents the first population-based results on neuroimaging findings in children with cerebral palsy (CP) using a magnetic resonance imaging classification system (MRICS). Method MRIs of children with CP born between 1999 and 2009 from 18 European countries were analyzed. MRICS identifies p...
Article
Aim The aim is to study access to intrathecal baclofen (ITB) for children with cerebral palsy (CP) in Europe, as an indicator of access to advanced care. Methods Surveys were sent to CP registers, clinical networks, and pump manufacturers. Enquiries were made about ITB treatment in children born in 1990 to 2005 by sex, CP type, level of gross motor...
Article
Objective This article describes associated impairments in children with cerebral palsy (CP) and its subtypes. Method Children born between 1990 and 2006 recorded in the Surveillance of Cerebral Palsy in Europe common database were studied. An “impairment index” characterized severity of impairments and their combinations. Results Amongst the 11,01...
Article
Full-text available
We estimated autism spectrum disorder (ASD) prevalence in 7–9 year-old children in 2015 using data from three nationwide health registry systems (Denmark, Finland, Iceland) and two French population-based regional registries. Prevalence ranged from 0.48% in South-East France to 3.13% in Iceland (South-West France: 0.73%, Finland: 0.77%, Denmark: 1....
Article
Full-text available
Background: In the last 20 years, substantial improvements have been made in the diagnosis, treatment and management of patients with Prader-Willi syndrome (PWS). Few data on causes of death are available since those improvements were made. Our study assessed the causes of death among French patients with PWS over the first 11 years of experience...
Article
Full-text available
Introduction: To evaluate the consequences of bronchopulmonary dysplasia (BPD) on academic outcomes and healthcare use in adolescents born very preterm. Methods: This cohort study included 15-year-old adolescents born very preterm (< 32 weeks) between 2011 and 2013, with and without BPD, and controls born full term. Data regarding academic perfo...
Technical Report
Full-text available
The Surveillance of Cerebral Palsy in Europe (SCPE) 20th Anniversary Scientific Report 1998-2018.
Poster
Objectifs : Le brossage des dents est le principal moyen de prévention des pathologies bucco-dentaires. Celui-ci doit être inculqué dès l’enfance pour permettre une prévention la plus précoce possible et une installation pérenne d’un bon brossage. Notre objectif est de décrire l’évolution de la fréquence de brossage des dents, ainsi que des déterm...
Article
Prematurity and bronchopulmonary dysplasia (BPD) affect long-term lung function. We studied the respiratory outcome of adolescents born very preterm and controls from the Etude EPIdémiologique sur les Petits Ages Gestationnels cohort and analysed their current lung function in relation to asthma symptoms (categorised in three age groups) from birth...
Article
Full-text available
To describe neurodevelopmental outcomes at 2 years corrected age for children born alive at 22-26, 27-31, and 32-34 weeks’ gestation in 2011, and to evaluate changes since 1997. DESIGN: Population based cohort studies, EPIPAGE and EPIPAGE-2. SETTING: France. PARTICIPANTS: 5567 neonates born alive in 2011 at 22-34 completed weeks’ gestation, with 41...
Article
Objectives: To describe tooth brushing frequency and its association with a wide range of socioeconomic and behavioral characteristics, using a nationally representative sample of school-aged children in France. Methods: Our sample included 11,337 students aged from 10 to 16 years, who answered the HBSC questionnaire. Some variables were grouped...
Article
Full-text available
Objectives: The principal aim was to investigate the feasibility of assessing mother-infant interactions at discharge and at 6 months infant corrected age in singletons born before 32 weeks of gestation. The secondary aims were to describe these interactions and their disorders, explore the association between maternal emotional state and the inte...
Article
Objectives: To investigate the efficacy of ACS therapy on short-term neonatal outcomes in preterm twins and further document the influence of the ACS-to-delivery interval. Design: EPIPAGE2 is a nationwide observational multicentre prospective cohort study of neonates born between 22 and 34 completed weeks of gestation. Setting: All French mate...
Article
Full-text available
Objectives To describe neurodevelopmental outcomes at 2 years corrected age for children born alive at 22-26, 27-31, and 32-34 weeks’ gestation in 2011, and to evaluate changes since 1997. Design Population based cohort studies, EPIPAGE and EPIPAGE-2. Setting France. Participants 5567 neonates born alive in 2011 at 22-34 completed weeks’ gestati...
