Catharina Suharti's research while affiliated with kariadi hospital and other places

Publications (11)

Article
To investigate which recent infection could have caused the present dengue-like symptoms, in adult patients clinically fulfilling the WHO criteria for dengue, in which serologically were not confirmed for dengue virus infections. Prospective study. During an outbreak of dengue (between May 1995 and May 1996) 118 consecutive adults (>13 years) suspe...
Article
To investigate the patterns of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, interferon-gamma (IFN-gamma) and interleukin-1 receptor antagonist (IL-1Ra) during the course of dengue shock syndrome. Prospective clinical study. Pediatric Intensive Care Unit, Dr. Kariadi Hospital, the university hospital of Diponegoro Uni...
Article
The mechanisms contributing to bleeding complications in dengue hemorrhagic fever were studied by investigating the pattern of activation of the coagulation and fibrinolytic systems in 50 children with severe dengue hemorrhagic fever. Thirteen patients (26%) died, and activation of coagulation was most pronounced in the deceased group. Fibrinolysis...
Article
In 50 consecutive children admitted to the intensive care unit with the clinical diagnosis of dengue hemorrhagic fever (DHF)/dengue shock syndrome (grade III or IV), 20 patients with mild DHF (grade I or II), and 20 healthy control patients, the plasma lipid profile was measured. Levels of total plasma cholesterol, high-density lipoprotein, and low...
Article
Full-text available
In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation (F1+2 and TATc) and fibrinolysis (t-PA, PAPc, and D-dimer). We found that TNF-al...
Article
The kinetics of dengue virus (DEN)-specific serum immunoglobulin classes (immunoglobulin M [IgM] and IgA) and subclasses (IgG1 to IgG4) were studied in patients suffering from dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). Serum samples from non-DEN febrile patients were included as controls. IgM, IgG1, and IgG3...
Article
A prospective cohort study was performed in 50 patients with dengue haemorrhagic fever (DHF) to determine the potential role of the contact activation system and factor XI activation (intrinsic pathway) in the coagulation disorders in DHF. To establish whether TAFI (thrombin-activatable fibrinolysis inhibitor) was involved in the severity of the co...
Article
Full-text available
Infection, both bacterial and nonbacterial, may be associated with coagulation disorders, resulting in disseminated intravascular coagulation and multiorgan failure. In the last few decades a series of in vivo and in vitro studies has provided more insight into the pathogenetic mechanisms and the role of cytokines in these processes. Because of the...
Article
Aim: to investigate which recent infection could have caused the present dengue-like symptoms, in adult patients clinically fulfilling the WHO criteria for dengue, in which serologically were not confirmed for dengue virus infections. Methods: prospective study. During an outbreak of dengue (between May 1995 and May 1996) 118 consecutive adults (>1...

Citations

... While activation of the contact pathway by bacterial infection has been described in humans and in animal models 24,37 , few studies have investigated whether this pathway is activated in viral infection 38,39 . Hyperinflammation associated with COVID-19 results in activation of innate immune cells (neutrophils and monocytes) that interact with platelets and the coagulation cascade, ultimately leading to micro-and macrothrombosis. ...
... (6.9%), influenza virus (4.6%), and leptospirosis (3.3%) [15]. The prevalence of CHIKV in our cohort (2.7%) is similar to that of southern Sri Lanka in 2007 (3%) [17], higher than similar studies in Cambodia (0.6%) [18], Thailand (1.1%) [19] or Central Java (1.7%) [20], but lower than India in 2012 (6%) [21]. Variation in case rates may be affected by different detection methods. ...
... While this enables the identification of potential lung parenchymal involvement, other causes of dyspnea, such as PE, are debarred from detection. The importance of contrast application and thus the exclusion of PE is emphasized by the fact that the current literature indicates coagulopathic disorders and a high probability of elevated D-dimer values in patients suffering from COVID-19 [18,21,[30][31][32]. ...
... Notably, this includes IgA, the second most prevalent antibody isotype in serum and one that has been suggested to play a unique and non-redundant role in many viral infections (26). Most work on DENV-reactive serum IgA has focused on its potential as a diagnostic tool (27), with a small body of literature examining DENV-reactive serum IgA as a possible correlate of severe disease (28)(29)(30)(31). ...
... The platelet normal range https://doi.org/10.29309/TPMJ/2022.29.06.6342 2 is from 150,000-450,000 platelets/μl and in many individuals it may reach <40000 thrombocytes/μl from the third to seventh day of fever. 10 Patients may need platelet infusions in order to maintain their haemostatic function at normal physiological levels in certain situations. 11,12 Platelets activation and malfunctioning are concerned in the prothrombotic consequences of Dengue shock syndrome and Dengue hemorrhagic fever, according to the reported studies by many researchers. ...
... Oxidation of HDL-c is more pronounced in older patients due to the small footprint of antioxidants [165]. Similar alterations in the lipid profile are apparent in viral and protozoan-driven sepsis as well [164,[166][167][168]. Some studies quantified quite precisely that a serum level of HDL-c below 25 mg/dL is the threshold of dramatically increased risk for Furthermore, if these conditions persist over a long period, even small deviations may lead to significant impacts [129]. ...
... High levels of PAI-1 have been associated with increased disease severity and decreased survival in other viral haemorrhagic fevers, such as Ebola virus disease and dengue. [28][29][30] The course of PAI-1 over time in patients with dengue is similar to what we observed in our Lassa fever cohort, with concentrations remaining high in patients who died but decreasing over time in those who survived. 29 High PAI-1 concentrations have also been shown to correlate with increased severity and fatal outcome in patients with acute sepsis, although its predictive capability is controversial. ...
... Literature demonstrating the importance of Rickettsia infection in the hospital setting is lacking. Previous reports were from a few serologically-confirmed patients from three cities in 1976, 1996 [28], 1997-2000 [9], 2006 [10] and may not have reached clinicians. Third, access to diagnostic tests for rickettsioses is poor and specificity is low for available rapid diagnostics for other pathogens such as S. typhi, dengue virus and Leptospira spp. ...
... DHF may ultimately lead to Dengue Shock Syndrome (DSS), which is characterized by decreased peripheral perfusion leading to tissue damage and the failure of multiple organs [2]. The event of the "cytokine storm", referring to heightened production of cytokines (Figure 4), majorly, IL-1, IL-2, IL-10, CXCL-10, CCL-2, VEGF, TNF-α, IFN-α, and IFN-γ, is observed in both conditions of DHF and DSS, which is not evident in mild/intermediate DF [81][82][83][84]. The event of the cytokine storm is a result of the imbalance between the Th1 and Th2 cytokine responses. ...