Carsten O. Daub's research while affiliated with Karolinska Institutet and other places

... Spatial transcriptomics (ST) performs high-throughput measurement of transcriptomes in complex biological tissues at single-cell or subcellular resolution, preserving spatial information [1][2][3][4][5][6][7][8][9]. In the past decade, the rapid development of ST technologies has facilitated exciting discoveries in different domains, including neuroscience [10][11][12] and cancer research [13][14][15]. The popular ST technologies and corresponding platforms differ in terms of the procedure used to record spatial profiles, such as region of interest (ROI) selection [16,17], next-generation sequencing (NGS) with spatial barcoding [18][19][20], and single-molecule fluorescence in situ hybridization (smFISH) [21][22][23]. ...

... Similar to our results, Arner et al. [52] demonstrated that PWVAo correlated positively with subcutaneous adipocyte volume and negatively with fat cell count in patients with obesity. Weight loss could be associated with improvement in PWVAo but positive long-term results on arterial stiffness can only be achieved by bariatric surgery [53]. Regarding blood vessel wall thickness, no significant correlations with parameters of arterial stiffness were reported in our study. ...

... Direct intradermal application of IL-33 gives rise to leukocyte recruitment and skin inflammation [9]. IL-33 signals via the ST2/IL1RacP complex, a receptor abundantly expressed by MCs even in the steady state [4,[10][11][12]. As a consequence, MCs are among the most important targets of IL-33 and are considered crucial amplifiers in IL-33-induced inflammation [13][14][15][16][17]. ...