Article
Aim: To evaluate the prevalence of co-occurring autism spectrum disorders (ASDs) among children with cerebral palsy (CP), and to describe their characteristics. Method: The data of 1225 CP cases from four population-based registers (Iceland, Sweden, and two in France) and one population-based surveillance programme (North East England, UK) parti...
Article
Aim: Since 2005, the French food safety agency has recommended that very preterm or low birth weight babies should be fed with pasteurised, expressed breast milk and feeding policies on this vary widely in French neonatal units. We investigated the differences between using a mother's expressed milk, in fresh or pasteurised forms, for very preterm...
Article
Aim: Parent-reporting is needed to examine Quality of Life (QoL) of children with cerebral palsy (CP) across all severities. This study examines whether QoL changes between childhood and adolescence, and what predicts adolescent QoL. Method: SPARCLE is a European cohort study of children with CP, randomly sampled from population databases. Of 81...
Article
Background and objectives: Patients with Prader-Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults. Animal data demonstrated that early treatment with OXT restores sucking after birth. Our aim is to reproduce these data in infants with PWS. Metho...
Article
Background: Intraventricular hemorrhage is a major risk factor for neurodevelopmental disabilities in preterm infants. However, few studies have investigated how pregnancy complications responsible for preterm delivery are related to intraventricular hemorrhage. Objective: We sought to investigate the association between the main causes of prete...
Article
Background and aim: Factors promoting family adaptation to child’s disability are poorly studied together. The aim of the study was to describe the family adaptation to disability and to identify determinants associated with using a global theoretical model. Materials and methods: 286 families of teenagers [13–17 years] with cerebral palsy (CP) fro...
Article
Objective: To assess the impact of latency duration on survival, survival without severe morbidity, and early-onset sepsis in infants born after preterm premature rupture of membranes (PPROM) at 24-32 weeks' gestation. Study design: This study was based on the prospective national population-based Etude Épidémiologique sur les Petits Ȃges Gestat...
Article
Introduction and objectives: Many international studies have demonstrated that delayed umbilical cord clamping reduces neonatal morbidity. However, in France, delayed umbilical cord clamping is still not performed in many neonatal units. The aims of this study were to evaluate the feasibility of developing a protocol of delayed umbilical cord clam...
Article
Mesurer la qualité de vie des personnes polyhandicapées est un enjeu majeur pour les personnes atteintes elles-mêmes, pour leurs familles et pour les professionnels qui travaillent auprès d’elles, mais pose des problèmes méthodologiques de taille aux chercheurs. Une étude a été conduite en 2011 par une équipe de chercheurs du Comité d’études, d’édu...
Article
Objectives: To describe the implementation of neurodevelopmental care for newborn preterm infants in neonatal ICUs in France in 2011, analyze changes since 2004, and investigate factors associated with practice. Design: Prospective national cohort study of all births before 32 weeks of gestation. Setting: Twenty-five French regions. Participa...
Article
Résumé But Les objectifs étaient d’estimer la concordance intra- et inter-observateurs de lecture entre deux vitesses de déroulement de papier (1 et 2 cm/min) en utilisant la classification FIGO du RCF. Matériels et méthodes Étude expérimentale monocentrique de lecture de 60 tracés de 60 minutes par six lecteurs (3 sages-femmes et 3 gynécologues...
Article
Objective: To determine whether extrauterine growth is associated with neurologic outcomes and if this association varies by prenatal growth profile. Study design: For 1493 preterms from the EPIPAGE (Étude Épidémiologique sur les Petits Âges Gestationnels [Epidemiological Study on Small Gestational Ages]) cohort, appropriate for gestational-age...
Article
We read with interest the recent meta-analysis (MA) by Blix et al.(1) reporting that intrapartum surveillance with STAN monitoring resulted in a significant decrease in metabolic acidosis at birth compared with cardiotocography (CTG) alone (OR: 0.64, 95%CI: 0.47-0.88). This finding conflicts with the Cochrane MA by Neilson et al. (2) and MA by Sacc...
