Casper Schmidt’s research while affiliated with Aalborg University and other places

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Publications (4)


The potential of infra-low frequency neurofeedback training in peak performance: The first double-blinded placebo-controlled longitudinal study in healthy adults
  • Article

April 2024

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1 Read

Journal of Psychiatric Research

Casper Schmidt

Plan for Scheduled Titration of Daily Dronabinol Dosing
Patient Demographic and Clinical Characteristics
Patient Finally Dronabinol Titrated Dosage Level and Reported Treatment Outcomes at Two-Week Follow-Up
Wechsler's Adult Intelligence Scale III Cognition Test Results at Baseline vs. Two-Week Follow-Up
Patient Rating of Pain, Fatigue, and Depressive Symptoms at Baseline vs. Two-Week Follow-Up
Impact of Low-Dose Dronabinol Therapy on Cognitive Function in Cancer Patients Receiving Palliative Care: A Case-Series Intervention Study
  • Article
  • Full-text available

December 2023

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24 Reads

Ditte Buchwald

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Casper Schmidt

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Dorte Buchwald

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[...]

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Peter Derek Christian Leutscher

Background: Cannabis may offer therapeutic benefits to patients with advanced cancer not responding adequately to conventional palliative treatment. However, tolerability is a major concern. Cognitive function is a potential adverse reaction to tetrahydrocannabinol containing regimens. The aim of this study was to test cognitive function in patients being prescribed dronabinol as an adjuvant palliative therapy. Methods: Adult patients with advanced cancer and severe related pain refractory to conventional palliative treatment were included in this case-series study. Patients were examined at baseline in conjunction with initiation of dronabinol therapy and at a two-week follow-up using three selected Wechsler's adult intelligence scale III neurocognitive tests: Processing Speed Index (PSI), Perceptual Organization Index (POI), and Working Memory Index (WMI). Patients were also assessed using pain visual analog scale, Major Depression Inventory, and Brief Fatigue Inventory. Results: Eight patients consented to take part in the study. Two patients discontinued dronabinol therapy, one due to a complaint of dizziness and another critical progression of cancer disease, respectively. The remaining six patients were successfully treated with a daily dosage of 12.5 mg dronabinol (p = 0.039). PSI (p = 0.020), POI (p = 0.034.), and WMI (p = 0.039). Conclusions: Cognitive function improved in this group of patients with advanced cancer in conjunction with low-dose dronabinol therapy. The cause is likely multifactorial including reported relief of cancer-associated symptoms. Further clinical investigation is required.

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Infra-low frequency neurofeedback training in Dravet syndrome: A case study

May 2023

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54 Reads

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3 Citations

Epilepsy & Behavior Reports

This case study examines how an intervention of infra-low frequency neurofeedback training (ILF-NFT) affects the symptomatology of an eight-year-old patient with Dravet syndrome (DS), a rare and highly disabling form of epilepsy. Our results demonstrate that ILF-NFT has improved the patient’s sleep disturbance, has significantly reduced seizure frequency and severity, and has reversed neurodevelopmental decline, with positive development in intellectual and motor skills. No significant changes have been made to the patient’s medication in the observed period of 2.5 years. Thus, we draw attention to ILF-NFT as a promising intervention in addressing DS symptomatology. Finally, we discuss the study’s methodological limitations and warrant future studies to assess the effect of ILF-NFT in DS in more elaborate research designs.


Complex PTSD: what is the clinical utility of the diagnosis?

December 2021

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250 Reads

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30 Citations

Background The diagnosis of complex posttraumatic stress disorder (CPTSD) was included in the 11th revised edition of the International Classification of Diseases (ICD-11). CPTSD shares trauma-specific symptoms with its sibling disorder PTSD but is additionally characterized by disturbances of the individual’s self-organization (DSO). The clinical utility of the CPTSD diagnosis has yet to be thoroughly investigated. Objective The current study aimed to examine the clinical utility of the CPTSD diagnosis, considering the upcoming implementation of ICD-11 in clinical practice. Method International field studies, construct- and validity analyses leading up to the inclusion in ICD-11 are reviewed, and the diagnostic measures; International Trauma Questionnaire (ITQ) and International Trauma Interview (ITI) are presented. Also, the relationship between CPTSD and borderline personality disorder (BPD) is elaborated in an independent analysis, to clarify their differences in clinical relevance to treatment. Treatment implications for CPTSD are discussed with reference to existing guidelines and clinical needs. Results The validation of ITQ and ITI contributes to the cementation of CPTSD in further clinical practice, providing qualified assessment of the construct, with intended informative value for both clinical communication and facilitation of treatment. CPTSD is found distinguishable from both PTSD and BPD in empirical studies, while the possibility of comorbid BPD/PTSD cases being better described as CPTSD is acknowledged. Practitioners need to employ well-established methods developed for PTSD, while considering additional DSO-symptoms in treatment of CPTSD. Conclusions The inclusion of CPTSD in ICD-11 may potentially facilitate access to more tailored treatment interventions, as well as contribute to increased research focus on disorders specifically associated with stress. The clinical utility value of this additional diagnosis is expected to reveal itself further after ICD-11 is implemented in clinical practice in 2022 and onwards. Yet, CPTSD’s diagnostic inclusion gives future optimism to assessing and treating complex posttraumatic stress symptoms.

Citations (2)


... A fourth reports on extended ILF training of a veteran with PTSD [59]. A remarkable recovery in a case of Dravet Syndrome by way of intensive and extensive ILF neurofeedback training has also been documented [102]. And recovery from a fifteenyear history of dysthymia in 45 sessions combining standard ILF protocols with ILF synchrony 23 training has been documented in a case report. ...

Reference:

Endogenous Neuromodulation at Infra-Low Frequency: Method and Theory
Infra-low frequency neurofeedback training in Dravet syndrome: A case study

Epilepsy & Behavior Reports

... Similar emotional-relational problems may occur in Borderline Personality Disorder (BPD), however, evidence points the premise that cPTSD qualifies as a standalone diagnostic construct apart from BPD (Cloitre et al., 2014;Cyr et al., 2021;Frost et al., 2020;Hyland et al., 2019;Knefel et al., 2016;Powers et al., 2022). This distinction is clinically important since it signalises differences in change mechanisms and brings definitional clarity around which symptoms to address (Nestgaard & Schmidt, 2021). ...

Complex PTSD: what is the clinical utility of the diagnosis?