Carolyn A. Sink's research while affiliated with Virginia Tech (Virginia Polytechnic Institute and State University) and other places
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Publications (12)
Method validation studies characterize the performance of new laboratory methods relative to established methods using quality guidelines in order to define the new method's performance characteristics and to identify differences that could influence data interpretation. We investigated the performance of an in-clinic dry chemistry analyzer (Cataly...
This chapter outlines the clinical signs and the associated physiologic mechanisms of transfusion reactions for the small animal practitioner. Febrile or allergic reactions may occur in the same manner as severe hemolytic reaction. For this reason, any change in the patient's condition during blood infusion should be considered a possible sign of a...
The main goal of a blood bank or transfusion service is to provide a safe transfusion for every patient. Quality programs include quality control, quality assurance, and quality improvement, all of which ensure application of quality principles within operational areas. Examining issues related to quality assurance assist in setting high standards...
This chapter describes the most commonly used blood components in veterinary medicine. Fresh whole blood provides blood volume expansion and increased oxygen-carrying capacity to the recipient. Whole blood provides for volume expansion, increased oxygen-carrying capacity, protein source, and stable coagulation factors. Once fresh whole blood is sto...
As blood transfusions are associated with certain risks, transfusion therapy should only be initiated when laboratory pre-transfusion testing is complete and the expected benefits of the transfusion outweigh the potential risks. In dogs, universal blood type means that the donor is negative for all dog erythrocyte antigen (DEA) types. Cats should a...
Blood collection in dogs and cats necessitates careful planning to minimize potential donor reactions or contamination of the unit of blood. A tube stripper is used to push or “strip” blood from the donor tubing into the primary blood collection bag. Sealers are used to both contain the blood product and to impede contamination of the blood product...
This chapter reviews blood typing methods and provides step-by-step procedures for compatibility testing and processing blood components. The “gold standard” of blood typing for dogs is detection of blood antigens by hemagglutination following incubation with polyclonal or monoclonal antibodies, while for cats the “gold standard” is the tube or mic...
Blood donors are vital to the success of any transfusion service, and veterinary blood banks depend on qualified donors to provide the blood necessary to meet the needs of the patients they serve. Good communication is imperative to the success of any blood donor program, and it is beneficial to define and communicate owner expectations during the...
Knowledge of blood types, necessary equipment, blood type and crossmatch test procedures, and test interpretation are paramount in effective and safe transfusion medicine. A blood type and, in some instances, a crossmatch test should be performed prior to packed RBC (pRBC) or whole blood (WB) transfusions in dogs and cats. Blood typing and crossmat...
This study evaluated the quality and bacteriologic safety of platelet-rich plasma (PRP) produced by 3 simple, inexpensive tube centrifugation methods and a commercial system. Citrated equine blood collected from 26 normal horses was processed by 4 methods: blood collection tubes centrifuged at 1200 and 2000 × g, 50-mL conical tube, and a commercial...
Platelet-rich plasma (PRP) is a popular treatment for equine tendon and ligament injuries; however, commercial PRP systems are expensive. Development of a safe, inexpensive alternative would make PRP therapy more widely available to horse owners. The purpose of this study was to evaluate the quality and bacteriologic safety of PRP produced by three...
Platelet rich plasma (PRP) is a common treatment for equine tendon and
ligament injuries but can be expensive. Safe, cost-effective PRP preparation
would make it more widely available. The purpose of this project was
to compare simplified methods of PRP preparation to a commercial system.
We hypothesized that one of these simple methods would conce...
Citations
... Because the observed bias tends to be proportional it becomes more important with sSDMA concentrations exceeding the RI to use the same analyzer during follow-up. Intermittent use of the POC and CL analyzer carries the inherent risk of misinterpreting analytical variability as clinically relevant changes.Because recalibration or assay method improvement is not possible for POC analyzers, it is often suggested to apply a correction factor to adjust the existing RI or create an assay-specific RI.10,41,39 Doing so compensates for constant systemic error41 and additionally raises awareness among clinicians not to use the assays interchangeably. However, it does not fully address the proportional bias observed in our data. ...
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... 19 The actual concentrations of growth factors released by the platelets may determine efficacy in enhancing tissue regeneration. [23][24][25][26][27] Higher platelet numbers in PRP correspond to higher levels of available growth factors. 3,24,26,27 Optimal concentrations of platelets and WBC are likely to be specific to different clinical applications and are the topics of ongoing research. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/675185430646785-1537988159618_Q64/Robin-Fontenot.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/811021002346497-1570373883935_Q64/Linda-Dahlgren.jpg)
... Te remaining 25% was pipetted to dissolve the pellet formed in the fnal portion of the tube. Tis last fraction was considered as PRP after the fnal platelet count above 300,000/μL, as described by [30][31][32]. Red blood cell and leukocyte counts were also performed using an impedance hemocytometer (Icounter Vet ® , DIAGNO, Brazil). ...