Article
Background: Growth patterns of patients with Noonan syndrome (NS) were established before the involved genes were identified. Objective: The goal of the present study was to compare growth parameters according to genotype in patients with NS. Materials and methods: The study population included 420 patients (176 females and 244 males) harborin...
Article
Full-text available
Background: Medical schools aim to prepare medical students for their residency responsibilities. However, in France, there is no assessment of medical students' skills when they start their residency. Goal: The objective of this study was to assess the quality of basic life support delivered by first-year residents in pediatrics during a simula...
Article
Full-text available
Objective To determine whether breech presentation is an independent risk factor for neonatal morbidity, mortality, or long-term neurologic morbidity in very preterm infants.DesignProspective population-based cohort.PopulationSingletons infants without congenital malformations born from 27 to 32 completed weeks of gestation enrolled in France in 19...
Article
Objective: To investigate the association of the cause of preterm birth on in-hospital mortality of preterm neonates born from 24 to 34 weeks of gestation. Methods: L'Etude épidémiologique sur les petits âges gestationnels (EPIPAGE)-2 is a prospective, nationwide, population-based cohort of very preterm births. After dividing causes of preterm b...
Article
Full-text available
Background and objectives: Study of the impact of socioeconomic status on autism spectrum disorders (ASD) and severe intellectual disabilities (ID) has yielded conflicting results. Recent European studies suggested that, unlike reports from the United States, low socioeconomic status is associated with an increased risk of ASD. For intellectual di...
Article
Background: Quality of life (QOL) is an important dimension to consider in Alzheimer's disease (AD), but few large-scale studies have analyzed self and caregiver reports of patient QOL. Methods: Patient QOL was evaluated in a cohort of 574 AD patients with the QOL-AD scale over 2 years. Results: Caregiver reports of patient QOL were lower at b...
Article
Full-text available
Register-based prevalence rates of childhood autism (CA), Asperger's syndrome (AS) and other autism spectrum disorders (ASD) were calculated among children aged 7 years old of the 1997-2003 birth cohorts, living in four counties in France. The proportion of children presenting comorbidities was reported. 1123 children with ASD were recorded (M/F ra...
Article
ProblemPlatelet reactivity has not been evaluated in integrated functional testing during normal pregnancy. Here, we analysed platelet functions under arterial shear rate in comparison with static conditions.Method of studyThirty pregnant women with uncomplicated pregnancies and 30 healthy non-pregnant women were enrolled in this study. Platelet ad...
Article
Asthma in children is one of the major causes of emergency department visits. The assessment of the asthma severity and a stepwise approach to pharmacologic treatment can lead to an improved short-term outcome of the asthmatic children. After require prompt treatment, some will go home, others will require hospitalization. Clinical practice guideli...
Article
Objectives: To determine whether small head circumference (HC) or birth weight (BW) or both are associated with neonatal and long-term neurologic outcome in very preterm infants. Study design: All 2442 live births from the 1997 Epipage study between 26 and 32 weeks of gestational age in 9 regions of France were analyzed. A total of 1395 were tes...
Article
To assess the value of the prenasal thickness to nasal bone length ratio (PT/NBL) for detecting trisomy 21 (T21) after the first trimester. Two examiners blinded to fetal T21 status retrospectively measured prenasal thickness (PT) and nasal bone length (NBL) of T21 and control fetuses at 15-36 weeks' gestational age on two-dimensional images from a...
Article
Full-text available
Longitudinal studies are essential tools in medical research. In these studies, variables are not restricted to single measurements but can be seen as variable-trajectories, either single or joint. Thus, an important question concerns the identification of homogeneous patient trajectories. kml and kml3d are R packages providing an implementation of...
Article
Low socio-economic context increases the risk of preterm delivery and may affect short-term outcomes in children born preterm. We described the social context of preterm delivery in France in 2011 and compared it with the general population of deliveries over the same period. We also studied how social context influenced pregnancy and delivery char...
Article
Full-text available
Le tabagisme des jeunes est préoccupant au vu du nombre important d’individus concernés et de ses conséquences sur la santé. Nous avons étudié les liens entre le tabagisme quotidien et la famille, les pairs, l’école, l’environnement socio-économique de vie. Des régressions logistiques hiérarchiques à deux niveaux (1: les élèves, 2: les écoles) ont...